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Diagnostic Criteria for Balkan Endemic Nephropathy: Proposal by an International Panel

open access: yesRenal Failure, 2007
Balkan endemic nephropathy (BEN) is a familial chronic tubulointerstitial disease with insidious onset and slow progression to terminal renal failure. Diagnostic criteria for BEN have been described more than 40 years ago.
Vladisav ŠTEFANOVIC   +2 more
exaly   +2 more sources
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Balkan endemic nephropathy

2003
Ljubica Djukanovic, Zoran Radovanovic
exaly   +2 more sources

Pathomorphology of Balkan endemic nephropathy

Food and Chemical Toxicology, 1992
Within the county of Slavonski Brod, Yugoslavia hyperendemic areas of Balkan endemic nephropathy (BEN) have been recognized for a long time. As the Department of Pathology and Forensic Medicine of the Medical Centre in Slavonski Brod is responsible for all diagnostic post-mortem examinations in the county, and at the same time is engaged in surgical ...
M, Vukelić, B, Sostarić, M, Belicza
openaire   +2 more sources

Epidemiology of Balkan endemic nephropathy

Food and Chemical Toxicology, 1992
The first outbreak of Balkan endemic nephropathy (BEN) was reported between 1955 and 1957, initially in Serbia and soon afterwards in Croatia and in Bosnia and Herzegovina. The disease appears to be of a focal nature. In Yugoslavia at least six foci are known, generally along major rivers of the Danubian river basin, in areas that have often been ...
S, Ceović, A, Hrabar, M, Sarić
openaire   +2 more sources

Genetic Predisposition to Balkan Endemic Nephropathy

Nephron, 2008
This study is the first cytogenetic investigation of healthy relatives of patients with Balkan endemic nephropathy (BEN) who were born in nonendemic areas. Characteristics of BEN No. 3 chromosomal anomalies (extremely high frequencies of 3q25 homologue discordance – 68.5 ± (SD) 5.03% vs. 6.65 ± 0.95% in controls, p < 0.001; chromosome breaks at 3q25
D, Toncheva, T, Dimitrov
openaire   +2 more sources

Clinical features of Balkan endemic nephropathy

Food and Chemical Toxicology, 1992
This paper describes the clinical symptoms and signs of Balkan endemic nephropathy (BEN). The initial asymptomatic period followed by weakness and lassitude during renal insufficiency is emphasized. Non-characteristic lumbar pain may be present and episodes of macrohaematuria may occur.
M, Radonić, Z, Radosević
openaire   +2 more sources

Groundwater chemistry and the Balkan endemic nephropathy

Environmental Geochemistry and Health, 1991
Until now failure has been a common feature of all attempts to elucidate the aetiology of Balkan endemic nephropathy (BEN), a peculiar kidney disease known to exist only in south-eastern Europe. However, whatever the cause, many epidemiological data point to water as a vehicle of the unknown agent(s).
Z, Radovanovic, W M, Edmunds
openaire   +2 more sources

Cytogenetic Studies in Balkan Endemic Nephropathy

Nephron, 2008
The G band characteristic of chromosomes in 15 patients with Balkan endemic nephropathy (BEN), 20 relatives with no features of the disease and 25 healthy controls were investigated by cytogenetic analysis of lymphocyte cultures from peripheral blood. A specific chromosome marker in BEN was established in one No. 3 chromosome homologue characterized by
D, Toncheva, T, Dimitrov, M, Tzoneva
openaire   +2 more sources

Metabolic activation of carcinogenic aristolochic acid, a risk factor for Balkan endemic nephropathy [PDF]

open access: yesMutation Research - Reviews in Mutation Research, 2008
Aristolochic acid (AA), a naturally occurring nephrotoxin and carcinogen, is associated with tumor development in patients suffering from Chinese herbs nephropathy (now termed aristolochic acid nephropathy, AAN) and may also be a cause for the ...
Marie Stiborova   +2 more
exaly   +2 more sources

Survival of Balkan Endemic Nephropathy Patients

Nephron, 2000
The retrospective cohort study comprised 97 Balkan endemic nephropathy (BEN) and BEN-suspected patients discovered in 1971 in the field examination in the village of Šopić, one of the regions most frequently affected by the disease. Our aim was to determine the outcome of the disease in patients and to compare the survival of BEN-suspected and BEN ...
D, Bukvić   +3 more
openaire   +2 more sources

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