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Ochratoxin A: The Continuing Enigma [PDF]

Critical Reviews in Toxicology, 2005
The mycotoxin ochratoxin A (OTA) has been linked to the genesis of several disease states in both animals and humans. It has been described as nephrotoxic, carcinogenic, teratogenic, immunotoxic, and hepatotoxic in laboratory and domestic animals, as well as being thought to be the probable causal agent in the development of nephropathies (Balkan ...
Daniel Dietrich
exaly   +4 more sources

Comprehensive IAC Cross-Reactivity Validation and Stabilized Method Development for Ochratoxin A, B, and C in Complex Coffee and Spice Matrices [PDF]

Foods
Ochratoxins (OTs) pose a major food safety threat, yet analytical methodologies and regulations focus almost exclusively on ochratoxin A (OTA), overlooking the toxic analogues OTB and OTC, especially in complex coffee and spice matrices.
Jiaojiao Xu, Zengxuan Cai, Mengli Wang, Xiaomin Xu, Haitao Shen   +4 more
doaj   +2 more sources

Occurrence of the Ochratoxin A Degradation Product 2′R-Ochratoxin A in Coffee and Other Food: An Update

Toxins, 2019
Food raw materials can contain the mycotoxin ochratoxin A (OTA). Thermal processing of these materials may result in decreased OTA levels but also in the formation of the thermal isomerization product 2′R-ochratoxin A (2′R-OTA).
Benedikt Cramer, Olga R Torres, Hans-Ulrich Humpf   +2 more
exaly   +3 more sources

Teratogenicity of Ochratoxin A and the Degradation Product, Ochratoxin α, in the Zebrafish (Danio rerio) Embryo Model of Vertebrate Development

Toxins, 2016
Ochratoxins, and particularly ochratoxin A (OTA), are toxic fungal-derived contaminants of food and other agricultural products. Growing evidence supports the degradation of OTA by chemical, enzymatic and/or microbial means as a potential approach to ...
Keenan Mintz, Aaron Z Welch, Christopher Lawrence De Jesus   +2 more
exaly   +3 more sources

Biocatalytic Detoxification of Ochratoxins A/B by a Fungal Dye-Decolorizing Peroxidase: Mechanistic Insights and Toxicity Assessment [PDF]

Toxins
Mycotoxin contamination in agricultural products poses severe global health risks, with ochratoxins (particularly OTA and OTB) exhibiting marked nephrotoxicity and classified as Group 2B carcinogens by IARC.
Wenjing Xia, Nianqing Zhu, Jie Mei, Yueqin Peng, Fanglin Song, Shuai Ding, Fei Li, Xue Zhou   +7 more
doaj   +2 more sources

Toxico-pathological effects of ochratoxin A and its diastereoisomer under in ovo conditions and in vitro evaluation of the toxicity of these toxins against the embryo Gallus gallus fibroblast cell line

Poultry Science, 2023
: Herein, we conducted a comparative study on the embryotoxicity of ochratoxin A (OTA) and its diastereomer 2’R-ochratoxin A (2’R-OTA) under in ovo conditions, as well as assess the in vitro embryotoxicity of these substances together with ochratoxin B ...
Marcin Bryła, Krzysztof Damaziak, Magdalena Twarużek, Agnieszka Waśkiewicz, Łukasz Stępień, Marek Roszko, Adam Pierzgalski, Ewelina Soszczyńska, Monika Łukasiewicz-Mierzejewska, Marta Chmiel, Wojciech Wójcik   +10 more
doaj   +1 more source

Conversion of ochratoxin C into ochratoxin A in vivo [PDF]

Applied and Environmental Microbiology, 1984
The conversion of ochratoxin C to ochratoxin A was studied in rats after oral and intravenous administration. The concentration of ochratoxin A in the blood as a function of time was the same after oral administration of equivalent amounts of either ochratoxin C or ochratoxin A.
R, Fuchs, K, Hult, M, Peraica, B, Radić, R, Plestina   +4 more
openaire   +2 more sources

Ochratoxin A dietary exposure assessment in five food categories from Zhejiang Province

Zhongguo shipin weisheng zazhi, 2022
ObjectiveTo evaluate the food exposure risk of ochratoxin A （OTA） in Zhejiang Province， China.MethodsA representative of 518 samples （five food categories including 24 kinds of food stuffs） were examined from 2018 to 2019 in order to evaluate the ...
ZHAO Bi, WU Pinggu, ZHANG Ronghua, ZHAO Dong, ZHANG Hexiang, WU Xiaoli, CAI Zengxuan, CHEN Jiang, PAN Xiaodong, WANG Jikai, XU Jiaojiao, QI Xiaojuan, ZHOU Biao   +12 more
doaj   +1 more source

Biosynthesis of Ochratoxin A [PDF]

Applied Microbiology, 1969
Biosynthesis of ochratoxin A by Aspergillus ochraceus Wilh. was investigated by radiolabeling experiments in which phenylalanine- 1 - 14 C and sodium acetate- 2
J W, Searcy, N D, Davis, U L, Diener
openaire   +2 more sources

STUDY OF CONTAMINATION LEVEL OF OCHRATOXIN (A) IN IMPORED GRAINS WHEAT AND ITS PRODUCTS AT SOME LIBYAN FACTORIES [PDF]

Arab Universities Journal of Agricultural Sciences, 2016
This study was conducted to determine the present of Ochratoxin (A) (OTA) to the number of 50 samples of wheat grain from varieties of soft wheat (Tricticm astivum) and hard (T.
Altaher Alzwei, Najah Elfeturi
doaj   +1 more source