Results 1 to 10 of about 28,742 (86)

A clinical-grade automated platform for the manufacturing of CAR-γδ T cells for immunotherapy [PDF]

Frontiers in Immunology
Gamma delta (γδ) T cells are promising candidates for adoptive immunotherapy due to their unique biological and safety profiles. In particular, ex vivo expanded Vγ9Vδ2 T cells engineered with chimeric antigen receptors (CARs) have gained considerable ...
Jan Kuska, Julia Kostyra, Lorraine Pinot, Lorraine Pinot, Evgeny Egorov, Nojan Jelveh, Lilian A. Martinez Carrera, Congcong Zhang, Svetlana Khorkova, Mario Assenmacher, Rimas Orentas, Sabine Mueller, José Villacorta Hidalgo   +12 more
doaj   +2 more sources

T Helper Cells and Cytokine Networks in the Immunopathogenesis of Multiple Sclerosis [PDF]

ImmunoTargets and Therapy
Simeon Ikechukwu Egba,1,2 Gavin Chibundu Ikechukwu,2 Chinenye Iheanyi Okereke,2 Innocent Ogheneovo Orhonigbe,3 Robert Ikechukwu Uroko,2 Okechukwu Paul Chima Ugwu1 1Department of Biochemistry, Kampala International University, Kampala, Uganda; 2Department
Egba SI, Ikechukwu GC, Okereke CI, Orhonigbe IO, Uroko RI, Ugwu OPC   +5 more
doaj   +2 more sources

3D structures inferred from cDNA clones identify the CD1D-Restricted γδ T cell receptor in dromedaries

Frontiers in Immunology, 2022
The Camelidae species occupy an important immunological niche within the humoral as well as cell mediated immune response. Although recent studies have highlighted that the somatic hypermutation (SHM) shapes the T cell receptor gamma (TRG) and delta (TRD)
Giovanna Linguiti, Vincenzo Tragni, Ciro Leonardo Pierri, Serafina Massari, Marie-Paule Lefranc, Rachele Antonacci, Salvatrice Ciccarese   +6 more
doaj   +1 more source

Augmenting human gamma delta lymphocytes for cancer therapy with chimeric antigen receptors

Exploration of Immunology, 2022
Gamma delta lymphocytes (γδ T) sit at the interface between innate and adaptive immunity. They have the capacity to recognize cancer cells by interaction of their surface receptors with an array of cancer cell surface target antigens.
Gabrielle M. Ferry, John Anderson
doaj   +1 more source

High percentage of blood-based T-cell receptor gamma V9-JP recombinations associated with amyotrophic lateral sclerosis: extensive retention of the JP KKIK amino acid motif

Exploration of Immunology, 2023
Exome and RNAseq files prepared from blood samples can be mined for adaptive immune receptor recombinations and thus for the complementarity determining region-3 (CDR3) amino acid (AA) sequences, important for antigen binding.
George Blanck, Taha I. Huda, Konrad J. Cios, George Angelakakis, Joanna J. Song   +4 more
doaj   +1 more source

Target tumor microenvironment by innate T cells

Frontiers in Immunology, 2022
The immunosuppressive tumor microenvironment (TME) remains one of the most prevailing barriers obstructing the implementation of effective immunotherapy against solid-state cancers.
Yan-Ruide Li, Matthew Wilson, Lili Yang, Lili Yang, Lili Yang, Lili Yang   +5 more
doaj   +1 more source

Potent ex vivo armed T cells using recombinant bispecific antibodies for adoptive immunotherapy with reduced cytokine release

Journal for ImmunoTherapy of Cancer, 2021
Background T cell-based immunotherapies using chimeric antigen receptors (CAR) or bispecific antibodies (BsAb) have produced impressive responses in hematological malignancies.
Lawrence G Lum, Jeong A Park, Brian H Santich   +2 more
doaj   +1 more source

Adaptive Immune Responses and Immunity to SARS-CoV-2

Frontiers in Immunology, 2022
Since the onset of the COVID-19 pandemic, the medical field has been forced to apply the basic knowledge of immunology with the most up-to-date SARS-CoV-2 findings and translate it to the population of the whole world in record time.
Dragan Primorac, Dragan Primorac, Dragan Primorac, Dragan Primorac, Dragan Primorac, Dragan Primorac, Dragan Primorac, Dragan Primorac, Kristijan Vrdoljak, Petar Brlek, Eduard Pavelić, Vilim Molnar, Vid Matišić, Ivana Erceg Ivkošić, Ivana Erceg Ivkošić, Marijo Parčina   +15 more
doaj   +1 more source

A novel SARS-CoV-2 Beta RBD DNA vaccine directly targeted to antigen-presenting cells induces strong humoral and T cell responses

Scientific Reports, 2023
Throughout the COVID-19 pandemic, several variants of concern (VoC) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have evolved, affecting the efficacy of the approved COVID-19 vaccines.
Katarzyna Kuczkowska, Louise Bjerkan, Elisabeth Stubsrud, Hannah Cuthbertson Husbyn, Stalin Chellappa, Anette Hauge, Renate Skarshaug, Maria Lyngaas Torgersen, Joel Benjamin Heim, Marthe Jøntvedt Jørgensen, Christian Winther Wold, Mariane Høgsbjerg Schleimann, Martin Tolstrup, Stine Granum, Agnete Brunsvik Fredriksen, Mikkel Wandahl Pedersen, Gunnstein Norheim   +16 more
doaj   +1 more source

Clinical applications of gamma delta T cells with multivalent immunity

Frontiers in Immunology, 2014
Gamma delta T cells hold promise for adoptive immunotherapy because of their reactivity to bacteria, viruses, and tumors. However, these cells represent a small fraction (1-5%) of the peripheral T-cell pool and require activation and propagation to ...
Drew C Deniger, Judy S Moyes, Laurence JN Cooper   +2 more
doaj   +1 more source