Results 21 to 30 of about 14,828,306 (213)

1.59 Reduced inflammatory potential of circulating gammadelta T cells in pregnancy induced improvement of Rheumatoid Arthritis [PDF]

, 2014
BACKGROUND AND OBJECTIVES During pregnancy, gammadelta T cells expand at the fetomaternal interface where they induce a tolerogenic milieu. Patients with rheumatoid arthritis (RA) experience a spontaneous improvement of their disease during pregnancy ...
Schlör, Gabriele, Tham, Manuela, Förger, Frauke, Villiger, Peter, Surbek, Daniel   +4 more
core   +1 more source

A dual role of inflammation in acetaminophen-induced liver injury

Liver Research, 2023
In many affluent nations, acetaminophen (APAP) overdose is the leading cause of drug-induced acute liver failure. The process of APAP-induced liver injury (AILI) is intimately tied to inflammation, including hepatocyte necrosis-caused initiation of ...
Long Xu, Hua Wang
doaj   +1 more source

Gamma-delta T cells in glioblastoma immunotherapy

Glioma, 2019
Conventional immunotherapy in the treatment of glioblastoma (GBM) has essentially produced no significant advantage over the use of chemotherapeutic drugs.
Sadhak Sengupta
doaj   +1 more source

Inhibitor of DNA binding 3 limits development of murine slam-associated adaptor protein-dependent "innate" gammadelta T cells.

PLoS ONE, 2010
BackgroundId3 is a dominant antagonist of E protein transcription factor activity that is induced by signals emanating from the alphabeta and gammadelta T cell receptor (TCR).
Mihalis Verykokakis, Markus D Boos, Albert Bendelac, Erin J Adams, Pablo Pereira, Barbara L Kee   +5 more
doaj   +1 more source

T cell receptor specificity is critical for the development of epidermal gammadelta T cells [PDF]

, 2001
A particular feature of gammadelta T cell biology is that cells expressing T cell receptor (TCR) using specific Vgamma/Vdelta segments are localized in distinct epithelial sites, e.g., in mouse epidermis nearly all gammadelta T cells express Vgamma3 ...
Wilson, A., Held, W., Ferrero, I., Beermann, F., MacDonald, H. R.   +4 more
core   +3 more sources

Correlation of memory T cell responses against TRAP with protection from clinical malaria, and CD4 CD25 high T cells with susceptibility in Kenyans.

PLoS ONE, 2008
BackgroundImmunity to malaria develops naturally in endemic regions, but the protective immune mechanisms are poorly understood. Many vaccination strategies aim to induce T cells against diverse pre-erythrocytic antigens, but correlates of protection in ...
Stephen M Todryk, Philip Bejon, Tabitha Mwangi, Magdalena Plebanski, Britta Urban, Kevin Marsh, Adrian V S Hill, Katie L Flanagan   +7 more
doaj   +1 more source

Comparable Vδ2 Cell Functional Characteristics in Virally Suppressed People Living with HIV and Uninfected Individuals

Cells, 2020
Crosstalk between innate and adaptive pathways is a critical component to developing an effective, lasting immune response. Among natural effector cells, innate-like γδ T cells promote immunity by facilitating communication between the two compartments ...
Matthew L. Clohosey, Brendan T. Mann, Paul L. Ryan, Tatiyana V. Apanasovich, Sanjay B. Maggirwar, Daniel J. Pennington, Natalia Soriano-Sarabia   +6 more
doaj   +1 more source

NK cells and gammadelta T cells mediate resistance to polyomavirus-induced tumors [PDF]

, 2012
NK and gammadelta T cells can eliminate tumor cells in many experimental models, but their effect on the development of tumors caused by virus infections in vivo is not known.
Szomolanyi-Tsuda, Eva, Mishra, Rabinarayan, Chen, Alex T., Welsh, Raymond M.   +3 more
core   +1 more source

T cell fate specification and alphabeta/gammadelta lineage commitment

, 2001
The development of T cells from pluripotent stem cells involves a coordinated series of lineage-commitment steps. Common lymphoid precursors in the fetal liver or adult bone marrow must first choose between a T, B or NK cell fate.
Radtke, F., Wilson, A., MacDonald, H.R., Wilson A, MacDonald HR, Radtke F, MacDonald, H. R., Anne Wilson, H.Robson MacDonald, Freddy Radtke   +9 more
core   +2 more sources

Human γδ T-Cell Control of Mucosal Immunity and Inflammation

Frontiers in Immunology, 2018
Human γδ T-cells include some of the most common “antigen-specific” cell types in peripheral blood and are enriched yet further at mucosal barrier sites where microbial infection and tumors often originate.
Neil E. McCarthy, Matthias Eberl
doaj   +1 more source