Results 31 to 40 of about 211 (103)

Strategic Preparedness of Broad‐Spectrum Antivirals for Rapid Response Towards Next Pandemics

Small Science, Volume 6, Issue 1, January 2026.
Nanoengineered broad‐spectrum antivirals (BSAs) represent a transformative approach to pandemic preparedness. Unlike virus‐specific drugs requiring separate development, BSAs act across multiple viral families through nanoengineering strategies that enhance solubility, bioavailability, and host‐targeted activity.
Sanoj Rejinold N, Geun‐woo Jin, Jin‐Ho Choy   +2 more
wiley   +1 more source

Integration of SFTSV Viral Load, Age, and Double‐Negative B‐Cells as Prognostic Biomarkers for Severe Fever With Thrombocytopenia Syndrome Outcomes

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Background Severe fever with thrombocytopenia syndrome (SFTS) is a tick‐borne viral illness with high mortality, yet early risk stratification remains challenging. Recent evidence suggests that B‐cell dysregulation contributes to disease severity. Methods A cohort of 168 patients with confirmed SFTS was retrospectively analyzed. Flow cytometry was used
Wei Wei, Qian Tai, Heng Liu, Rujia Chen, Yun Wang, Ting Wang, Renren Ouyang, Shiji Wu, Feng Wang, Hongyan Hou, Poorani Gurumallesh   +10 more
wiley   +1 more source

Epidemiological characteristics and viral molecular evolution analysis of severe fever with thrombocytopenia syndrome in Shandong Province, China

Ticks and Tick-Borne Diseases
Characterized by a high mortality rate and a widening global distribution, severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne emerging infectious disease spawned from the Bandavirus dabieense (DBV). Shandong Province emerges as one of the
Xiangjuan Chen, Yuwei Zhang, Qing Duan, Jiaqi Luo, Ruiqing Ma, Xiaomei Zhang, Bo Pang, Chunhong Yin, Xiaolin Jiang   +8 more
doaj   +1 more source

Table_1_TRIM3 attenuates cytokine storm caused by Dabie bandavirus via promoting Toll-like receptor 3 degradation.PDF

, 2023
BackgroundSevere fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease that was caused by the Dabie bandavirus (DBV), and it has become a global public health threat. Cytokine storm is considered to be an important pathogenesis of
Zhan Yang, Ke Jin (129426), Dafeng Lu, Chunhui Wang (141889), Jin Zhu (164147), Chunhui Wang, Huaying Huang (12425661), Ke Ouyang, Yan Dai (345965), Chunyan Wang, Ke Jin, Zhengyi Jiang, Jun Li, Nannan Hu, Xiaoguang Liu, Chunyan Wang (306606), Dafeng Lu (11660233), Jin Zhu, Jun Li (6494), Ke Ouyang (12425658), Hong Lin, Hong Lin (46089), Xuewei Sun, Huaying Huang, Zhengyi Jiang (6037655), Tingting Zhou, Xuewei Sun (14199572), Nannan Hu (8845373), Xiaoguang Liu (109982), Chuanlong Zhu (3966347), Chuanlong Zhu, Tingting Zhou (163678), Yan Dai, Zhan Yang (1627759)   +33 more
core   +1 more source

Molecular mechanism of potently neutralizing human monoclonal antibodies against severe fever with thrombocytopenia virus infection

Journal of Virology
Although severe fever with thrombocytopenia syndrome (SFTS) was first described in China in 2009, the case fatality rate remains >40% among patients with multi-organ failure. To date, no antivirals specifically targeting SFTSV have been approved.
Chuansong Quan, Kaixiao Nie, Dezhen Ma, Chao Su, Lianfeng Li, Wenjun Zheng, Chunhong Yin, Yiwen Wang, Peipei Yang, Dingkun Peng, Xin Liu, Weiwei Li, Weixiao Liu, Chao Shan, Jie Zheng, Di Liu, Hong Zhang, Michael J. Carr, George F. Gao, Jianxun Qi, Weifeng Shi   +20 more
doaj   +1 more source

