Results 51 to 60 of about 5,482,674 (247)

Darobactin B Stabilises a Lateral‐Closed Conformation of the BAM Complex in E. coli Cells

Angewandte Chemie International Edition, 2023
AbstractThe β‐barrel assembly machinery (BAM complex) is essential for outer membrane protein (OMP) folding in Gram‐negative bacteria, and represents a promising antimicrobial target. Several conformational states of BAM have been reported, but all have been obtained under conditions which lack the unique features and complexity of the outer membrane ...
Haysom, SF, Machin, J, Whitehouse, JM, Horne, JE, Fenn, K, Ma, Y, El Mkami, H, Böhringer, N, Schäberle, TF, Ranson, NA, Radford, SE, Pliotas, C   +11 more
openaire   +8 more sources

State filters in state residuated lattices [PDF]

Categories and General Algebraic Structures with Applications, 2019
In this paper, we introduce the notions of prime state filters, obstinate state filters, and primary state filters in state residuated lattices and study some properties of them.
Zahra Dehghani, Fereshteh Forouzesh
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

genome/bam-readcount: v1.0.1 Release

, 2022
This release fixes: Correct version is now reported with --version (only works with cloned source: git clone -b v1.0.1 --single-branch git@github.com:genome/bam-readcount) Usage message now includes cram_file as well as bam_file The reviewers of the bam-
Susanna Kiwala, Eric J. Duncavage, Jason R. Walker, Matthew Mosior, Timothy J. Ley, Sridhar Nonavinkere Srivatsan, Malachi Griffith, Ajay Khanna^[co-first author], Travis E. Abbott, Matthew J. Walter, Obi L. Griffith, David E. Larson^[co-first author], Christopher A. Miller^[corresponding author]   +12 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Improve Efficiency of Photovoltaic/Thermal Systems using Porous Materials: An Experimental Study [PDF]

Iranica Journal of Energy and Environment
The weak convection mechanism in photovoltaic/thermal (PV/T) systems leads to numerous studies dealing with this problem. This study analyzes a new, affordable method to improve convection in PV/Ts and increase their thermal/electrical efficiency.
H. Farzan
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Targeting Proteus mirabilis BAM Complex Proteins for Development of Novel Antibiotics

Research Ideas and Outcomes, 2023
Urinary tract infections (UTIs) are frequent hospital-acquired infection, with Escherichia coli and Proteus mirabilis accounting for 90% of complicated UTIs. Emergence of multidrug-resistant (MDR) bacteria have complicated the treatment UTIs. P. mirabilis related UTIs has been associated with the production of urinary stones and long-term infections in
Raphael Abban, Kwabena Sarpong, Samuel Duodu, Lydia Mosi, Abiola Isawumi   +4 more
openaire   +3 more sources

Thermal Assessment of a Novel Thermal Diode Solar Water Heater Using Different Heat Transfer Fluids: An Experimental Study [PDF]

Iranica Journal of Energy and Environment
Thermal diode solar water heaters (SWHs) are novel, promising tools that address an inherent problem in SWHs: significant heat losses. Thermal diodes SWHs use heat transfer fluids (HTFs) to carry out this crucial task, or in other words, to improve the ...
H. Farzan
doaj   +1 more source

A novel fuzzy expert system design to assist with peptic ulcer disease diagnosis

Cogent Engineering, 2021
Peptic ulcer disease causes abdominal discomfort and pain. Helicobacter pylori bacteria, infection and long-term use of anti-inflammatory drugs are the most common causes of peptic ulcers.
Saeedreza Arab, Kianaz Rezaee, Ghazaleh Moghaddam   +2 more
doaj   +1 more source