Results 121 to 130 of about 107,242 (312)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Characterization of white grubs (Melolonthidae: Coleoptera) at salak pondoh agroecosystem in Mount Merapi based on isozymic banding patterns [PDF]

, 2009
Abstrak. Wardani S, Sugiyarto. 2009. Karakterisasi lundi putih (Melolonthidae: Coleoptera) pada agroekosistem salak pondoh di Gunung Merapi berdasarkan pola pita isozim. Nusantara Bioscience 1: 38-42.
WARDANI, SRI, WARDANI, S. (SRI), 1, S. (SUGIYARTO), SUGIYARTO,   +3 more
core  

The Impact of Multiple Thermal Cycles Using CMT^® on Microstructure Evolution in WAAM of Thin Walls Made of AlMg5

Metals
Wire Arc Additive Manufacturing (WAAM) of thin walls is an adequate technology for producing functional components made with aluminium alloys. The AlMg5 family is one of the most applicable alloys for WAAM.
Vinicius Lemes Jorge, Felipe Ribeiro Teixeira, Sten Wessman, Americo Scotti, Sergio Luiz Henke   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Identification for H-villosa chromatin in wheat lines using genomic in situ hybridization, C-banding and gliadin electrophoresis techniques [PDF]

, 2001
Detection of H. villosa chromosomes in telosomic addition and translocation lines of common wheat was undertaken using genomic in situ hybridization (GISH), C-banding techniques and polyacrylamide gels electrophoresis.
Yu, MQ, Ma, XR, Chen, J, Deng, GB, Cerbah, M, Yu, MQ, Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China., Panaud, O, Yakovlev, S   +7 more
core  

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Shear banding instabilities [PDF]

, 2010
Gradient-banding and vorticity-banding instabilities, as well as a shear-induced instability due to shear-gradient induced mass transport will be discussed.
Dhont, J. K. G., Dhont, J.K.G., Lettinga, M. P., Lettinga, M.P., Briels, W.J., Kang, K.   +5 more
core  

Commentary: To band or not to band—is that really the question? [PDF]

The Journal of Thoracic and Cardiovascular Surgery, 2021
openaire   +2 more sources

An Aortic Band [PDF]

European Journal of Vascular and Endovascular Surgery, 2021
Caitlin S. MacLeod, Rahul Velineni
openaire   +3 more sources