Results 91 to 100 of about 130,114 (271)

Kronos: a workflow assembler for genome analytics and informatics. [PDF]

, 2017
BackgroundThe field of next-generation sequencing informatics has matured to a point where algorithmic advances in sequence alignment and individual feature detection methods have stabilized.
Aniba, Radhouane, Bashashati, Ali, Boutros, Paul C, Grande, Bruno M, Grewal, Diljot, Grewal, Jasleen, Morin, Ryan D, Rosner, Jamie, Shah, Sohrab P, Taghiyar, M Jafar   +9 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Enhancing communication and reducing anxiety: The role of problem-based learning in EFL learners’ psychological development

Ampersand
Problem-based Learning, an instructional approach focused on solving real-world problems, fosters self-guided learning under a facilitator's direction.
Saieed Moslemi Nezhad Arani
doaj   +1 more source

The WD40 Protein BamB Mediates Coupling of BAM Complexes into Assembly Precincts in the Bacterial Outer Membrane

Cell Reports, 2018
The β-barrel assembly machinery (BAM) complex is essential for localization of surface proteins on bacterial cells, but the mechanism by which it functions is unclear.
Sachith D. Gunasinghe, Takuya Shiota, Christopher J. Stubenrauch, Keith E. Schulze, Chaille T. Webb, Alex J. Fulcher, Rhys A. Dunstan, Iain D. Hay, Thomas Naderer, Donna R. Whelan, Toby D.M. Bell, Kirstin D. Elgass, Richard A. Strugnell, Trevor Lithgow   +13 more
doaj   +1 more source

Evolution of mobility governance in Flanders: opening up for bottom-up initiatives or suffering from lock-in? [PDF]

, 2015
Mobility policy in Flanders lacks a clear discourse on implementing the policy objectives for 2020 and beyond. Though mobility planning can show success stories, mobility problems seem to aggravate.
Boelens, Luuk, Lauwers, Dirk, Van Brussel, Suzanne   +2 more
core   +1 more source

Dimension Dependence of Clustering Dynamics in Models of Ballistic Aggregation and Freely Cooling Granular Gas

, 2017
Via event-driven molecular dynamics simulations we study kinetics of clustering in assemblies of inelastic particles in various space dimensions. We consider two models, viz., the ballistic aggregation model (BAM) and the freely cooling granular gas ...
Das, Subir K., Paul, Subhajit
core   +1 more source

Governance of Offshore IT Outsourcing at Shell Global Functions IT-BAM Development and Application of a Governance Framework to Improve Outsourcing Relationships [PDF]

, 2010
The lack of effective IT governance is widely recognized as a key inhibitor to successful global IT outsourcing relationships. In this study we present the development and application of a governance framework to improve outsourcing relationships.
A. Gopal, A. Schwartz, A.R. Hevner, C. Brown, D.-H. Yang, E. Beulen, J. Bon van, J. Luftman, L. Looff de, M.C. Lacity, P. Weill, P. Weill, R. Aron, R. Mirani, S. Cullen, T. Kern, T.R. Holcomb, V. Sambamurthy, W.R. King   +18 more
core   +2 more sources

Bam-dependent deubiquitinase complex can disrupt germ-line stem cell maintenance by targeting cyclin A [PDF]

Proceedings of the National Academy of Sciences, 2017
Significance Previous studies have demonstrated that Bam protein plays a critical role promoting early germ-line cell differentiation in the Drosophila ovary. Although its regulation and genetic functions have been extensively investigated over the last 20 years, the biochemical nature of Bam has still ...
Ji, Shanming, Li, Chaoyi, Hu, Lin, Liu, Kehui, Mei, Jie, Luo, Yuewan, Tao, Yi, Xia, Zongping, Sun, Qinmiao, Chen, Dahua   +9 more
openaire   +3 more sources

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source