Results 71 to 80 of about 130,114 (271)

Architecture and conformational dynamics of the BAM-SurA holo insertase complex

Science Advances
The proper folding of outer membrane proteins in Gram-negative bacteria relies on their delivery to the β-barrel assembly machinery (BAM) complex. The mechanism by which survival protein A (SurA), the major periplasmic chaperone, facilitates this process is not well understood.
Philippe A. Lehner, Morris Degen, Roman P. Jakob, Seyed Majed Modaresi, Morgane Callon, Björn M. Burmann, Timm Maier, Sebastian Hiller   +7 more
openaire   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Inverse topology in BL-algebras

پژوهش‌های ریاضی, 2020
In this paper, we introduce Inverse topology in a BL-algebra A and prove the set of all minimal prime filters of A, namely Min(A) with the Inverse topology is a compact space, Hausdorff, T0  and T1-Space.
Fereshteh Forouzesh, Farhad Sajadian, Mahta bedrood   +2 more
doaj  

The model of creating an entrepreneurial attitude of tourism students (case study: tourism students of universities in Yazd province) [PDF]

Muṭāli̒āt-i Mudīriyyat-i Gardishgarī
The purpose of this research is to design a model for creating entrepreneurial attitudes among tourism students at universities in Yazd . The statistical population of this research includes two groups: tourism experts and tourism students from ...
Ali Saffari Darberazi, reza derakhshan, Morteza Bazrafshan, Ahmad Hajimoradi,   +3 more
doaj   +1 more source

Gaia on-board metrology: basic angle and best focus [PDF]

, 2014
The Gaia payload ensures maximum passive stability using a single material, SiC, for most of its elements. Dedicated metrology instruments are, however, required to carry out two functions: monitoring the basic angle and refocusing the telescope.
Biermann, M., Brown, A. G. A., Busonero, D., Carminati, L., Carrasco, J. M., Chassat, F., Dool, T. C. van den, Erdmann, M., Gielesen, W. L. M., Jordi, C., Katz, D., Kohley, R., Lindegren, L., Loeffler, W., Marchal, O., Mora, A., Panuzzo, P., Sahlmann, J., Seabroke, G., Serpell, E., Serraller, I., van Leeuwen, F., van Reeven, W., Vosteen, L. L. A.   +23 more
core   +2 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

The effect of bambermycin, carbadox, chlortetracycline and olaquindox on antibiotic resistance in intestinal coliforms: a new animal model [PDF]

, 1984
Groups of germ-free mice kept in isolators and associated with faecal microflora from piglets were continuously given either water or a solution of one of the following: chlortetracycline (20 micrograms/ml), carbadox (50 micrograms/ml), olaquindox (50 ...
Corpet, Denis E.
core   +1 more source

The Reconstituted Escherichia coli Bam Complex Catalyzes Multiple Rounds of β-Barrel Assembly [PDF]

Biochemistry, 2011
β-Barrel proteins are folded and inserted into the outer membranes of Escherichia coli by the Bam complex. The Bam complex has been purified and functionally reconstituted in vitro. We report conditions for reconstitution that increase the folding yield 10-fold and allow us to monitor the time course of folding directly.
Christine L, Hagan, Daniel, Kahne
openaire   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

The Role of Extracellular Loops in the Folding of Outer Membrane Protein X (OmpX) of Escherichia coli

Frontiers in Molecular Biosciences, 2022
The outer membrane of Gram-negative bacteria acts as an additional diffusion barrier for solutes and nutrients. It is perforated by outer membrane proteins (OMPs) that function most often as diffusion pores, but sometimes also as parts of larger cellular
Simen Hermansen, David Ryoo, Marcella Orwick-Rydmark, Athanasios Saragliadis, James C. Gumbart, Dirk Linke   +5 more
doaj   +1 more source