Detection and prevalence of a novel Bandavirus related to Guertu virus in Amblyomma gemma ticks and human populations in Isiolo County, Kenya

Introduction: Emerging tick-borne viruses of medical and veterinary importance are increasingly being reported globally. This resurgence emphasizes the need for sustained surveillance to provide insights into tick-borne viral diversity and associated ...
Ongus, J.R., Oyola, Samuel O., Cherop, F., Rotich, G., Sang, R., Limbaso, K., Lutomiah, J., Koka, H., Ofula, V., Langat, S., Mutisya, J.   +10 more
core   +3 more sources

Exploration of immunological responses underpinning severe fever with thrombocytopenia syndrome virus infection reveals IL-6 as a therapeutic target in an immunocompromised mouse model [PDF]

, 2022
Dabie bandavirus (previously severe fever with thrombocytopenia syndrome virus; SFTSV) is an emerging tick-borne bunyavirus responsible for severe fever with thrombocytopenia syndrome (SFTS), a disease with high case fatality that is characterised by ...
Willett, Brian J, Brennan, Benjamin, Patel, Arvind H, Kohl, Alain, Patel, Arvind H., Gao, George F, Bryden, Steven R., Bryden, Steven R, Gao, George F., Dunlop, James I, Wu, Yan, Clarke, Andrew T, Dunlop, James I., Pingen, Marieke, Willett, Brian J., Clarke, Andrew T., Fares, Mazigh   +16 more
core   +1 more source

Residual and Late Onset Symptoms Appeared in a Patient with Severe Fever with Thrombocytopenia in a Convalescence Stage

, 2021
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease caused by Dabie bandavirus (formerly SFTS virus, SFTSV). Its manifestations during the convalescent phase have not been widely described.
Keiji Nakamura, Satoshi Kutsuna, Masayuki Shimojima, Ayako Okuhama, Kohei Kanda, Takeshi Kurosu, Norio Ohmagari, Akira Shimomura, Noriko Kinoshita, Tomoki Yoshikawa, Takeshi Inagaki, Masayuki Saijo   +11 more
core   +1 more source

Data_Sheet_1_Non-structural Proteins of Severe Fever With Thrombocytopenia Syndrome Virus Suppress RNA Synthesis in a Transcriptionally Active cDNA-Derived Viral RNA Synthesis System.PDF

, 2021
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by the tick-borne SFTS bunyavirus (SFTSV) resulting in a high fatality rate up to 30%.
Yun-Jia Ning (8605518), Hualin Wang (514306), Shu Shen (746509), Shiyu Dai (11276553), Min Zhou (173135), Fei Deng (170132), Fuli Ren (8685996), Junming Shi (11276556), Ding-Yu Zhang (9911148), Qiongya Wang (11276550), Chaolin Huang (9463406)   +10 more
core   +1 more source

Additional file 1 of Virome diversity shaped by genetic evolution and ecological landscape of Haemaphysalis longicornis

Additional file 1: Supplementary Table 1. Basic information of each library for sequencing in this study. Supplementary Table 2. Viral sequences of this study deposited in GenBank. Supplementary Table 3.
Jia-Fu Jiang (233262), Ning Wang (108353), Da-Li Xu (18000423), Xiao-Yang Wang (108249), Xiao-Ming Cui (5178833), Qing Xu (71204), Jing Liu (38537), Ze-Hui Li (533078), Ming-Zhu Zhang (10964007), Li-Feng Du (14308444), Shu-Jun Ding (293634), Run-Ze Ye (12345596), Yi-Di Du (18000432), Ke Song (705941), Lin Zhao (92451), Wan-Ying Gao (18000429), Hui-Jun Yu (479582), Wu-Chun Cao (69511), Bai-Hui Wang (18000426), Luo-Yuan Xia (14308441), Yi Sun (118759), Yu-Yu Li (9507225), Xiao-Yu Han (15355943), Nuo Cheng (9472327), Xiao-Yu Shi (14847676), Cheng Li (6339)   +25 more
core   +1 more source