Results 81 to 90 of about 263,469 (298)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Incentives and Managerial Experience in Multi-task Teams: Evidence from within a Firm [PDF]

, 2008
This paper exploits a quasi-experimental setting to estimate the impact that a multi-dimensional group incentive scheme had on branch performance in a large distribution firm.
Griffith, Rachel, Neely, Andrew
core  

More Teeth and Posterior Balanced Occlusion Are a Key Determinant for Cognitive Function in the Elderly

, 2021
Age-related decline in cognitive function is a major challenge in geriatric healthcare. A possible explanation is that the tooth loss or low chewing ability is at cause of cognitive impairment or dementia.
Youn-Hee Choi, Atsuo Amano, Keunbada Son, Keun-Bae Song, Yong-Chul Bae, Taejun Park, Yun-Sook Jung   +6 more
core   +1 more source

SVD-CLAHE boosting and balanced loss function for Covid-19 detection from an imbalanced Chest X-Ray dataset. [PDF]

Comput Biol Med, 2022
Roy S, Tyagi M, Bansal V, Jain V.
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Optimization of PINN Loss Function and Solution of Partial Differential Equation Based on Dynamic Weighting With Subconstraints and Multiregion Adaptive Sampling

Journal of Applied Mathematics
Traditional numerical methods have limitations such as grid dependence and poor adaptability to high-dimensional problems when solving partial differential equations.
Xiaofei Yu, Jinyan Tian
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Minimax Estimation of Multivariate Normal Mean Under Balanced Loss Function

, 2007
This paper considers simultaneous estimation of multivariate normal mean vector using Zellner's(1994) balanced loss function when oe 2 is known and unknown.
Younshik Chung, Chansoo Kim
core