Results 51 to 60 of about 587,507 (249)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Realism vs. Neoliberalism and Constructivism: Main Points of Debate

open access: yesVestnik MGIMO-Universiteta, 2015
: Following the collapse of the bipolar world realist approaches were placed under close scrutiny by neoliberals and constructivists. The legacy of the realist school actually became an object of numerous attacks, which were undertaken to demonstrate its
Yury V. Borovsky, Pavel A. Gvozdev
doaj  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Security Dilemma of the American Ballistic Missile Defense

open access: yesCzech Journal of International Relations, 2013
The article deals with the former US President Bush’s plan for the so-called third pillar of the American missile defense system in Poland and the Czech Republic in the context of American-Iranian and American-Russian relations.
Lukáš Kantor
doaj  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Conceptual design and architecture of an informatics solution for smart trading on wholesale energy market in Romania [PDF]

open access: yesDatabase Systems Journal, 2017
This paper presents conceptual design and architecture of an informatics solution that aims to implement analytical models for optimization and forecasting the electricity demand and generation, simulation and what if analysis for efficient trading ...
Adela BÂRA   +3 more
doaj  

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

An Institutional Frame to Compare Alternative Market Designs in EU Electricity Balancing [PDF]

open access: yes, 2006
The so-called â electricity wholesale marketâ is, in fact, a sequence of several markets. The chain is closed with a provision for â balancing,â in which energy from all wholesale markets is balanced under the authority of the Transmission Grid ...
Marcelo Saguan   +3 more
core   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

A Simulated Annealing Method to Cover Dynamic Load Balancing in Grid Environment [PDF]

open access: yes, 2009
High-performance scheduling is critical to the achievement of application performance on the computational grid. New scheduling algorithms are in demand for addressing new concerns arising in the grid environment.
Herrero Martín, María del Pilar   +1 more
core   +1 more source

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