Results 11 to 20 of about 14,828,306 (213)

Highly active microbial phosphoantigen induces rapid yet sustained MEK/Erk- and PI-3K/Akt-mediated signal transduction in anti-tumor human gammadelta T-cells.

PLoS ONE, 2009
BackgroundThe unique responsiveness of Vgamma9Vdelta2 T-cells, the major gammadelta subset of human peripheral blood, to non-peptidic prenyl pyrophosphate antigens constitutes the basis of current gammadelta T-cell-based cancer immunotherapy strategies ...
Daniel V Correia, Francisco d'Orey, Bruno A Cardoso, Telma Lança, Ana R Grosso, Ana deBarros, Leila R Martins, João T Barata, Bruno Silva-Santos   +8 more
doaj   +2 more sources

Gammadelta T cell modulation in anticancer treatment.

Current cancer drug targets, 2010
The broad antimicrobial and antitumoral reactivity of Vgamma9Vdelta2 T cells, their ability to produce inflammatory cytokines involved in protective immunity against intracellular pathogens and tumors and their strong cytolytic and bactericidal activities suggest their direct involvement in immune control of cancers and infections.
CACCAMO, Nadia Rosalia, DIELI, Francesco, MERAVIGLIA, Serena, GUGGINO, Giuliana, SALERNO, Alfredo   +4 more
openaire   +4 more sources

Immunological Interactions Between Gammadelta T Cells and West Nile Virus in the Infected Host. [PDF]

Rev Med Virol
ABSTRACT Between mosquitoes and birds, West Nile virus (WNV) is a neurotropic flavivirus, an arthropod‐borne pathogen involved in an enzootic cycle. Additionally, it can infect both people and horses, leading to severe illness. Since 1999, WNV has spread across North and South America, including Mexico and the Caribbean.
Cimini E, Tartaglia E, Cristofanelli F, Gili S, Maggi F.   +4 more
europepmc   +2 more sources

SPP1 May Play an Important Role in the Carcinoid Nature of PAH. [PDF]

Mediators Inflamm
Objection Pulmonary arterial hypertension (PAH) was a cancer‐like disease. It shared several mechanisms, including perivascular inflammation. But the genes common and different between cancer and PAH was still unclear. We aimed to analyze the genes common in the two diseases, especially the N7‐methylguanosine (m7G) genes.
Huang Y, Yan S, Zhu J, Zhang W.
europepmc   +2 more sources

The CAR‐HEMATOTOX score identifies patients at high risk for hematological toxicity, infectious complications, and poor treatment outcomes following brexucabtagene autoleucel for relapsed or refractory MCL

American Journal of Hematology, Volume 98, Issue 11, Page 1699-1710, November 2023., 2023
The CAR‐HEMATOTOX risk‐stratifies for toxicity and survival in relapsed/refractory MCL. Abstract CD19‐directed CAR T‐cell therapy with brexucabtagene autoleucel (brexu‐cel) has substantially improved treatment outcomes for patients with relapsed/refractory mantle cell lymphoma (r/r MCL).
Kai Rejeski, Yucai Wang, Omar Albanyan, Javier Munoz, Pierre Sesques, Gloria Iacoboni, Lucia Lopez‐Corral, Isabelle Ries, Veit L. Bücklein, Razan Mohty, Martin Dreyling, Aliyah Baluch, Bijal Shah, Frederick L. Locke, Georg Hess, Pere Barba, Emmanuel Bachy, Yi Lin, Marion Subklewe, Michael D. Jain   +19 more
wiley   +1 more source

Inferior Outcomes of EU Versus US Patients Treated With CD19 CAR‐T for Relapsed/Refractory Large B‐cell Lymphoma: Association With Differences in Tumor Burden, Systemic Inflammation, Bridging Therapy Utilization, and CAR‐T Product Use

HemaSphere, Volume 7, Issue 8, August 2023., 2023
Real‐world evidence suggests a trend toward inferior survival of patients receiving CD19 chimeric antigen receptor (CAR) T‐cell therapy in Europe (EU) and with tisagenlecleucel. The underlying logistic, patient‐ and disease‐related reasons for these discrepancies remain poorly understood.
Veit Bücklein, Ariel Perez, Kai Rejeski, Gloria Iacoboni, Vindi Jurinovic, Udo Holtick, Olaf Penack, Soraya Kharboutli, Viktoria Blumenberg, Josephine Ackermann, Lisa Frölich, Grace Johnson, Kedar Patel, Brian Arciola, Rahul Mhaskar, Anthony Wood, Christian Schmidt, Omar Albanyan, Philipp Gödel, Eva Hoster, Lars Bullinger, Andreas Mackensen, Frederick Locke, Michael von Bergwelt, Pere Barba, Marion Subklewe, Michael D. Jain   +26 more
wiley   +1 more source

Performance of a PLK1‐based immune risk model for prognosis and treatment response prediction in breast cancer

Cancer Medicine, Volume 12, Issue 9, Page 11020-11039, May 2023., 2023
PLK1 regulated the degree of immune cell (e.g., CD8+ T cells, Tregs, etc.) infiltration and immunomodulator expressions, thus participating in the tumor‐specific immune response. The PLK1‐based immune risk model could accurately identify immunotherapy‐or chemotherapy‐sensitive breast cancer patients, which is expected to act as a biomarker for ...
Yan Chen, Yiqing You, Qiaoling Wu, Jing Wu, Shujing Lin, Yang Sun, Zhaolei Cui   +6 more
wiley   +1 more source

Surfing on the waves of the human γδ T cell ontogenic sea

Immunological Reviews, Volume 315, Issue 1, Page 89-107, May 2023., 2023
Summary While γδ T cells are present virtually in all vertebrates, there is a remarkable lack of conservation of the TRG and TRD loci underlying the generation of the γδ T cell receptor (TCR), which is associated with the generation of species‐specific γδ T cells.
Guillem Sanchez Sanchez, Yohannes Tafesse, Maria Papadopoulou, David Vermijlen   +3 more
wiley   +1 more source

Beta-selection: abundance of TCRbeta-/gammadelta- CD44- CD25- (DN4) cells in the foetal thymus. [PDF]

, 2007
Expression of TCRbeta and pre-TCR signalling are essential for differentiation of CD4- CD8- double negative (DN) thymocytes to the CD4+ CD8+ double-positive (DP) stage.
Outram, Susan V, Dessens, Johannes T, Nicola J. Rowbotham, Rowbotham, Nicola J, Tessa Crompton, Hager-Theodorides, Ariadne L, Ariadne L. Hager‐Theodorides, Susan V. Outram, Crompton, Tessa, Johannes T. Dessens   +9 more
core   +1 more source

Immune Profile of the Normal Maternal-Fetal Interface in Rhesus Macaques and Its Alteration Following Zika Virus Infection

Frontiers in Immunology, 2021
The maternal decidua is an immunologically complex environment that balances maintenance of immune tolerance to fetal paternal antigens with protection of the fetus against vertical transmission of maternal pathogens.
Matilda J. Moström, Matilda J. Moström, Elizabeth A. Scheef, Lesli M. Sprehe, Dawn Szeltner, Dollnovan Tran, Jon D. Hennebold, Victoria H. J. Roberts, Nicholas J. Maness, Nicholas J. Maness, Marissa Fahlberg, Amitinder Kaur, Amitinder Kaur   +12 more
doaj   +1 more source