Results 11 to 20 of about 13,834,757 (208)

Correlation of memory T cell responses against TRAP with protection from clinical malaria, and CD4 CD25 high T cells with susceptibility in Kenyans. [PDF]

PLoS ONE, 2008
BackgroundImmunity to malaria develops naturally in endemic regions, but the protective immune mechanisms are poorly understood. Many vaccination strategies aim to induce T cells against diverse pre-erythrocytic antigens, but correlates of protection in ...
Stephen M Todryk, Philip Bejon, Tabitha Mwangi, Magdalena Plebanski, Britta Urban, Kevin Marsh, Adrian V S Hill, Katie L Flanagan   +7 more
doaj   +2 more sources

Immunological Interactions Between Gammadelta T Cells and West Nile Virus in the Infected Host. [PDF]

Rev Med Virol
ABSTRACT Between mosquitoes and birds, West Nile virus (WNV) is a neurotropic flavivirus, an arthropod‐borne pathogen involved in an enzootic cycle. Additionally, it can infect both people and horses, leading to severe illness. Since 1999, WNV has spread across North and South America, including Mexico and the Caribbean.
Cimini E, Tartaglia E, Cristofanelli F, Gili S, Maggi F.   +4 more
europepmc   +2 more sources

SPP1 May Play an Important Role in the Carcinoid Nature of PAH. [PDF]

Mediators Inflamm
Objection Pulmonary arterial hypertension (PAH) was a cancer‐like disease. It shared several mechanisms, including perivascular inflammation. But the genes common and different between cancer and PAH was still unclear. We aimed to analyze the genes common in the two diseases, especially the N7‐methylguanosine (m7G) genes.
Huang Y, Yan S, Zhu J, Zhang W.
europepmc   +2 more sources

1.59 Reduced inflammatory potential of circulating gammadelta T cells in pregnancy induced improvement of Rheumatoid Arthritis [PDF]

, 2014
BACKGROUND AND OBJECTIVES During pregnancy, gammadelta T cells expand at the fetomaternal interface where they induce a tolerogenic milieu. Patients with rheumatoid arthritis (RA) experience a spontaneous improvement of their disease during pregnancy ...
Schlör, Gabriele, Tham, Manuela, Förger, Frauke, Villiger, Peter, Surbek, Daniel   +4 more
core   +2 more sources

The parasitic helminth product ES-62 suppresses pathogenesis in collagen-induced arthritis by targeting the interleukin-17–producing cellular network at multiple sites [PDF]

, 2012
Among many survival strategies, parasitic worms secrete molecules to modulate host immune responses. One such product, ES-62, is protective in the collagen-induced arthritis (CIA) model of rheumatoid arthritis.
Pineda, Miguel, Gracie, Alastair, McGrath, Mairi, Al-Riyami, Lamyaa, Rzepecka, Justyna, Harnett, Margaret, Smith, Pauline, Harnett, William   +7 more
core   +4 more sources

The CAR‐HEMATOTOX score identifies patients at high risk for hematological toxicity, infectious complications, and poor treatment outcomes following brexucabtagene autoleucel for relapsed or refractory MCL

American Journal of Hematology, Volume 98, Issue 11, Page 1699-1710, November 2023., 2023
The CAR‐HEMATOTOX risk‐stratifies for toxicity and survival in relapsed/refractory MCL. Abstract CD19‐directed CAR T‐cell therapy with brexucabtagene autoleucel (brexu‐cel) has substantially improved treatment outcomes for patients with relapsed/refractory mantle cell lymphoma (r/r MCL).
Kai Rejeski, Yucai Wang, Omar Albanyan, Javier Munoz, Pierre Sesques, Gloria Iacoboni, Lucia Lopez‐Corral, Isabelle Ries, Veit L. Bücklein, Razan Mohty, Martin Dreyling, Aliyah Baluch, Bijal Shah, Frederick L. Locke, Georg Hess, Pere Barba, Emmanuel Bachy, Yi Lin, Marion Subklewe, Michael D. Jain   +19 more
wiley   +1 more source

Inferior Outcomes of EU Versus US Patients Treated With CD19 CAR‐T for Relapsed/Refractory Large B‐cell Lymphoma: Association With Differences in Tumor Burden, Systemic Inflammation, Bridging Therapy Utilization, and CAR‐T Product Use

HemaSphere, Volume 7, Issue 8, August 2023., 2023
Real‐world evidence suggests a trend toward inferior survival of patients receiving CD19 chimeric antigen receptor (CAR) T‐cell therapy in Europe (EU) and with tisagenlecleucel. The underlying logistic, patient‐ and disease‐related reasons for these discrepancies remain poorly understood.
Veit Bücklein, Ariel Perez, Kai Rejeski, Gloria Iacoboni, Vindi Jurinovic, Udo Holtick, Olaf Penack, Soraya Kharboutli, Viktoria Blumenberg, Josephine Ackermann, Lisa Frölich, Grace Johnson, Kedar Patel, Brian Arciola, Rahul Mhaskar, Anthony Wood, Christian Schmidt, Omar Albanyan, Philipp Gödel, Eva Hoster, Lars Bullinger, Andreas Mackensen, Frederick Locke, Michael von Bergwelt, Pere Barba, Marion Subklewe, Michael D. Jain   +26 more
wiley   +1 more source

Performance of a PLK1‐based immune risk model for prognosis and treatment response prediction in breast cancer

Cancer Medicine, Volume 12, Issue 9, Page 11020-11039, May 2023., 2023
PLK1 regulated the degree of immune cell (e.g., CD8+ T cells, Tregs, etc.) infiltration and immunomodulator expressions, thus participating in the tumor‐specific immune response. The PLK1‐based immune risk model could accurately identify immunotherapy‐or chemotherapy‐sensitive breast cancer patients, which is expected to act as a biomarker for ...
Yan Chen, Yiqing You, Qiaoling Wu, Jing Wu, Shujing Lin, Yang Sun, Zhaolei Cui   +6 more
wiley   +1 more source

Surfing on the waves of the human γδ T cell ontogenic sea

Immunological Reviews, Volume 315, Issue 1, Page 89-107, May 2023., 2023
Summary While γδ T cells are present virtually in all vertebrates, there is a remarkable lack of conservation of the TRG and TRD loci underlying the generation of the γδ T cell receptor (TCR), which is associated with the generation of species‐specific γδ T cells.
Guillem Sanchez Sanchez, Yohannes Tafesse, Maria Papadopoulou, David Vermijlen   +3 more
wiley   +1 more source

The spliceosomal phosphopeptide P140 controls the lupus disease by interacting with the HSC70 protein and via a mechanism mediated by gammadelta T cells. [PDF]

PLoS ONE, 2009
The phosphopeptide P140 issued from the spliceosomal U1-70K snRNP protein is recognized by lupus CD4(+) T cells, transiently abolishes T cell reactivity to other spliceosomal peptides in P140-treated MRL/lpr mice, and ameliorates their clinical features.
Nicolas Page, Nicolas Schall, Jean-Marc Strub, Marc Quinternet, Olivier Chaloin, Marion Décossas, Manh Thong Cung, Alain Van Dorsselaer, Jean-Paul Briand, Sylviane Muller   +9 more
doaj   +1 more source