Reducing Youth Not in Employment, Education, or Training through JobStart Philippines [PDF]
, 2018 Key Points One in four young Filipinos are not in employment, education, or training. One in two young women with high school education or less are not in employment, education, or training.
Asian Development Bank
core +1 more source
Bank and sovereign debt risk connection : [draft december 2012] [PDF]
, 2012 Euro area data show a positive connection between sovereign and bank risk, which increases with banks’ and sovereign long run fragility. We build a macro model with banks subject to incentive problems and liquidity risk (in the form of liquidity based ...
Darracq Pariès, Matthieu +2 more
core +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Paving the Road to Better Income Options: Case Study on Promoting Women’s Livelihood and Employment Opportunities in Viet Nam [PDF]
, 2015 [Excerpt] Infrastructure projects and road networks have he potential to catalyze socioeconomic change. hey yield economic prospects for neighboring communities, enhance higher-value agricultural and industrial investment, and improve access to markets ...
Asian Development Bank
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Designing Central Bank Digital Currencies
Journal of Monetary Economics, 2019 We study the optimal design of a central bank digital currency (CBDC) in an environment where agents sort into cash, CBDC and bank deposits according to their preferences over anonymity and security; and where network effects make the convenience of ...
Itai Agur +2 more
semanticscholar +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Office of Anticorruption and Integrity: Annual Report 2013 [PDF]
, 2014 [Excerpt] Corruption is not single-celled. It does not move in just one direction and has many causes and symptoms. It has no single cure and will continue to grow and fester unless addressed from multiple fronts.
Asian Development Bank
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Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source
Pacific Economic Monitor: Budget Analysis [PDF]
, 2014 The Monitor provides an update of developments in Pacific economies and explores topical policy ...
Asian Development Bank
core +1 more source
Parallel application of a novel domain decomposition preconditioner for the adaptive finite-element solution of three-dimensional convection-dominated PDEs [PDF]
, 2003 We describe and analyse the parallel implementation of a novel domain decomposition preconditioner for the fast iterative solution of linear systems of algebraic equations arising from the discretization of elliptic partial differential equations (PDEs ...
Ashby +22 more
core +1 more source