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Balkan (or endemic) nephropathy is a chronic tubulointerstitial disease of unknown, presumably exotoxic etiology. It has been shown to exist only in some parts of the southeastern Europe. While there have been many meetings and papers [1, 2] concerning both cause and treatment of Balkan nephropathy, sociopolitical turmoil, including wars, and ...
DjukanoviĆ L, RadovanoviĆ Z.
europepmc +5 more sources
Balkan Endemic Nephropathy and the Causative Role of Aristolochic Acid [PDF]
Summary: Balkan endemic nephropathy is a chronic tubulointerstitial disease with insidious onset, slowly progressing to end-stage renal disease and frequently associated with urothelial carcinoma of the upper urinary tract (UTUC).
Bojan Jelaković +2 more
exaly +2 more sources
Balkan endemic nephropathy: Role of ochratoxins A through biomarkers [PDF]
Several studies implicated mycotoxins, in endemic kidney disease geographically limited to Balkan region (Balkan endemic nephropathy (BEN)). In Bulgaria, much higher prevalence of ochratoxin A (OTA), exceeding 2 lg/L, was observed in the blood of ...
Annie Pfohl-Leszkowicz
exaly +2 more sources
p53 mutations as fingerprints for aristolochic acid: an environmental carcinogen in endemic (Balkan) nephropathy. [PDF]
The activation of protooncogenes and inactivation of tumor suppressor genes are considered to be the main molecular events in the multistep process of carcinogenesis.
Slade N +4 more
europepmc +2 more sources
Consensus statement on screening, diagnosis, classification and treatment of endemic (Balkan) nephropathy. [PDF]
Currently used diagnostic criteria in different endemic (Balkan) nephropathy (EN) centers involve different combinations of parameters, various cut-off values and many of them are not in agreement with proposed international guidelines.
Jelaković B +35 more
europepmc +2 more sources
Metabolic activation of carcinogenic aristolochic acid, a risk factor for Balkan endemic nephropathy [PDF]
Aristolochic acid (AA), a naturally occurring nephrotoxin and carcinogen, is associated with tumor development in patients suffering from Chinese herbs nephropathy (now termed aristolochic acid nephropathy, AAN) and may also be a cause for the ...
Marie Stiborova +2 more
exaly +2 more sources
Urinary neopterin concentrations in patients with Balkan endemic nephropathy (BEN)
Urinary neopterin concentrations in patients with Balkan endemic nephropathy (BEN).BackgroundBalkan endemic nephropathy (BEN) is of great clinical importance in restricted areas of Bulgaria, Serbia, Croatia, Bosnia, Herzegovina, and Romania, since the ...
Draga Toncheva +2 more
exaly +2 more sources
Chinese herbs nephropathy: a clue to Balkan endemic nephropathy?
Rapidly progressive interstitial renal fibrosis has recently been reported in young women who have been on a slimming regimen including Chinese herbs.
Jadoul, Michel +5 more
core +3 more sources
Balkan endemic nephropathy (BEN) is a chronic, slowly progressive tubulointerstitial nephritis, with familial clustering, occurring in several endemic rural regions in countries of the Balkan Peninsula.
Adalbert Schiller, Milan Radović
core +2 more sources
Aristolochic acid and the etiology of endemic (Balkan) nephropathy. [PDF]
Endemic (Balkan) nephropathy (EN), a devastating renal disease affecting men and women living in rural areas of Bosnia, Bulgaria, Croatia, Romania, and Serbia, is characterized by its insidious onset, invariable progression to chronic renal failure and a
Grollman AP +17 more
europepmc +2 more sources

