Results 1 to 10 of about 188,475 (162)

Unusual Urothelial Tumors and Refractory Uremia Due to Balkan Endemic Nephropathy: A Case Report [PDF]

Journal of Investigative Medicine High Impact Case Reports
Balkan endemic nephropathy (BEN) is a rare progressive chronic renal disease found in residents living along the Balkan peninsula. We present a 92-year-old female who complained initially of cardio-respiratory symptoms and was found to have an acute ...
Gevorg Arabyan BS, Raphi Hambartzhumian MD, Anthony Lim MD, Marrey Quizon MD, Julia Oberndorf MD, Michael A. Sanford MD   +5 more
doaj   +3 more sources

SGLT2 inhibitor dapagliflozin protects the kidney in a murine model of Balkan nephropathy.

Am J Physiol Renal Physiol, 2023
Proximal tubular uptake of aristolochic acid (AA) forms aristolactam (AL)-DNA adducts, which cause a p53/p21-mediated DNA damage response and acute tubular injury.
Oe Y, Kim YC, Sidorenko VS, Zhang H, Kanoo S, Lopez N, Goodluck HA, Crespo-Masip M, Vallon V.   +8 more
europepmc   +2 more sources

Differences in Risk Factors and Prevalence of Vascular Calcification between Pre-Dialysis and Hemodialysis Balkan Nephropathy Patients. [PDF]

Medicina (Kaunas), 2018
Aims: The aim of this study was to compare the risk factors and prevalence of vascular calcification (VC) in pre-dialysis and hemodialysis (HD) patients with Balkan endemic nephropathy (BEN) or other kidney diseases (non-BEN).
Petković N, Ristić S, Marinković J, Marić R, Kovačević M, Djukanović L.   +5 more
europepmc   +2 more sources

Long-Term Outcome of Kidney Transplant Patients from Rural Farming Areas with Balkan Nephropathy-A Single-Centre Report. [PDF]

J Clin Med
Background: Balkan nephropathy (BEN) is an environmental form of aristolochic acid nephropathy (AAN) strongly associated with upper urinary tract urothelial carcinoma (UTUC). Clinical diagnosis remains challenging, and misclassification is frequent.
Rukavina L, Živčić-Ćosić S, Markić D, Štemberger C, Ljubić J, Rukavina T, Španjol J, Brzić I, Samardžić J, Domislović M, Bašić-Jukić N, Jelaković B.   +11 more
europepmc   +2 more sources

Cancer Incidence and Outcomes After Kidney Transplantation in Balkan Nephropathy Patients. [PDF]

J Clin Med
Background: Balkan nephropathy (BEN), caused by chronic dietary exposure to aristolochic acid (AA), is a tubulointerstitial kidney disease strongly associated with upper-tract urothelial carcinoma (UTUC).
Prtorić M, Atić A, Jelaković B, Kaštelan Ž, Bašić-Jukić N.   +4 more
europepmc   +2 more sources

Histopathological review of renal pelvic tumours of Balkan nephropathy cases from Southern Serbia

Annals of Urologic Oncology, 2020
Background Urothelial tumour frequently associates with atrophied kidney pelvis in Balkan endemic nephropathy but histopathology illustration lacks both definition and immune profile for differential diagnosis from renal cell carcinoma.
Diana Herman, Goran Stanojević, Nikola Pavlović, Peter Mantle   +3 more
doaj   +2 more sources

Western diet exacerbates a murine model of Balkan nephropathy.

Am J Physiol Renal Physiol
Aristolochic acid (AA) ingestion causes Balkan nephropathy, characterized by tubular injury and progression to chronic kidney disease (CKD). AA is taken up by proximal tubule cells via organic anion transport and induces p21-mediated DNA damage response,
Oe Y, Kim YC, Kanoo S, Goodluck HA, Lopez N, Diedrich J, Pinto AM, Evensen KG, Currais AJM, Maher P, Vallon V.   +10 more
europepmc   +2 more sources

Aristolochic acid and the etiology of endemic (Balkan) nephropathy. [PDF]

Proc Natl Acad Sci U S A, 2007
Endemic (Balkan) nephropathy (EN), a devastating renal disease affecting men and women living in rural areas of Bosnia, Bulgaria, Croatia, Romania, and Serbia, is characterized by its insidious onset, invariable progression to chronic renal failure and a
Grollman AP, Shibutani S, Moriya M, Miller F, Wu L, Moll U, Suzuki N, Fernandes A, Rosenquist T, Medverec Z, Jakovina K, Brdar B, Slade N, Turesky RJ, Goodenough AK, Rieger R, Vukelić M, Jelaković B.   +17 more
europepmc   +2 more sources

Molecular Characterization of Microrna Interference and Aristolochic Acid Intoxication Found in Upper Tract Urothelial Carcinoma in Patients with Balkan Endemic Nephropathy: A Systematic Review of the Current Literature [PDF]

Balkan Journal of Medical Genetics, 2022
The term “aristolochic acid nephropathy” (AAN) is used to include any form of toxic interstitial nephropathy that is caused either by ingestion of plants containing aristolochic acids (AA) or by the environmental contaminants in food such as in Balkan ...
Bašić D, Ignjatović I, Janković Veličković Lj, Veljković A   +3 more
doaj   +2 more sources

Prognostic value of p53, c-ErbB2 and tunel data in upper urothelial carcinoma associated with Balkan nephropathy [PDF]

Archives of Biological Sciences, 2014
A characteristic tumor suppressor protein 53 (p53) mutational profile of genotoxic action of aristolochic acid was identified in the upper urothelial carcinoma (UUTT) associated with Balkan nephropathy (BEN).
Savin Marina, Džamić Z., Baralić M., Radojević-Škodrić Sanja, Marinković Jelena, Bumbaširević V.   +5 more
doaj   +2 more sources