Results 31 to 40 of about 2,337 (177)

Role of gammadelta T cells in protecting normal airway function

Respiratory Research, 2000
Since their discovery 15 years ago, the role of γδ T cells has remained somewhat elusive. Responses of γδ T cells have been found in numerous infectious and non-infectious diseases.
Gelfand Erwin W, O'Brien Rebecca L, Kanehiro Arihiko, Takeda Katsuyuki, Lahn Michael, Born Willi K   +5 more
doaj   +1 more source

Localized populations of CD8 MHC class I tetramer SIV-specific T cells in lymphoid follicles and genital epithelium. [PDF]

PLoS ONE, 2009
CD8 T cells play an important role in controlling viral infections. We investigated the in situ localization of simian immunodeficiency virus (SIV)-specific T cells in lymph and genital tissues from SIV-infected macaques using MHC-class I tetramers.
Jung Joo Hong, Matthew R Reynolds, Teresa L Mattila, Aaron Hage, David I Watkins, Christopher J Miller, Pamela J Skinner   +6 more
doaj   +1 more source

Endothelial dysfunction and proinflammatory state determine severe hematotoxicity and inferior outcome of CAR‐T therapy

HemaSphere, Volume 9, Issue 12, December 2025.
Abstract Hematotoxicity and infections are the main drivers of non‐relapse mortality after chimeric antigen receptor (CAR)‐T therapy. Consequently, reliable predictive biomarkers are highly needed to improve risk assessment and optimize patient management.
Lukas Scheller, Xiang Zhou, Henry Loeffler‐Wirth, Markus Kreuz, Sofie‐Katrin Kadel, Sven Schimanski, Hannah Schulze, Anna Ruckdeschel, Florian Eisele, Verena Konetzki, Maria Jornet Culubret, Maximilian Merz, Julia Mersi, Johannes Waldschmidt, Sophia Danhof, Ulrike Köhl, K. Martin Kortüm, Leo Rasche, Hermann Einsele, Johannes Düll, Max S. Topp, Michael Hudecek, Kristin Reiche, Miriam Alb   +23 more
wiley   +1 more source

Differentiation, distribution and gammadelta T cell-driven regulation of IL-22-producing T cells in tuberculosis.

PLoS Pathogens, 2010
Differentiation, distribution and immune regulation of human IL-22-producing T cells in infections remain unknown. Here, we demonstrated in a nonhuman primate model that M.
Shuyu Yao, Dan Huang, Crystal Y Chen, Lisa Halliday, Gucheng Zeng, Richard C Wang, Zheng W Chen   +6 more
doaj   +1 more source

Ontogeny of innate T lymphocytes - some innate lymphocytes are more innate then others

Frontiers in Immunology, 2014
Innate lymphocytes have recently received a lot of attention. However, there are different ideas about the definition of what is innate in lymphocytes. Lymphocytes without V(D)J-rearranged antigen receptors are now termed innate lymphoid cells (ILCs) and
David eVermijlen, Immo ePrinz
doaj   +1 more source

Galectin-3 Released by Pancreatic Ductal Adenocarcinoma Suppresses γδ T Cell Proliferation but Not Their Cytotoxicity

Frontiers in Immunology, 2020
Pancreatic ductal adenocarcinoma (PDAC) is characterized by an immunosuppressive tumor microenvironment with a dense desmoplastic stroma. The expression of β-galactoside-binding protein galectin-3 is regarded as an intrinsic tumor escape mechanism for ...
Daniel Gonnermann, Hans-Heinrich Oberg, Marcus Lettau, Matthias Peipp, Dirk Bauerschlag, Susanne Sebens, Dieter Kabelitz, Daniela Wesch   +7 more
doaj   +1 more source

γδ T Cells in Emerging Viral Infection: An Overview

Viruses, 2022
New emerging viruses belonging to the Coronaviridae, Flaviviridae, and Filoviridae families are serious threats to public health and represent a global concern.
Eleonora Cimini, Chiara Agrati
doaj   +1 more source

Accelerating Drug Development for Neuroblastoma: Consensus Statement From the Third Neuroblastoma Drug Development Strategy Forum

Pediatric Blood &Cancer, Volume 72, Issue 9, September 2025.
ABSTRACT High‐risk neuroblastoma is a poor prognosis cancer of the sympathetic nervous system that accounts for a disproportionate number of childhood cancer deaths. Many viable biological targets have been identified, and the number of potential combinations is even larger.
Steven G. DuBois, Lucas Moreno, John Anderson, Shahab Asgharzadeh, Ro Bagatell, Maja Beck‐Popovic, Jen Belle, Pablo Berlanga, Nick J. Bird, Louis Chesler, Adam Durbin, Angelika Eggert, Martin Eilers, Sara M. Federico, Matthias Fischer, Susanne A. Gatz, Rani E. George, Sally George, Kelly C. Goldsmith, Juliet Gray, Andras Heczey, Meredith S. Irwin, Leona Knox, Holger N. Lode, Donna Ludwinski, Margaret E. Macy, Robbie G. Majzner, John M. Maris, Shakeel Modak, Jan J. Molenaar, Daniel A. Morgenstern, Yael P. Mossé, Cormac Owens, C. Patrick Reynolds, Claudia Rossig, Gudrun Schleiermacher, Liz Scott, Paul M. Sondel, Frank Speleman, Max van Noesel, Frank Westermann, Judith Wienke, Adam J. Wolpaw, Julie R. Park, Andrew D. J. Pearson   +44 more
wiley   +1 more source

Gamma-delta (γδ) T cells: friend or foe in cancer development?

Journal of Translational Medicine, 2018
Background γδ T cells are a distinct subgroup of T cells containing T cell receptors (TCRs) γ and TCR δ chains with diverse structural and functional heterogeneity.
Yijing Zhao, Chao Niu, Jiuwei Cui
doaj   +1 more source

Characterization of human infiltrating and circulating gamma-delta T cells in prostate cancer [PDF]

Investigative and Clinical Urology, 2019
Purpose: The aim of our study was to prospectively evaluate the distribution of gamma-delta (γδ)1 and γδ2 T cells and their phenotypes in peripheral blood and prostate samples of patients diagnosed with or without prostate cancer (PCa) at prostate biopsy.
Marco Vella, Daniela Coniglio, Alberto Abrate, Cristina Scalici Gesolfo, Elena Lo Presti, Serena Meraviglia, Vincenzo Serretta, Alchiede Simonato   +7 more
doaj   +1 more source