Results 11 to 20 of about 318,519 (201)

p53 mutations as fingerprints for aristolochic acid: an environmental carcinogen in endemic (Balkan) nephropathy. [PDF]

Mutat Res, 2009
The activation of protooncogenes and inactivation of tumor suppressor genes are considered to be the main molecular events in the multistep process of carcinogenesis.
Slade N, Moll UM, Brdar B, Zorić A, Jelaković B.   +4 more
europepmc   +4 more sources

Is Aristolochic Acid Really the Cause of the Balkan Endemic Nephropathy? [PDF]

Journal of Controversies in Biomedical Research, 2016
In recent years, aristolochic acid has been promoted vigorously as the causal agent of the Balkan endemic nephropathy because of similarities to some other nephropathies, association with DNA adducts and a perception of human exposure via bread. Critical
Peter George Mantle, Diana Herman, Calin Tatu   +2 more
doaj   +2 more sources

Beyond Tradition: An Integrated Toxicological, Ecological, and Public Health Perspective on Aristolochic Acids. [PDF]

J Appl Toxicol
ABSTRACT Aristolochia species have long been used in traditional medicine for their presumed anti‐inflammatory, analgesic and antimicrobial properties. However, extensive toxicological and epidemiological evidence now demonstrates that these plants contain aristolochic acids (AAs) I and II, highly potent nephrotoxic, genotoxic, and carcinogenic ...
de Souza VV, De Andrade LR, da Silva Souza T.   +2 more
europepmc   +2 more sources

Balkan nephropathy: evolution of our knowledge. [PDF]

Am J Kidney Dis, 2008
Balkan endemic nephropathy (BEN), originally described in the late 1950s as a chronic tubulointerstitial kidney disease, is identified by its unique epidemiological features.
Bamias G, Boletis J.
europepmc   +2 more sources

Early Detection of Balkan Endemic Nephropathy in Bosanska Posavina [PDF]

Biomolecules & Biomedicine, 2010
Balkan endemic nephropathy (BEN) is a chronic tubulointersticial nephropathy that is diagnosed in a few agrarian regions of Balkan. Even tough numerous dilemmas and conflicting opinions regarding BEN etiology are encountered in literature, prevailing ...
Enisa Mešić
doaj   +2 more sources

Longer Telomere Length in Patients with Balkan Endemic Nephropathy Undergoing Chronic Hemodialysis Is Associated with Lower Cardiovascular Mortality. [PDF]

Kidney360
BACKGROUND Balkan endemic nephropathy (BEN) is characterized with later onset and milder forms of hypertension, and with lower pulse wave velocity (PWV) than other end-stage kidney disease (ESKD).
Premužić V, Toupance S, Toupance S, Hollander A, Stipančić Ž, Bukal N, Jelaković A, Brzić I, Čulig B, Slade N, Benetos A, Jelaković B.   +11 more
europepmc   +2 more sources

Consensus statement on screening, diagnosis, classification and treatment of endemic (Balkan) nephropathy. [PDF]

Nephrol Dial Transplant, 2014
Jelaković B, Nikolić J, Radovanović Z, Nortier J, Cosyns JP, Grollman AP, Bašić-Jukić N, Belicza M, Bukvić D, Čavaljuga S, Čvorišćec D, Cvitković A, Dika Ž, Dimitrov P, Đukanović L, Edwards K, Ferluga D, Fuštar-Preradović L, Gluhovschi G, Imamović G, Jakovina T, Kes P, Leko N, Medverec Z, Mesić E, Miletić-Medved M, Miller F, Pavlović N, Pasini J, Pleština S, Polenaković M, Stefanović V, Tomić K, Trnačević S, Vuković Lela I, Štern-Padovan R.   +35 more
europepmc   +2 more sources

Inaccuracy of Ureteroscopic Biopsy in Upper Tract Urothelial Carcinoma Can Lead to False Therapeutic Decisions: A Case Report. [PDF]

Clin Case Rep
ABSTRACT Do not rely solely on negative endoscopic biopsies when diagnosing upper tract urothelial carcinoma (UTUC). Repeat ureteroscopy with biopsy if initial results are negative to reduce false negatives. Frozen section analysis (FSA) can provide rapid intraoperative confirmation and guide treatment decisions.
Hidayat-Allah A, Friedersdorff F.
europepmc   +2 more sources

Expression of Basal Compartment and Superficial Markers in Upper Tract Urothelial Carcinoma Associated with Balkan Endemic Nephropathy, a Worldwide Disease

Biomedicines
The aim of this study was to determine the association of basal compartment and superficial markers, comprising CK5/6, CD44, CK20, and the pathological characteristics of upper tract urothelial carcinoma (UTUC) associated with Balkan endemic nephropathy (
Ljubinka Jankovic Velickovic, Ana Ristic Petrovic, Zana Dolicanin, Slavica Stojnev, Filip Velickovic, Dragoslav Basic   +5 more
doaj   +2 more sources

Acute Kidney Injury Following the Ingestion of a Medicinal Plants' Mixture: A Case Report. [PDF]

Case Rep Nephrol
Acute renal failure secondary to medicinal plants is common in countries where the use of traditional phytotherapy is preponderant. Although the nephrotoxic potentials of some herbal preparations have been well characterized, the use of many medicinal plants is still considered largely safe, often relying on weak evidence. Here, we report the case of a
Selles A, Afir Y, Rahou Y, Debchi L, Rafa-Debbah H, Bahriz MR, Benziane A.   +6 more
europepmc   +2 more sources