Results 101 to 110 of about 107,242 (312)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Bessere Talententwicklung im Nachwuchsfussball [PDF]

open access: yes, 2018
What is bio-banding? During adolescents the biological age (BA) can vary up to five years among athletes with the same chronological age (CA). Bio-banding matches the training and competition groups according to BA rather than the CA.
Javet, Marie   +6 more
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

INFLUÊNCIA DO ANELAMENTO E ESTIOLAMENTO DE RAMOS NA PROPAGAÇÃO DA LARANJEIRA VALÊNCIA (Citrus sinensis Osbeck) ATRAVÉS DE ESTACAS

open access: yesScientia Agricola, 1996
Objetivando estudar a influência do condicionamento de ramos, através do anelamento e estiolamento parcial, sobre o enraizamento de estacas de laranjeira cv. Valência, conduziu-se o experimento no período de fevereiro a dezembro de 1993.
A.M. CASTRO, E. KERSTEN
doaj   +1 more source

The Missing Band [PDF]

open access: yesClinical Chemistry, 2014
Fig. 1. Serum immunofixation electrophoresis. Arrow denotes application point. Lanes labeled according to the antiserum applied (G, anti-IgG; D, anti-IgD; E, anti-IgE; K, total kappa; FKS, free kappa using antisera manufactured by Sebia; FKH, free kappa using antisera manufactured by Helena; L, total lambda; FLS, free lambda using antisera ...
openaire   +2 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Fast transforms: Banded matrices with banded inverses [PDF]

open access: yesProceedings of the National Academy of Sciences, 2010
It is unusual for both A and A -1 to be banded—but this can be a valuable property in applications. Block-diagonal matrices F are the simplest examples; wavelet transforms are more subtle. We show that every example can be factored into A
openaire   +4 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Home - About - Disclaimer - Privacy