Results 221 to 230 of about 84,298 (262)

Adaptive-expert-weight-based load balance scheme for dynamic routing of MoE. [PDF]

Front Neurorobot
Wen J, Li X, Yao J, Kong X, Cheng P.
europepmc   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Cluster minimal sufficient balance (CMSB): an efficient covariate balancing randomization method for cluster randomized trials. [PDF]

BMC Med Res Methodol
Cai J, Suo S, Ndip V, Khairallah C, Zhang B, Zeng L, Yan H, Shao F, Chen T, Li C.   +9 more
europepmc   +1 more source

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe, Keizo Sugaya, Kentaro Hayashi, Keiko Hino, Yasuhiro Nakata, Kota Bokuda, Toshio Shimizu, Kazushi Takahashi   +7 more
wiley   +1 more source

PRAISE-H study exploring real-world challenges faced by reproductive-age patients with rheumatoid arthritis in Japan. [PDF]

Front Med (Lausanne)
Takai C, Fujioka I, Goto M.
europepmc   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Hybrid GA-PSO Optimization for Controller Placement in Large-Scale Smart City IoT Networks. [PDF]

Sensors (Basel)
Memon SA, Andriukaitis D, Navikas D, Markevičius V, Valinevičius A, Žilys M, Prauzek M, Konecny J, Li Z, Sledevič T, Frivaldsky M, Klimenta D.   +11 more
europepmc   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Adaptive balancing of effort, accuracy and response speed in anomia treatment for post-stroke aphasia in community-based settings in the USA: a within-subjects randomised controlled trial protocol. [PDF]

BMJ Open
van der Stelt CM, Cavanaugh R, Hula WD, Starns J, Kelly A, Goodman ML, Terhorst L, Hassany M, Brusilovsky P, Evans WS.   +9 more
europepmc   +1 more source

Evolutionary Balancing of Genetic Consequence and Innovation in Mammals Through Variable Number Tandem Repeats. [PDF]

Genome Biol Evol
Pajic P, Gokcumen O.
europepmc   +1 more source