Results 71 to 80 of about 263,469 (298)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

All admissible linear estimators of a regression coefficient under a balanced loss function

, 2011
Admissibility of linear estimators of a regression coefficient in linear models with and without the assumption that the underlying distribution is normal is discussed under a balanced loss function.
Peng, Ping, Guikai Hu, Hu, Guikai, Ping Peng   +3 more
core   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Score-balanced Loss for Multi-aspect Pronunciation Assessment

, 2023
With rapid technological growth, automatic pronunciation assessment has transitioned toward systems that evaluate pronunciation in various aspects, such as fluency and stress.
Kim, Yunsu, Lee, Gary Geunbae, Do, Heejin   +2 more
core   +1 more source

Hybrid Loss-Based Deep Learning Framework Using EfficientNet-B3 for Multi-Class Colorectal Cancer Detection

AI
Diagnosis of colorectal cancer (CRC) primarily relies on histopathological examination of hematoxylin and eosin-stained tissue sections; however, manual interpretation is time-consuming, subjective, and increasingly impractical given the rapid growth of ...
Anusha Nallamalla, Chandrakanta Mahanty
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Dynamically Weighted Balanced Loss: Class Imbalanced Learning and Confidence Calibration of Deep Neural Networks

, 2021
Imbalanced class distribution is an inherent problem in many real-world classification tasks where the minority class is the class of interest. Many conventional statistical and machine learning classification algorithms are subject to frequency bias ...
Fernando, K. Ruwani M., Tsokos, Chris P.
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Minimax estimator of regression coefficient in normal distribution under balanced loss function

, 2012
This article investigates linear minimax estimators of regression coefficient in a linear model with an assumption that the underlying distribution is a normal one with a nonnegative definite covariance matrix under a balanced loss function.
Peng, Ping, Guikai Hu, Qingguo Li, Hu, Guikai, Ping Peng, Li, Qingguo   +5 more
core   +1 more source

BWLM: A Balanced Weight Learning Mechanism for Long-Tailed Image Recognition

Applied Sciences
With the growth of data in the real world, datasets often encounter the problem of long-tailed distribution of class sample sizes. In long-tailed image recognition, existing solutions usually adopt a class rebalancing strategy, such as reweighting based ...
Baoyu Fan, Han Ma, Yue Liu, Xiaochen Yuan   +3 more
doaj   +1 more source