Efficacy of natural killer T and gammadelta T cells in mesothelin-targeted immunotherapy of pancreatic cancer [PDF]
Frontiers in ImmunologyCurrent pancreatic cancer immunotherapy focused on alphabeta (αβ) T cells, either through CD3-engaged bispecific antibodies or CAR-T. Despite their promise, dose-limited toxicity (DLT) remains a challenge in clinical practice. In light of these concerns,
Yuankui Zhu +14 more
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Ageing and latent CMV infection impact on maturation, differentiation and exhaustion profiles of T-cell receptor gammadelta T-cells [PDF]
Scientific Reports, 2017 Ageing is a broad cellular process, largely affecting the immune system, especially T-lymphocytes. Additionally to immunosenescence alone, cytomegalovirus (CMV) infection is thought to have major impacts on T-cell subset composition and exhaustion. These
Martine J. Kallemeijn +7 more
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Expansion of Gammadelta T Cells from Cord Blood: A Therapeutical Possibility [PDF]
Stem Cells International, 2018 Gammadelta (γδ) T cells are found in both blood and tissues and have antiviral and antitumor properties. The frequency of γδ T cells in umbilical cord blood (UCB) is low, and the majority express δ1, in contrast to blood, whereas the main subset is δ2γ9 ...
Sofia Berglund +4 more
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Frontiers in Immunology, 2014 The success of gammadelta (gd) T cell-based immunotherapy, where the cytotoxic activity of circulating gd T lymphocytes is activated by nitrogen-containing bisphosphonates (n-BP), or possibly by bispecific antibodies or the combination of both, requires ...
Hans-Heinrich eOberg +7 more
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Obesity and cancer: the gammadelta T cell link
Exploration of Immunology, 2022 Obesity has become a worldwide scourge, affecting more than 10% of adults worldwide. While widely recognized to be associated with increased incidence of medical conditions such as diabetes mellitus and atherosclerosis, obesity also accounts for 9% of ...
Ilan Bank
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gammadelta T cells: the overlooked T-cell subset in demyelinating disease. [PDF]
J Neurosci Res, 2010 gammadelta T cells represent a small subpopulation of T cells expressing a restricted repertoire of T-cell receptors and, unlike alphabeta T cells, function more as cells of the innate immune system. These cells are found in skin and mucosal sites as well as secondary lymphoid tissues and frequently act as first line of defense sentinels.
Wohler JE, Smith SS, Barnum SR.
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IL-17-producing gammadelta T cells. [PDF]
Eur J Immunol, 2009 IL-17 is produced not only by CD4(+) alphabeta T cells, but also CD8(+) alphabeta T cells, NKT cells, and gammadelta T cells, plus some non-T cells, including macrophages and neutrophils. The ability of IL-17 to deploy neutrophils to sites of inflammation imparts this cytokine with a key role in diseases of several types.
O'Brien RL, Roark CL, Born WK.
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Generation and preclinical characterization of a novel bispecific CD19-TCRgammadelta antibody for the treatment of B cell acute lymphoblastic leukemia [PDF]
Frontiers in ImmunologyIntroductionB-cell acute lymphoblastic leukemia (B-ALL) is characterized by the clonal expansion of immature lymphoblastic cells. Treating patients with disease relapse is challenging, especially after allogeneic stem cell transplantation (aSCT ...
Joseph Kauer +22 more
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Gammadelta T cells are reduced and rendered unresponsive by hyperglycemia and chronic TNFalpha in mouse models of obesity and metabolic disease. [PDF]
PLoS ONE, 2010 Epithelial cells provide an initial line of defense against damage and pathogens in barrier tissues such as the skin; however this balance is disrupted in obesity and metabolic disease.
Kristen R Taylor +3 more
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NK cells and gammadelta T cells mediate resistance to polyomavirus-induced tumors. [PDF]
PLoS Pathogens, 2010 NK and gammadelta T cells can eliminate tumor cells in many experimental models, but their effect on the development of tumors caused by virus infections in vivo is not known.
Rabinarayan Mishra +3 more
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