Results 51 to 60 of about 14,828,306 (213)

Differential Skewing of Circulating MR1-Restricted and γδ T Cells in Human Psoriasis Vulgaris

Frontiers in Immunology, 2020
Psoriasis vulgaris (PV) is a chronic, recurrent inflammatory dermatosis mediated by aberrantly activated immune cells. The role of the innate-like T cells, particularly gammadelta T (γδT) cells and MR1-restricted T lymphocytes, is incompletely explored ...
Vera Plužarić, Vera Plužarić, Mario Štefanić, Martina Mihalj, Martina Mihalj, Maja Tolušić Levak, Maja Tolušić Levak, Ivanka Muršić, Ljubica Glavaš-Obrovac, Martin Petrek, Peter Balogh, Stana Tokić   +11 more
doaj   +1 more source

Function and Spatial Organization of Tumor‐Invasive Human γδ T Cells—What Do We Know?

European Journal of Immunology, Volume 55, Issue 1, January 2025.
This review provides deeper insights into the localization of intra‐tumoral γδ T lymphocytes in solid tumors. Additionally, a pro‐ or anti‐tumoral influence of the tumor microenvironment and expression of checkpoint inhibitory molecules on γδ T cell functionality is described.
Kilian Wistuba‐Hamprecht, Hans‐Heinrich Oberg, Daniela Wesch   +2 more
wiley   +1 more source

UEG Week 2022 Poster Presentations

, 2022
United European Gastroenterology Journal, Volume 10, Issue S8, Page 473-1092, October 2022.
wiley   +1 more source

Increased cholesterol content in gammadelta (γδ) T lymphocytes differentially regulates their activation.

PLoS ONE, 2013
Gammadelta (γδ) T lymphocytes respond quickly upon antigen encounter to produce a cytokine response. In this study, we sought to understand how functions of γδ T cells are differentially regulated compared to αβ T cells.
Hsin-Yuan Cheng, Runpei Wu, Abraham K Gebre, Richard N Hanna, Dan J Smith, John S Parks, Klaus Ley, Catherine C Hedrick   +7 more
doaj   +1 more source

A Simple and Robust Single-Step Method for CAR-Vδ1 γδT Cell Expansion and Transduction for Cancer Immunotherapy

Frontiers in Immunology, 2022
The γδT cell subset of peripheral lymphocytes exhibits potent cancer antigen recognition independent of classical peptide MHC complexes, making it an attractive candidate for allogeneic cancer adoptive immunotherapy.
Gabrielle M. Ferry, Charles Agbuduwe, Megan Forrester, Sophie Dunlop, Kerry Chester, Jonathan Fisher, John Anderson, Marta Barisa   +7 more
doaj   +1 more source

Gamma/delta T cells as cellular vehicles for anti-tumor immunity

Frontiers in Immunology
Adoptive cellular immunotherapy as a new paradigm to treat cancers is exemplified by the FDA approval of six chimeric antigen receptor-T cell therapies targeting hematological malignancies in recent years.
Chelsia Qiuxia Wang, Pei Yu Lim, Andy Hee-Meng Tan, Andy Hee-Meng Tan   +3 more
doaj   +1 more source

SOX‐5 Transcription Factor: a Novel Psoriatic Autoantigen Preferentially Found in Women

ACR Open Rheumatology, Volume 6, Issue 12, Page 807-819, December 2024.
Objective Adaptive immunity mediates psoriatic disease pathogenesis. We aimed to identify novel psoriatic autoantigens and their phenotypic associations in deeply characterized patient cohorts. Methods Sera from psoriatic arthritis (PsA) patients were used for autoantibody discovery.
Ana‐Maria Orbai, David Fiorentino, Jamie Perin, Erika Darrah, Qingyuan Yang, Laura Gutierrez‐Alamillo, Clifton O. Bingham, Michelle Petri, Antony Rosen, Livia Casciola‐Rosen   +9 more
wiley   +1 more source

Potential of gamma/delta T cells for solid tumor immunotherapy

Frontiers in Immunology
Gamma/delta T (γδ T)cells possess a unique mechanism for killing tumors, making them highly promising and distinguished among various cell therapies for tumor treatment.
Dantong Zhu, Xijing Ren, Xijing Ren, Wanting Xie, Jianjun Chen, Shiying Liang, Shiying Liang, Mingzhe Jiang, Junyi Wang, Zhendong Zheng   +9 more
doaj   +1 more source

γδ T LYMPHOCYTES AS A FIRST LINE OF IMMUNE DEFENSE: OLD AND NEW WAYS OF ANTIGEN RECOGNITION AND IMPLICATIONS FOR CANCER IMMUNOTHERAPY.

Frontiers in Immunology, 2014
Among γδT cells, the Vδ1 subset, resident in epithelial tissues, is implied in the defense against viruses, fungi and certain hematological malignancies, while the circulating Vδ2 subpopulation mainly respond to mycobacteria and solid tumors.
Maria Raffaella eZocchi, Alessandro ePoggi   +1 more
doaj   +1 more source

The expression of TCR-gamma delta/CD3 complex in neoplastic gamma delta T-cell

Haematologica, 2006
We describe that the neoplastic gammadelta T-cells from patients with hepatosplenic gammadelta T-cell lymphoma have a lower expression of TCR-gammadelta/CD3 complex compared to their normal or reactive counterparts.
L Baseggio, F Berger, G Monneret, JP Magaud, G Salles, P Felman   +5 more
doaj