Results 21 to 30 of about 13,834,757 (208)

Highly active microbial phosphoantigen induces rapid yet sustained MEK/Erk- and PI-3K/Akt-mediated signal transduction in anti-tumor human gammadelta T-cells.

open access: yesPLoS ONE, 2009
BackgroundThe unique responsiveness of Vgamma9Vdelta2 T-cells, the major gammadelta subset of human peripheral blood, to non-peptidic prenyl pyrophosphate antigens constitutes the basis of current gammadelta T-cell-based cancer immunotherapy strategies ...
Daniel V Correia   +8 more
doaj   +1 more source

Gammadelta T cell modulation in anticancer treatment.

open access: yesCurrent cancer drug targets, 2010
The broad antimicrobial and antitumoral reactivity of Vgamma9Vdelta2 T cells, their ability to produce inflammatory cytokines involved in protective immunity against intracellular pathogens and tumors and their strong cytolytic and bactericidal activities suggest their direct involvement in immune control of cancers and infections.
CACCAMO, Nadia Rosalia   +4 more
openaire   +3 more sources

Immune Profile of the Normal Maternal-Fetal Interface in Rhesus Macaques and Its Alteration Following Zika Virus Infection

open access: yesFrontiers in Immunology, 2021
The maternal decidua is an immunologically complex environment that balances maintenance of immune tolerance to fetal paternal antigens with protection of the fetus against vertical transmission of maternal pathogens.
Matilda J. Moström   +12 more
doaj   +1 more source

A dual role of inflammation in acetaminophen-induced liver injury

open access: yesLiver Research, 2023
In many affluent nations, acetaminophen (APAP) overdose is the leading cause of drug-induced acute liver failure. The process of APAP-induced liver injury (AILI) is intimately tied to inflammation, including hepatocyte necrosis-caused initiation of ...
Long Xu, Hua Wang
doaj   +1 more source

NK cells and gammadelta T cells mediate resistance to polyomavirus-induced tumors [PDF]

open access: yes, 2012
NK and gammadelta T cells can eliminate tumor cells in many experimental models, but their effect on the development of tumors caused by virus infections in vivo is not known.
Szomolanyi-Tsuda, Eva   +3 more
core   +1 more source

Gamma-delta T cells in glioblastoma immunotherapy

open access: yesGlioma, 2019
Conventional immunotherapy in the treatment of glioblastoma (GBM) has essentially produced no significant advantage over the use of chemotherapeutic drugs.
Sadhak Sengupta
doaj   +1 more source

Inhibitor of DNA binding 3 limits development of murine slam-associated adaptor protein-dependent "innate" gammadelta T cells.

open access: yesPLoS ONE, 2010
BackgroundId3 is a dominant antagonist of E protein transcription factor activity that is induced by signals emanating from the alphabeta and gammadelta T cell receptor (TCR).
Mihalis Verykokakis   +5 more
doaj   +1 more source

Comparable Vδ2 Cell Functional Characteristics in Virally Suppressed People Living with HIV and Uninfected Individuals

open access: yesCells, 2020
Crosstalk between innate and adaptive pathways is a critical component to developing an effective, lasting immune response. Among natural effector cells, innate-like γδ T cells promote immunity by facilitating communication between the two compartments ...
Matthew L. Clohosey   +6 more
doaj   +1 more source

Human γδ T-Cell Control of Mucosal Immunity and Inflammation

open access: yesFrontiers in Immunology, 2018
Human γδ T-cells include some of the most common “antigen-specific” cell types in peripheral blood and are enriched yet further at mucosal barrier sites where microbial infection and tumors often originate.
Neil E. McCarthy, Matthias Eberl
doaj   +1 more source

Transverse myelitis after anti‐CD19 directed CAR T cell therapy for relapsed large B cell lymphoma

open access: yes, 2022
eJHaem, Volume 3, Issue 1, Page 223-227, February 2022.
Semira Sheikh   +10 more
wiley   +1 more source

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