Peptide Marriages: Modular Assembly of Multi‐Agonist Therapeutics
Chemistry – A European Journal, EarlyView.A modular polyethylene glycol (PEG) scaffold enables rapid assembly of dual peptide agonists using strain‐promoted azide–alkyne cycloaddition (SPAAC) and copper‐catalysed azide–alkyne cycloaddition (CuAAC). Glucagon‐like peptide‐1 (GLP‐1) and amylin agonists were combined with controlled valency, yielding low‐picomolar activity and receptor‐selective ...
Kristina A. Kostadinova +11 more
wiley +1 more source
Evaluation of occlusion and disocclusion time in immediately loaded implant overdentures retained by two splinted versus non-splinted interforaminal implants: A randomized clinical trial. [PDF]
BMC Oral HealthRefai OM +2 more
europepmc +1 more source
Cross‐Dehydrogenative Coupling Reactions With Redox‐Active Guanidine Reagents
Chemistry – A European Journal, EarlyView.ABSTRACT Cross‐dehydrogenative coupling (CDC) reactions are attractive and environmentally friendly ways to form new C‐C and other element‐element bonds. Here, we report the first CDC reactions triggered by a redox‐active guanidine reagent. N‐phenyltetrahydroisoquinoline and derivatives with electron‐donating and withdrawing substituents at the N ...
Petra Walter +2 more
wiley +1 more source
Safety and benefits of adult-worn slings and baby carriers: a narrative systematic review to inform guidance for parents. [PDF]
BMJ Paediatr OpenLovell-Kennedy SR +3 more
europepmc +1 more source
Chemistry – A European Journal, EarlyView.Seven novel supramolecular photosensitizers based on benzo[c][1,2,5]thiadiazole (BTZ) tethered to calix[4]arene (C[4]) scaffolds are reported with facile, scalable, and selective syntheses. Their abilities to produce singlet oxygen have been tested through the photo‐oxidation of α‐terpinene.
Leonardo Amicosante +6 more
wiley +1 more source
Marginal bone loss in single implant-retained mandibular overdentures using two different healing protocols and two different types of attachments: A 2-year follow-up of a randomized controlled trial. [PDF]
Clin Oral InvestigAal MA +6 more
europepmc +1 more source
Cytoskeleton, EarlyView.ABSTRACT Cells sense the stiffness of their extracellular matrix (ECM) and adapt their behavior accordingly. We investigated how ECM stiffness affects the spatial organization of talin1, a key mechanosensitive focal adhesion protein. Using polyacrylamide (PA) hydrogels with tunable stiffnesses (0.2–188 kPa), we analyzed cell morphology, migration ...
Joanna Hajduk +5 more
wiley +1 more source
In vitro study of retention forces in traditional and PEEK milled ball attachments with two retentive caps. [PDF]
Sci RepLala S, Almustafa A, Alzoubi H.
europepmc +1 more source
Assembly and Maintenance of Myofibrils in the Heart
Cytoskeleton, EarlyView.ABSTRACT The assembly of actin and myosin to the paracrystalline arrangement of myofibrils in striated muscle, that is, heart and skeletal, has puzzled many a cell biologist. Different models, based on cultured cardiomyocytes, were proposed for the last 30 years to explain the sequence of events.
Elisabeth Ehler
wiley +1 more source
Metastable Protein-Protein Interactions as a Design Principle for PROTACs: Insights from the RIPK1-VHL System. [PDF]
JACS AuWu Y +4 more
europepmc +1 more source