Results 41 to 50 of about 2,337 (177)

Neutrophils in cancer: At the crucial crossroads of anti‐tumor and pro‐tumor

Cancer Communications, Volume 45, Issue 8, Page 888-913, August 2025.
Abstract Neutrophils are important components of the immune system and play a key role in defending against pathogenic infections and responding to inflammatory cues, including cancer. Their dysregulation indicates potential disease risk factors. However, their functional importance in disease progression has often been underestimated due to their ...
Wenpeng Cai, Tao Fan, Chu Xiao, Ziqin Deng, Yixiao Liu, Chunxiang Li, Jie He   +6 more
wiley   +1 more source

Gamma/delta T cells as cellular vehicles for anti-tumor immunity

Frontiers in Immunology
Adoptive cellular immunotherapy as a new paradigm to treat cancers is exemplified by the FDA approval of six chimeric antigen receptor-T cell therapies targeting hematological malignancies in recent years.
Chelsia Qiuxia Wang, Pei Yu Lim, Andy Hee-Meng Tan, Andy Hee-Meng Tan   +3 more
doaj   +1 more source

Differential Skewing of Circulating MR1-Restricted and γδ T Cells in Human Psoriasis Vulgaris

Frontiers in Immunology, 2020
Psoriasis vulgaris (PV) is a chronic, recurrent inflammatory dermatosis mediated by aberrantly activated immune cells. The role of the innate-like T cells, particularly gammadelta T (γδT) cells and MR1-restricted T lymphocytes, is incompletely explored ...
Vera Plužarić, Vera Plužarić, Mario Štefanić, Martina Mihalj, Martina Mihalj, Maja Tolušić Levak, Maja Tolušić Levak, Ivanka Muršić, Ljubica Glavaš-Obrovac, Martin Petrek, Peter Balogh, Stana Tokić   +11 more
doaj   +1 more source

Harnessing the immunotherapeutic potentials of gamma delta T cells against hematological malignancies

HemaSphere, Volume 9, Issue 8, August 2025.
Abstract Gamma delta (γδ) T cells, which constitute about 5%–10% of peripheral blood lymphocytes, play key roles in tumor immunosurveillance and are often enriched within epithelial tissues. They are unique in their Major Histocompatibility Complex‐independent antigen recognition via the γδ T‐cell receptor (TCR) as well as via innate receptors, making ...
Charles Agbuduwe, John Maher, John Anderson   +2 more
wiley   +1 more source

Stimulatory and inhibitory activity of STING ligands on tumor-reactive human gamma/delta T cells

OncoImmunology, 2022
Ligands for Stimulator of Interferon Genes (STING) receptor are under investigation as adjuvants in cancer therapy. Multiple effects have been described, including induction of immunogenic cell death and enhancement of CD8 T-cell mediated anti-tumor ...
Ruben Serrano, Marcus Lettau, Michal Zarobkiewicz, Daniela Wesch, Christian Peters, Dieter Kabelitz   +5 more
doaj   +1 more source

γδ T LYMPHOCYTES AS A FIRST LINE OF IMMUNE DEFENSE: OLD AND NEW WAYS OF ANTIGEN RECOGNITION AND IMPLICATIONS FOR CANCER IMMUNOTHERAPY.

Frontiers in Immunology, 2014
Among γδT cells, the Vδ1 subset, resident in epithelial tissues, is implied in the defense against viruses, fungi and certain hematological malignancies, while the circulating Vδ2 subpopulation mainly respond to mycobacteria and solid tumors.
Maria Raffaella eZocchi, Alessandro ePoggi   +1 more
doaj   +1 more source

A Simple and Robust Single-Step Method for CAR-Vδ1 γδT Cell Expansion and Transduction for Cancer Immunotherapy

Frontiers in Immunology, 2022
The γδT cell subset of peripheral lymphocytes exhibits potent cancer antigen recognition independent of classical peptide MHC complexes, making it an attractive candidate for allogeneic cancer adoptive immunotherapy.
Gabrielle M. Ferry, Charles Agbuduwe, Megan Forrester, Sophie Dunlop, Kerry Chester, Jonathan Fisher, John Anderson, Marta Barisa   +7 more
doaj   +1 more source

Efficacy of Axicabtagene Ciloleucel Compared to Historical Treatments for Relapsed/Refractory Diffuse Large B‐Cell Lymphoma of Asian Descent: A Matching Adjusted Indirect Comparison of ZUMA‐1 vs REAL‐TREND

Hematological Oncology, Volume 43, Issue 3, May 2025.
ABSTRACT To better understand the comparative effectiveness of axicabtagene ciloleucel (axi‐cel) to historical standard of care (SoC) for the treatment of refractory diffused large B‐cell lymphoma (DLBCL) among patients of Asian descent, we conducted a matching‐adjusted indirect treatment comparison (MAIC) of the pivotal ZUMA‐1 trial (NCT02348216) and ...
Frederick L. Locke, Graeme Ball, Markqayne D. Ray, Tony Li, Eve H. Limbrick‐Oldfield, Evan Popoff, Steve Kanters   +6 more
wiley   +1 more source

Potential of gamma/delta T cells for solid tumor immunotherapy

Frontiers in Immunology
Gamma/delta T (γδ T)cells possess a unique mechanism for killing tumors, making them highly promising and distinguished among various cell therapies for tumor treatment.
Dantong Zhu, Xijing Ren, Xijing Ren, Wanting Xie, Jianjun Chen, Shiying Liang, Shiying Liang, Mingzhe Jiang, Junyi Wang, Zhendong Zheng   +9 more
doaj   +1 more source

Function and Spatial Organization of Tumor‐Invasive Human γδ T Cells—What Do We Know?

European Journal of Immunology, Volume 55, Issue 1, January 2025.
This review provides deeper insights into the localization of intra‐tumoral γδ T lymphocytes in solid tumors. Additionally, a pro‐ or anti‐tumoral influence of the tumor microenvironment and expression of checkpoint inhibitory molecules on γδ T cell functionality is described.
Kilian Wistuba‐Hamprecht, Hans‐Heinrich Oberg, Daniela Wesch   +2 more
wiley   +1 more source