Results 51 to 60 of about 2,049,581 (298)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Multifunctional current-mode filter with dual-parameter control of the pole frequency
Advances in Electrical and Computer Engineering, 2016 This paper presents a multifunctional current-mode filter with dual-parameter control of the pole frequency. The filter is of the second order, of single-input triple-output (SITO) type and a required type of the response (low pass, inverting band pass,
JERABEK, J. +4 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
An Ultra-Low-Power Front-End Neural Interface with Automatic Gain for Uncalibrated Monitoring [PDF]
, 2012 This paper presents a dynamic front-end towards achieving unsupervised single-neuron activity monitoring. By implementing at the front-end, an automatic gain control that is optimised for neural signal dynamics, subsequent processing can be achieved ...
Timothy G. Constandinou +3 more
core +1 more source
Iranian Journal of Electrical and Electronic Engineering, 2014 In this paper, a novel technique for the design of two-channel Quadrature Mirror Filter (QMF) banks with linear phase in frequency domain is presented. To satisfy the exact reconstruction condition of the filter bank, low-pass prototype filter response ...
S. K. Agrawal, O. P. Sahu
doaj
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
IEEE AccessWe proposed a folded line spoof surface plasmonic polaritons (SSPPs) waveguide that allows for efficient and strongly constrained microwave SSPPs transmission.
Siyu Yang +8 more
doaj +1 more source
Elektronika ir Elektrotechnika, 2018 The paper presents a novel solution of a fully-differential 1+α fractional-order filter. The filter can provide low-pass, high-pass, band-pass and band-stop transfer functions without a necessity of a circuitry change (filter is electronically ...
Lukas Langhammer +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Filtering Sinyal Menggunakan Band Pass Filter [PDF]
, 2018 In our daily lives we find many filters, filters from the word itself are filters. Filters vary, there are air filters to filter dirty air to be clean, filters / filters for coffee and tea to filter coffee or tea pulp, and so on.
Havis, Azhar Al, Fitria, Liza
core +1 more source