Results 1 to 10 of about 27,293 (229)

A clinical-grade automated platform for the manufacturing of CAR-γδ T cells for immunotherapy [PDF]

Frontiers in Immunology
Gamma delta (γδ) T cells are promising candidates for adoptive immunotherapy due to their unique biological and safety profiles. In particular, ex vivo expanded Vγ9Vδ2 T cells engineered with chimeric antigen receptors (CARs) have gained considerable ...
Jan Kuska, Julia Kostyra, Lorraine Pinot, Lorraine Pinot, Evgeny Egorov, Nojan Jelveh, Lilian A. Martinez Carrera, Congcong Zhang, Svetlana Khorkova, Mario Assenmacher, Rimas Orentas, Sabine Mueller, José Villacorta Hidalgo   +12 more
doaj   +2 more sources

Antibody-gamma/delta T cell receptors targeting GPC2 regress neuroblastoma with low antigen density

Cell Reports Medicine
Summary: Chimeric antigen receptor (CAR) T cells have shown promise in hematological cancers but face challenges in solid tumors, partly due to heterogeneous antigen density. Glypican-2 (GPC2) is an oncofetal antigen highly expressed in neuroblastoma and
Alex Quan, Mingyu Huo, Dan Li, Laura E. Hutchins, Constanza Rodriguez, Jangsuk Oh, Hsi-En Tsao, Madeline Spetz, Elijah Edmondson, Dana Ashworth, Rui Zheng, Jing Zhou, Jinyun Chen, Jingbao Liu, Guangyan Xiong, Hongbing Zhang, Cheng Liu, Rosa Nguyen, Nan Li, Mitchell Ho   +19 more
doaj   +4 more sources

Harnessing the immunotherapeutic potentials of gamma delta T cells against hematological malignancies [PDF]

HemaSphere
Gamma delta (γδ) T cells, which constitute about 5%–10% of peripheral blood lymphocytes, play key roles in tumor immunosurveillance and are often enriched within epithelial tissues.
Charles Agbuduwe, John Maher, John Anderson   +2 more
doaj   +2 more sources

Temporal molecular remodeling of T cells informs their possible adaptation in 4T1 tumors [PDF]

Computational and Structural Biotechnology Journal
Background: The triple-negative breast cancer (TNBC) microenvironment undergoes progressive reprogramming, transitioning from an early immune-active state to a late immune-suppressed state.
Md. Iftehimul, Robert H. Newman, Scott H. Harrison, Roshonda B. Jones, Perpetua M. Muganda, Bryan L. Holloman, Muhammad T. Hossain, Checo J. Rorie, Misty D. Thomas, Joseph L. Graves, Jr., Howard L. Kaufman, Dipongkor Saha   +11 more
doaj   +2 more sources

3D structures inferred from cDNA clones identify the CD1D-Restricted γδ T cell receptor in dromedaries

Frontiers in Immunology, 2022
The Camelidae species occupy an important immunological niche within the humoral as well as cell mediated immune response. Although recent studies have highlighted that the somatic hypermutation (SHM) shapes the T cell receptor gamma (TRG) and delta (TRD)
Giovanna Linguiti, Vincenzo Tragni, Ciro Leonardo Pierri, Serafina Massari, Marie-Paule Lefranc, Rachele Antonacci, Salvatrice Ciccarese   +6 more
doaj   +1 more source

Augmenting human gamma delta lymphocytes for cancer therapy with chimeric antigen receptors

Exploration of Immunology, 2022
Gamma delta lymphocytes (γδ T) sit at the interface between innate and adaptive immunity. They have the capacity to recognize cancer cells by interaction of their surface receptors with an array of cancer cell surface target antigens.
Gabrielle M. Ferry, John Anderson
doaj   +1 more source

High percentage of blood-based T-cell receptor gamma V9-JP recombinations associated with amyotrophic lateral sclerosis: extensive retention of the JP KKIK amino acid motif

Exploration of Immunology, 2023
Exome and RNAseq files prepared from blood samples can be mined for adaptive immune receptor recombinations and thus for the complementarity determining region-3 (CDR3) amino acid (AA) sequences, important for antigen binding.
George Blanck, Taha I. Huda, Konrad J. Cios, George Angelakakis, Joanna J. Song   +4 more
doaj   +1 more source

Target tumor microenvironment by innate T cells

Frontiers in Immunology, 2022
The immunosuppressive tumor microenvironment (TME) remains one of the most prevailing barriers obstructing the implementation of effective immunotherapy against solid-state cancers.
Yan-Ruide Li, Matthew Wilson, Lili Yang, Lili Yang, Lili Yang, Lili Yang   +5 more
doaj   +1 more source

Selection of gamma delta T cells with canonical T-cell antigen receptors in fetal thymus. [PDF]

Proceedings of the National Academy of Sciences, 1990
Two gamma delta T-cell subsets that are generated in the fetal thymus and selectively localize in epidermis and uterus-vagina-tongue epithelia exhibit remarkable homogeneity in their (T-cell) antigen receptors (TCR). In the present study, we show that cells expressing the canonical gamma delta TCR are also generated in fetal thymus organ cultures ...
S, Itohara, S, Tonegawa
openaire   +2 more sources

Potent ex vivo armed T cells using recombinant bispecific antibodies for adoptive immunotherapy with reduced cytokine release

Journal for ImmunoTherapy of Cancer, 2021
Background T cell-based immunotherapies using chimeric antigen receptors (CAR) or bispecific antibodies (BsAb) have produced impressive responses in hematological malignancies.
Lawrence G Lum, Jeong A Park, Brian H Santich   +2 more
doaj   +1 more source