Results 41 to 50 of about 2,137,571 (299)

Scale-dependent enstrophy production rates in a turbulent boundary layer

Journal of Fluid Science and Technology, 2019
Coarse-graining is indispensable for extracting a hierarchy of vortices in fully developed turbulent flow with multiscale nature. In the present study, for a high-Reynolds-number turbulent boundary layer, we employ two simple coarse-graining methods in ...
Yutaro MOTOORI, Susumu GOTO
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Design of Butterworth Band-Pass Filter [PDF]

, 2016
This paper presents a high order filter for the Butterworth filters up to 8th and 9th order. The higher order filters are formed by using the combination of second and third order filters. While designing the Band-Pass Butterworth filter, four parameters
Hussin, Siti Farah, Hamid, Zunainah, Birasamy, Gauri   +2 more
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Design of UWB Band-pass Filters with GPS Band Rejection

Journal of Measurement Science and Instrumentation, 2010
This paper presents a compact Ultra-Wideband（UWB）band-pass filter using a high-pass filter and a low-pass one,and the resonator with lumped elements.The structure of our proposed band-pass filter is very simple and the Defected Ground Structure（DGS ...
Seung-back JUNG, Seung-in YANG
doaj  

A Reconfigurable-Band Analog Filter Standard-Cell Based on Differential/Single Input Signaling

IEEE Access
This work presents a reconfigurable-band analog filter capable of performing the low-pass, high-pass, band-pass or all-pass functions. The proposed filter is a simple and compact cell composed of only two RC networks and one differential Operational ...
Alejandro Diaz-Sanchez, Gregorio Zamora-Mejia, Jose M. Rocha-Perez, Jose L. Vazquez-Gonzalez, Uriel G. Zapata-Rodriguez   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Multifunctional current-mode filter with dual-parameter control of the pole frequency

Advances in Electrical and Computer Engineering, 2016
This paper presents a multifunctional current-mode filter with dual-parameter control of the pole frequency. The filter is of the second order, of single-input triple-output (SITO) type and a required type of the response (low pass, inverting band pass,
JERABEK, J., DVORAK, J., SOTNER, R., METIN, B., VRBA, K.   +4 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source