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Diagnostic Criteria for Balkan Endemic Nephropathy: Proposal by an International Panel
Balkan endemic nephropathy (BEN) is a familial chronic tubulointerstitial disease with insidious onset and slow progression to terminal renal failure. Diagnostic criteria for BEN have been described more than 40 years ago.
Vladisav ŠTEFANOVIC +2 more
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Pathomorphology of Balkan endemic nephropathy
Food and Chemical Toxicology, 1992Within the county of Slavonski Brod, Yugoslavia hyperendemic areas of Balkan endemic nephropathy (BEN) have been recognized for a long time. As the Department of Pathology and Forensic Medicine of the Medical Centre in Slavonski Brod is responsible for all diagnostic post-mortem examinations in the county, and at the same time is engaged in surgical ...
M, Vukelić, B, Sostarić, M, Belicza
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Epidemiology of Balkan endemic nephropathy
Food and Chemical Toxicology, 1992The first outbreak of Balkan endemic nephropathy (BEN) was reported between 1955 and 1957, initially in Serbia and soon afterwards in Croatia and in Bosnia and Herzegovina. The disease appears to be of a focal nature. In Yugoslavia at least six foci are known, generally along major rivers of the Danubian river basin, in areas that have often been ...
S, Ceović, A, Hrabar, M, Sarić
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Genetic Predisposition to Balkan Endemic Nephropathy
Nephron, 2008This study is the first cytogenetic investigation of healthy relatives of patients with Balkan endemic nephropathy (BEN) who were born in nonendemic areas. Characteristics of BEN No. 3 chromosomal anomalies (extremely high frequencies of 3q25 homologue discordance – 68.5 ± (SD) 5.03% vs. 6.65 ± 0.95% in controls, p < 0.001; chromosome breaks at 3q25
D, Toncheva, T, Dimitrov
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Clinical features of Balkan endemic nephropathy
Food and Chemical Toxicology, 1992This paper describes the clinical symptoms and signs of Balkan endemic nephropathy (BEN). The initial asymptomatic period followed by weakness and lassitude during renal insufficiency is emphasized. Non-characteristic lumbar pain may be present and episodes of macrohaematuria may occur.
M, Radonić, Z, Radosević
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Groundwater chemistry and the Balkan endemic nephropathy
Environmental Geochemistry and Health, 1991Until now failure has been a common feature of all attempts to elucidate the aetiology of Balkan endemic nephropathy (BEN), a peculiar kidney disease known to exist only in south-eastern Europe. However, whatever the cause, many epidemiological data point to water as a vehicle of the unknown agent(s).
Z, Radovanovic, W M, Edmunds
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Cytogenetic Studies in Balkan Endemic Nephropathy
Nephron, 2008The G band characteristic of chromosomes in 15 patients with Balkan endemic nephropathy (BEN), 20 relatives with no features of the disease and 25 healthy controls were investigated by cytogenetic analysis of lymphocyte cultures from peripheral blood. A specific chromosome marker in BEN was established in one No. 3 chromosome homologue characterized by
D, Toncheva, T, Dimitrov, M, Tzoneva
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Metabolic activation of carcinogenic aristolochic acid, a risk factor for Balkan endemic nephropathy [PDF]
Aristolochic acid (AA), a naturally occurring nephrotoxin and carcinogen, is associated with tumor development in patients suffering from Chinese herbs nephropathy (now termed aristolochic acid nephropathy, AAN) and may also be a cause for the ...
Marie Stiborova +2 more
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Survival of Balkan Endemic Nephropathy Patients
Nephron, 2000The retrospective cohort study comprised 97 Balkan endemic nephropathy (BEN) and BEN-suspected patients discovered in 1971 in the field examination in the village of Šopić, one of the regions most frequently affected by the disease. Our aim was to determine the outcome of the disease in patients and to compare the survival of BEN-suspected and BEN ...
D, Bukvić +3 more
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