Results 31 to 40 of about 4,401,243 (304)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Gender Mainstreaming Case Study - India: Chhattisgarh Irrigation Development Project [PDF]
, 2015 Project Goals and Results • The Chhattisgarh Irrigation Development Project (CIDP) aimed to increase agricultural productivity, improve rural livelihoods, and reduce poverty by improving irrigation delivery, enhancing agricultural practices, and ...
Asian Development Bank
core +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Az erőszak elmélete Leninnél és megvalósításának egyes fázisai a gyakorlatban
AxisAz erőszak az emberi történelemmel egyidős jelenség. Rengeteg formáját, megjelenését, típusát ismerjük, látjuk, halljuk és tapasztaljuk jelenünkben is.
Bank Barbara
doaj +1 more source
Current Objectives of Postgraduate American Studies, 2012 As an emancipating movement for women, the American Woman’s Rights Movement can be considered as a "counter public sphere" which transgressed dominant orders of gender.
Michaela Bank
doaj +1 more source
, 2008 The current global financial crisis grew out of banking losses in the United States related to subprime lending. How well do economists understand the origins of such crises and how they spread? Was this crisis something new or a replay of familiar historical phenomena? Will policy interventions be able to mitigate its costs?
openaire +3 more sources
Paving the Road to Better Income Options: Case Study on Promoting Women’s Livelihood and Employment Opportunities in Viet Nam [PDF]
, 2015 [Excerpt] Infrastructure projects and road networks have he potential to catalyze socioeconomic change. hey yield economic prospects for neighboring communities, enhance higher-value agricultural and industrial investment, and improve access to markets ...
Asian Development Bank
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Office of Anticorruption and Integrity: Annual Report 2013 [PDF]
, 2014 [Excerpt] Corruption is not single-celled. It does not move in just one direction and has many causes and symptoms. It has no single cure and will continue to grow and fester unless addressed from multiple fronts.
Asian Development Bank
core +1 more source
Quantitative easing: a rationale and some evidence from Japan [PDF]
, 2009 This paper reviews the rationale for quantitative easing when central bank policy rates reach near zero levels in light of recent announcements regarding direct asset purchases by the Bank of England, the Bank of Japan, the U.S.
Wieland, Volker
core +1 more source