Results 51 to 60 of about 10,401 (258)
Cracking the Code: Genotype–Phenotype Correlation Models in Sarcoglycanopathies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Sarcoglycanopathies are among the most severe limb‐girdle muscular dystrophies (LGMD), though milder presentations have been described. These diseases are primarily caused by missense variants, but the limited predictability of their effect on protein maturation, complex formation, and transport has hindered reliable genotype ...
Leonela Luce +72 more
wiley +1 more source
A symmetry approach for balanced truncation of positive linear systems [PDF]
2012 IEEE 51st IEEE Conference on Decision and Control (CDC), 2012 We consider model order reduction of positive linear systems and show how a symmetry characterization can be used in order to preserve positivity in balanced truncation. The reduced model has the additional feature of being symmetric.
Christian Grussler, Tobias Damm
openaire +2 more sources
RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu +21 more
wiley +1 more source
A Residual Approach for Balanced Truncation Model Reduction (BTMR) of Compartmental Systems
Bulletin of Computational Applied Mathematics, 2014 This paper presents a residual approach of the square root balanced truncation algorithm for model order reduction of continuous, linear and time-invariante compartmental systems.
William La Cruz
doaj
Controller Reduction of Parameter Dependent Systems [PDF]
ITB Journal of Engineering Science, 2004 This paper proposes a controller reduction of linear parameter dependent systems. A measure of the degradation is derived for the parameter dependent closed-loop performance caused by applying the reduced-order parameter dependent controller.
Widowati +2 more
doaj
Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin +11 more
wiley +1 more source
A Forecast Test for Reducing Dynamical Dimensionality of Model Emulators
Journal of Advances in Modeling Earth SystemsThe climate system can be numerically represented by a set of physically based dynamical equations whose solution requires substantial computational resources.
Tongtong Xu +3 more
doaj +1 more source
Empirical Reduced-Order Modeling for Boundary Feedback Flow Control
Journal of Control Science and Engineering, 2008 This paper deals with the practical and theoretical implications of model reduction for aerodynamic flow-based control problems. Various aspects of model reduction are discussed that apply to partial differential equation- (PDE-) based models in general.
Seddik M. Djouadi +2 more
doaj +1 more source
Clinical Impact of NOTCH3 Variant Location After First Stroke in CADASIL
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Despite its monogenic origin, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy exhibits marked variability in clinical expression and severity. Variants in the NOTCH3 gene, within epidermal growth factor‐like repeat domains 1–6 or 7–34, are known to influence disease onset, but their impact ...
Léa Aguilhon +5 more
wiley +1 more source
Structure-Preserving Low-Rank Model Reduction for Second-Order Time-Delay Systems
MathematicsThis paper introduces two model order-reduction techniques for second-order time-delay systems. The first method involves converting the second-order system into a first-order form, along with a set of related structure-preserving algorithms.
Man Tang, Zhi-Hua Xiao, Umair Zulfiqar
doaj +1 more source