Results 51 to 60 of about 263,469 (298)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The performance of the adaptive optimal estimator under the extended balanced loss function

open access: yes, 2017
The adaptive optimal estimator of Farebrother (1975) is discussed by many authors, but the goodness of fitted model criterion that is used to investigate the performance of estimators is quite often ignored.
Kaçıranlar S., Özbay N.
core   +1 more source

A ranking-based, balanced loss function unifying classification and localisation in object detection [PDF]

open access: yes, 2020
We propose average Localisation-Recall-Precision (aLRP), a unified, bounded, balanced and ranking-based loss function for both classification and localisation tasks in object detection.
Kalkan, Sinan   +3 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A generalization of the credibility theory obtained by using the weighted balanced loss function

open access: yes, 2008
n this paper an alternative to the usual credibility premium that arises for weighted balanced loss function is considered. This is a generalized loss function which includes as a particular case the weighted quadratic loss function traditionally used in
Gómez Déniz, Emilio
core   +1 more source

Deep Supervised Hashing for Fast Multi-Label Image

open access: yesMATEC Web of Conferences, 2018
In this paper, most of the existing Hashing methods is mapping the hand extracted features to binary code, and designing the loss function with the label of images.
Ying Qian, Qingqing Ye
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Remote Sensing Image Retrieval by Deep Attention Hashing With Distance-Adaptive Ranking

open access: yesIEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2023
With the joint advancement of numerous related fields of remote sensing, the amount of remote sensing data is growing exponentially. As an essential remote sensing Big Data management technique, content-based remote sensing image retrieval has attracted ...
Yichao Zhang   +2 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

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