Results 61 to 70 of about 5,482,674 (247)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Inverse topology in BL-algebras

پژوهش‌های ریاضی, 2020
In this paper, we introduce Inverse topology in a BL-algebra A and prove the set of all minimal prime filters of A, namely Min(A) with the Inverse topology is a compact space, Hausdorff, T0  and T1-Space.
Fereshteh Forouzesh, Farhad Sajadian, Mahta bedrood   +2 more
doaj  

The role of handicraft cooperatives in empowering the women of Qeshm Global Geopark [PDF]

فصلنامه زن و جامعه
Introduction:The tourism industry, as an industry that provides women access to job opportunities and economic participation, has played an important role in empowering women.
Farzaneh Haghighat ghahfarokhi, Amir abbas Najafipour   +1 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Architecture and conformational dynamics of the BAM-SurA holo insertase complex

Science Advances
The proper folding of outer membrane proteins in Gram-negative bacteria relies on their delivery to the β-barrel assembly machinery (BAM) complex. The mechanism by which survival protein A (SurA), the major periplasmic chaperone, facilitates this process is not well understood.
Philippe A. Lehner, Morris Degen, Roman P. Jakob, Seyed Majed Modaresi, Morgane Callon, Björn M. Burmann, Timm Maier, Sebastian Hiller   +7 more
openaire   +2 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

The model of creating an entrepreneurial attitude of tourism students (case study: tourism students of universities in Yazd province) [PDF]

Muṭāli̒āt-i Mudīriyyat-i Gardishgarī
The purpose of this research is to design a model for creating entrepreneurial attitudes among tourism students at universities in Yazd . The statistical population of this research includes two groups: tourism experts and tourism students from ...
Ali Saffari Darberazi, reza derakhshan, Morteza Bazrafshan, Ahmad Hajimoradi,   +3 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Apple Leaf Disease Identification in Complex Background Based on BAM-Net

Agronomy, 2023
Apples are susceptible to infection by various pathogens during growth, which induces various leaf diseases and thus affects apple quality and yield. The timely and accurate identification of apple leaf diseases is essential to ensure the high-quality development of the apple industry.
Yuxi Gao, Zhongzhu Cao, Weiwei Cai, Gufeng Gong, Guoxiong Zhou, Liujun Li   +5 more
openaire   +2 more sources

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source