Results 21 to 30 of about 2,337 (177)

Highly active microbial phosphoantigen induces rapid yet sustained MEK/Erk- and PI-3K/Akt-mediated signal transduction in anti-tumor human gammadelta T-cells.

PLoS ONE, 2009
BackgroundThe unique responsiveness of Vgamma9Vdelta2 T-cells, the major gammadelta subset of human peripheral blood, to non-peptidic prenyl pyrophosphate antigens constitutes the basis of current gammadelta T-cell-based cancer immunotherapy strategies ...
Daniel V Correia, Francisco d'Orey, Bruno A Cardoso, Telma Lança, Ana R Grosso, Ana deBarros, Leila R Martins, João T Barata, Bruno Silva-Santos   +8 more
doaj   +1 more source

Increased cholesterol content in gammadelta (γδ) T lymphocytes differentially regulates their activation. [PDF]

PLoS ONE, 2013
Gammadelta (γδ) T lymphocytes respond quickly upon antigen encounter to produce a cytokine response. In this study, we sought to understand how functions of γδ T cells are differentially regulated compared to αβ T cells.
Hsin-Yuan Cheng, Runpei Wu, Abraham K Gebre, Richard N Hanna, Dan J Smith, John S Parks, Klaus Ley, Catherine C Hedrick   +7 more
doaj   +1 more source

A dual role of inflammation in acetaminophen-induced liver injury

Liver Research, 2023
In many affluent nations, acetaminophen (APAP) overdose is the leading cause of drug-induced acute liver failure. The process of APAP-induced liver injury (AILI) is intimately tied to inflammation, including hepatocyte necrosis-caused initiation of ...
Long Xu, Hua Wang
doaj   +1 more source

Gamma-delta T cells in glioblastoma immunotherapy

Glioma, 2019
Conventional immunotherapy in the treatment of glioblastoma (GBM) has essentially produced no significant advantage over the use of chemotherapeutic drugs.
Sadhak Sengupta
doaj   +1 more source

Correlation of memory T cell responses against TRAP with protection from clinical malaria, and CD4 CD25 high T cells with susceptibility in Kenyans.

PLoS ONE, 2008
BackgroundImmunity to malaria develops naturally in endemic regions, but the protective immune mechanisms are poorly understood. Many vaccination strategies aim to induce T cells against diverse pre-erythrocytic antigens, but correlates of protection in ...
Stephen M Todryk, Philip Bejon, Tabitha Mwangi, Magdalena Plebanski, Britta Urban, Kevin Marsh, Adrian V S Hill, Katie L Flanagan   +7 more
doaj   +1 more source

Inhibitor of DNA binding 3 limits development of murine slam-associated adaptor protein-dependent "innate" gammadelta T cells.

PLoS ONE, 2010
BackgroundId3 is a dominant antagonist of E protein transcription factor activity that is induced by signals emanating from the alphabeta and gammadelta T cell receptor (TCR).
Mihalis Verykokakis, Markus D Boos, Albert Bendelac, Erin J Adams, Pablo Pereira, Barbara L Kee   +5 more
doaj   +1 more source

Human γδ T-Cell Control of Mucosal Immunity and Inflammation

Frontiers in Immunology, 2018
Human γδ T-cells include some of the most common “antigen-specific” cell types in peripheral blood and are enriched yet further at mucosal barrier sites where microbial infection and tumors often originate.
Neil E. McCarthy, Matthias Eberl
doaj   +1 more source

Comparable Vδ2 Cell Functional Characteristics in Virally Suppressed People Living with HIV and Uninfected Individuals

Cells, 2020
Crosstalk between innate and adaptive pathways is a critical component to developing an effective, lasting immune response. Among natural effector cells, innate-like γδ T cells promote immunity by facilitating communication between the two compartments ...
Matthew L. Clohosey, Brendan T. Mann, Paul L. Ryan, Tatiyana V. Apanasovich, Sanjay B. Maggirwar, Daniel J. Pennington, Natalia Soriano-Sarabia   +6 more
doaj   +1 more source

Transverse myelitis after anti‐CD19 directed CAR T cell therapy for relapsed large B cell lymphoma

, 2022
eJHaem, Volume 3, Issue 1, Page 223-227, February 2022.
Semira Sheikh, Sepideh Mokhtari, Jeffrey A. Silverman, Kayla Reid, Rawan Faramand, Marco L. Davila, Norman Franke, Frederick L. Locke, Michael D. Jain, Daniel Wong, John G. Kuruvilla   +10 more
wiley   +1 more source

Gamma/Delta T Cells and Their Role in Protection Against Malaria

Frontiers in Immunology, 2018
Whether and how γδT cells play a protective role in immunity against Plasmodium infection remain open questions. γδT cells expand in patients and mice infected with Plasmodium spp, and cytokine production and cytotoxic responses against blood-stage ...
Katrien Deroost, Jean Langhorne
doaj   +1 more source