Results 31 to 40 of about 13,834,757 (208)

The Role of Gammadelta T Cells and CD8+ Memory T Cells in Vaccinia Viral Infection

, 2021
Immune responses against viral infections are mediated through a complex process by diverse populations of cells, that can be harnessed for tumor immunotherapies and vaccinations.
Dai, Rui
core   +1 more source

Gamma/Delta T Cells and Their Role in Protection Against Malaria

Frontiers in Immunology, 2018
Whether and how γδT cells play a protective role in immunity against Plasmodium infection remain open questions. γδT cells expand in patients and mice infected with Plasmodium spp, and cytokine production and cytotoxic responses against blood-stage ...
Katrien Deroost, Jean Langhorne
doaj   +1 more source

In vivo application of mAb directed against the gammadelta TCR does not deplete but generates "invisible" gammadelta T cells.

, 2009
International audiencemAb targeting the gammadelta TCR have been used for gammadelta T-cell depletion with varying success. Although the depletion-capacity of the anti-gammadelta TCR mAb clone GL3 has been disputed repeatedly, many groups continue to use
Chennupati, Vijaykumar, Christian Koenecke, Bernard Malissen, Malissen, Bernard, Susanne Schmitz, Immo Prinz, Schmitz, Susanne, Koenecke, Christian, Förster, Reinhold, Vijaykumar Chennupati, Prinz, Immo, Reinhold Förster   +11 more
core   +1 more source

Immune Cell Responses to the Cattle Lungworm, Dictyocaulus viviparus [PDF]

, 2008
The cattle lungworm, Dictyocaulus viviparus, is a parasitic nematode, which can cause severe pulmonary disease. Repeated natural infections result in protective immunity, and a live attenuated vaccine exists.
Hagberg, Malin
core   +1 more source

Murine gammadelta T cells in infections: beneficial or deleterious?

, 2005
Although the importance of gammadelta T cells in pathogen-induced immune responses is becoming increasingly apparent, it is not clear that their involvement is always of benefit to the host.
Andrew, Elizabeth M., Simon R. Carding, Carding, Simon R., Elizabeth M. Andrew, Carding, Simon R, Andrew, Elizabeth M   +5 more
core   +1 more source

Role of gammadelta T cells in protecting normal airway function

Respiratory Research, 2000
Since their discovery 15 years ago, the role of γδ T cells has remained somewhat elusive. Responses of γδ T cells have been found in numerous infectious and non-infectious diseases.
Gelfand Erwin W, O'Brien Rebecca L, Kanehiro Arihiko, Takeda Katsuyuki, Lahn Michael, Born Willi K   +5 more
doaj   +1 more source

Endothelial dysfunction and proinflammatory state determine severe hematotoxicity and inferior outcome of CAR‐T therapy

HemaSphere, Volume 9, Issue 12, December 2025.
Abstract Hematotoxicity and infections are the main drivers of non‐relapse mortality after chimeric antigen receptor (CAR)‐T therapy. Consequently, reliable predictive biomarkers are highly needed to improve risk assessment and optimize patient management.
Lukas Scheller, Xiang Zhou, Henry Loeffler‐Wirth, Markus Kreuz, Sofie‐Katrin Kadel, Sven Schimanski, Hannah Schulze, Anna Ruckdeschel, Florian Eisele, Verena Konetzki, Maria Jornet Culubret, Maximilian Merz, Julia Mersi, Johannes Waldschmidt, Sophia Danhof, Ulrike Köhl, K. Martin Kortüm, Leo Rasche, Hermann Einsele, Johannes Düll, Max S. Topp, Michael Hudecek, Kristin Reiche, Miriam Alb   +23 more
wiley   +1 more source

Localized populations of CD8 MHC class I tetramer SIV-specific T cells in lymphoid follicles and genital epithelium. [PDF]

PLoS ONE, 2009
CD8 T cells play an important role in controlling viral infections. We investigated the in situ localization of simian immunodeficiency virus (SIV)-specific T cells in lymph and genital tissues from SIV-infected macaques using MHC-class I tetramers.
Jung Joo Hong, Matthew R Reynolds, Teresa L Mattila, Aaron Hage, David I Watkins, Christopher J Miller, Pamela J Skinner   +6 more
doaj   +1 more source

Accelerating Drug Development for Neuroblastoma: Consensus Statement From the Third Neuroblastoma Drug Development Strategy Forum

Pediatric Blood &Cancer, Volume 72, Issue 9, September 2025.
ABSTRACT High‐risk neuroblastoma is a poor prognosis cancer of the sympathetic nervous system that accounts for a disproportionate number of childhood cancer deaths. Many viable biological targets have been identified, and the number of potential combinations is even larger.
Steven G. DuBois, Lucas Moreno, John Anderson, Shahab Asgharzadeh, Ro Bagatell, Maja Beck‐Popovic, Jen Belle, Pablo Berlanga, Nick J. Bird, Louis Chesler, Adam Durbin, Angelika Eggert, Martin Eilers, Sara M. Federico, Matthias Fischer, Susanne A. Gatz, Rani E. George, Sally George, Kelly C. Goldsmith, Juliet Gray, Andras Heczey, Meredith S. Irwin, Leona Knox, Holger N. Lode, Donna Ludwinski, Margaret E. Macy, Robbie G. Majzner, John M. Maris, Shakeel Modak, Jan J. Molenaar, Daniel A. Morgenstern, Yael P. Mossé, Cormac Owens, C. Patrick Reynolds, Claudia Rossig, Gudrun Schleiermacher, Liz Scott, Paul M. Sondel, Frank Speleman, Max van Noesel, Frank Westermann, Judith Wienke, Adam J. Wolpaw, Julie R. Park, Andrew D. J. Pearson   +44 more
wiley   +1 more source

Beta-selection: abundance of TCRbeta-/gammadelta- CD44- CD25- (DN4) cells in the foetal thymus. [PDF]

, 2007
Expression of TCRbeta and pre-TCR signalling are essential for differentiation of CD4- CD8- double negative (DN) thymocytes to the CD4+ CD8+ double-positive (DP) stage.
Outram, Susan V, Dessens, Johannes T, Nicola J. Rowbotham, Rowbotham, Nicola J, Tessa Crompton, Hager-Theodorides, Ariadne L, Ariadne L. Hager‐Theodorides, Susan V. Outram, Crompton, Tessa, Johannes T. Dessens   +9 more
core   +1 more source