Results 91 to 100 of about 268,877 (281)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Viscoelastic shear banding in foam

, 2008
Shear banding is an important feature of flow in complex fluids. Essentially, shear bands refer to the coexistence of flowing and non-flowing regions in driven material. Understanding the possible sources of shear banding has important implications for a
A. Kabla, Alexandre Kabla, C. Macosko, Kapilanjan Krishan, Michael Dennin, R. B. Bird   +5 more
core   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Fast transforms: Banded matrices with banded inverses [PDF]

Proceedings of the National Academy of Sciences, 2010
It is unusual for both A and A -1 to be banded—but this can be a valuable property in applications. Block-diagonal matrices F are the simplest examples; wavelet transforms are more subtle. We show that every example can be factored into A
openaire   +3 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

In vivo growing leporine model of pulmonary artery banding induces inflammation and vascular remodeling via pathways conserved across speciesCentral MessagePerspective

JTCVS Open
Objectives: Characterization of pulmonary artery banding in a growing leporine model with comparison to human tissue has yet to be published. We hypothesized that there would be inflammatory changes that occur to the myocardium despite small changes to ...
Danielle M. Mullis, BS, James Y. Lee, BA, Masafumi Shibata, MD, PhD, Veronica Toro Arana, MD, Sumanth Kidambi, MD, Amit Sharir, BS, Perry S. Choi, MD, Gentaro Ikeda, MD, PhD, Riya Nilkant, Hiroyuki Takashima, PhD, Tsuyoshi Ueyama, MS, Jay A. Huber, BS, MAB, Y. Joseph Woo, MD, Michael Ma, MD   +13 more
doaj   +1 more source

Northern Pintail (Anas acuta) survival, recovery, and harvest rates derived from 55 years of banding in Prairie Canada, 1960-2014

Avian Conservation and Ecology, 2017
Northern Pintail (Anas acuta; hereafter pintail) experienced a significant population decline in North America in the 1980s but did not rebound to the previous population level the way that other prairie dabbling duck species (Anas spp.) did once habitat
Blake A. Bartzen, Kevin W. Dufour
doaj   +1 more source

Banded transformer cores [PDF]

, 1974
A banded transformer core formed by positioning a pair of mated, similar core halves on a supporting pedestal. The core halves are encircled with a strap, selectively applying tension whereby a compressive force is applied to the core edge for reducing ...
Mclyman, C. W. T.
core   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source