Results 51 to 60 of about 13,834,757 (208)

Efficacy of Axicabtagene Ciloleucel Compared to Historical Treatments for Relapsed/Refractory Diffuse Large B‐Cell Lymphoma of Asian Descent: A Matching Adjusted Indirect Comparison of ZUMA‐1 vs REAL‐TREND

Hematological Oncology, Volume 43, Issue 3, May 2025.
ABSTRACT To better understand the comparative effectiveness of axicabtagene ciloleucel (axi‐cel) to historical standard of care (SoC) for the treatment of refractory diffused large B‐cell lymphoma (DLBCL) among patients of Asian descent, we conducted a matching‐adjusted indirect treatment comparison (MAIC) of the pivotal ZUMA‐1 trial (NCT02348216) and ...
Frederick L. Locke, Graeme Ball, Markqayne D. Ray, Tony Li, Eve H. Limbrick‐Oldfield, Evan Popoff, Steve Kanters   +6 more
wiley   +1 more source

Stimulatory and inhibitory activity of STING ligands on tumor-reactive human gamma/delta T cells

OncoImmunology, 2022
Ligands for Stimulator of Interferon Genes (STING) receptor are under investigation as adjuvants in cancer therapy. Multiple effects have been described, including induction of immunogenic cell death and enhancement of CD8 T-cell mediated anti-tumor ...
Ruben Serrano, Marcus Lettau, Michal Zarobkiewicz, Daniela Wesch, Christian Peters, Dieter Kabelitz   +5 more
doaj   +1 more source

Function and Spatial Organization of Tumor‐Invasive Human γδ T Cells—What Do We Know?

European Journal of Immunology, Volume 55, Issue 1, January 2025.
This review provides deeper insights into the localization of intra‐tumoral γδ T lymphocytes in solid tumors. Additionally, a pro‐ or anti‐tumoral influence of the tumor microenvironment and expression of checkpoint inhibitory molecules on γδ T cell functionality is described.
Kilian Wistuba‐Hamprecht, Hans‐Heinrich Oberg, Daniela Wesch   +2 more
wiley   +1 more source

UEG Week 2022 Poster Presentations

, 2022
United European Gastroenterology Journal, Volume 10, Issue S8, Page 473-1092, October 2022.
wiley   +1 more source

Increased cholesterol content in gammadelta (γδ) T lymphocytes differentially regulates their activation.

PLoS ONE, 2013
Gammadelta (γδ) T lymphocytes respond quickly upon antigen encounter to produce a cytokine response. In this study, we sought to understand how functions of γδ T cells are differentially regulated compared to αβ T cells.
Hsin-Yuan Cheng, Runpei Wu, Abraham K Gebre, Richard N Hanna, Dan J Smith, John S Parks, Klaus Ley, Catherine C Hedrick   +7 more
doaj   +1 more source

Human gammadelta T cells as mediators of chimaeric-receptor redirected anti-tumour immunity

Human peripheral blood gammadelta T cells (Vgamma9(+) Vdelta2(+)) can be selectively expanded in vivo by the systemic administration of aminobisphosphonates without prior antigen priming.
Duwe S, Rischer M, Jürgens H, Pscherer S, Rossig C, Vormoor J   +5 more
core   +5 more sources

Gamma/delta T cells as cellular vehicles for anti-tumor immunity

Frontiers in Immunology
Adoptive cellular immunotherapy as a new paradigm to treat cancers is exemplified by the FDA approval of six chimeric antigen receptor-T cell therapies targeting hematological malignancies in recent years.
Chelsia Qiuxia Wang, Pei Yu Lim, Andy Hee-Meng Tan, Andy Hee-Meng Tan   +3 more
doaj   +1 more source

A Simple and Robust Single-Step Method for CAR-Vδ1 γδT Cell Expansion and Transduction for Cancer Immunotherapy

Frontiers in Immunology, 2022
The γδT cell subset of peripheral lymphocytes exhibits potent cancer antigen recognition independent of classical peptide MHC complexes, making it an attractive candidate for allogeneic cancer adoptive immunotherapy.
Gabrielle M. Ferry, Charles Agbuduwe, Megan Forrester, Sophie Dunlop, Kerry Chester, Jonathan Fisher, John Anderson, Marta Barisa   +7 more
doaj   +1 more source

SOX‐5 Transcription Factor: a Novel Psoriatic Autoantigen Preferentially Found in Women

ACR Open Rheumatology, Volume 6, Issue 12, Page 807-819, December 2024.
Objective Adaptive immunity mediates psoriatic disease pathogenesis. We aimed to identify novel psoriatic autoantigens and their phenotypic associations in deeply characterized patient cohorts. Methods Sera from psoriatic arthritis (PsA) patients were used for autoantibody discovery.
Ana‐Maria Orbai, David Fiorentino, Jamie Perin, Erika Darrah, Qingyuan Yang, Laura Gutierrez‐Alamillo, Clifton O. Bingham, Michelle Petri, Antony Rosen, Livia Casciola‐Rosen   +9 more
wiley   +1 more source

Potential of gamma/delta T cells for solid tumor immunotherapy

Frontiers in Immunology
Gamma/delta T (γδ T)cells possess a unique mechanism for killing tumors, making them highly promising and distinguished among various cell therapies for tumor treatment.
Dantong Zhu, Xijing Ren, Xijing Ren, Wanting Xie, Jianjun Chen, Shiying Liang, Shiying Liang, Mingzhe Jiang, Junyi Wang, Zhendong Zheng   +9 more
doaj   +1 more source