Results 31 to 40 of about 16,508,333 (245)

Structure and specificity of T cell receptor gamma/delta on major histocompatibility complex antigen-specific CD3+, CD4-, CD8- T lymphocytes. [PDF]

, 1988
Analyses of TCR-bearing murine and human T cells have defined a unique subpopulation of T cells that express the TCR-gamma/delta proteins. The specificity of TCR-gamma/delta T cells and their role in the immune response have not yet been elucidated. Here
Cron, RQ, Cotterman, M, J A Bluestone, M Cotterman, Matis, LA, B A Houlden, L A Matis, R Q Cron, Houlden, BA, Bluestone, JA   +9 more
core   +1 more source

Evidence for clonal selection of gamma/delta T cells in response to a human pathogen. [PDF]

, 1991
T cells bearing gamma/delta antigen receptors comprise a resident population of intraepithelial lymphocytes in organs such as skin, gut, and lungs, where they are strategically located to contribute to the initial defense against infection.
Band, H, K Uyemura, R J Deans, T H Rea, C T Morita, G Panchamoorthy, Uyemura, K, Deans, RJ, H Band, Panchamoorthy, G, R L Modlin, Modlin, RL, J Ohmen, Rea, TH, Ohmen, J, Morita, CT   +15 more
core   +1 more source

The Vγ9Vδ2 T cell antigen receptor and butyrophilin 3 A1 (BTN3A1): Models of interaction, the possibility of co-evolution, and the case of dendritic epidermal T cells

Frontiers in Immunology, 2014
Most circulating human gamma delta T cells are Vγ9Vδ2 T cells. Their hallmark is the expression of T cell antigen receptors (TCR) whose γ-chains show a Vγ9-JP (Vγ2-Jγ1.2) rearrangement and are paired with Vδ2 containing δ-chains, a dominant TCR ...
Mohindar Murugesh eKarunakaran, Thomas eHerrmann   +1 more
doaj   +1 more source

Five layers of receptor signalling in γδ T cell differentiation and activation [PDF]

, 2015
The contributions of gamma-delta T cells to immunity to infection or tumours critically depend on their activation and differentiation into effectors capable of secreting cytokines and killing infected or transformed cells.
Sérgio T. Ribeiro, Ribot, Julie, Silva-Santos, Bruno, Sérgio T. Ribeiro, Bruno eSilva-Santos, Ribeiro, Sérgio T, Julie C. Ribot, Bruno Silva-Santos   +7 more
core   +1 more source

Ligand-induced segregation from large cell-surface phosphatases is a critical step in γδ TCR triggering

Cell Reports
Summary: Gamma/delta (γδ) T cells are unconventional lymphocytes that recognize diverse ligands via somatically recombined T cell antigen receptors (γδ TCRs). The molecular mechanism by which ligand recognition initiates γδ TCR signaling, a process known
Fenglei Li, Sobhan Roy, Jacob Niculcea, Keith Gould, Erin J. Adams, P. Anton van der Merwe, Kaushik Choudhuri   +6 more
doaj   +1 more source

Chimeric antigen receptor T cells for gamma–delta T cell malignancies [PDF]

Leukemia, 2021
P. A. Wawrzyniecka, L. Ibrahim, G. Gritti, M. A. Pule, P. M. Maciocia   +4 more
openaire   +3 more sources

Bovine gamma/delta T cells are stimulated by bovine coronavirus antigens identified by a soluble T cells receptor [PDF]

Medycyna Weterynaryjna, 2017
Gamma/delta (γδ) T cells in cattle account for an abundant T cell population. However, little is known regarding the function of γδ T cells as immune cells compared to αβ T cells. Not many pathogen-related antigens have been defined and known to stimulate γδ T cells.
openaire   +1 more source

The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules [PDF]

, 1992
Recent studies have demonstrated that the CD3-ζ subunit of the T cell antigen receptor (TCR) complex is involved in signal transduction. However, the function of the remaining invariant subunits, CD3-γ, -δ, and , is still poorly understood.
Wegener, Anne-Marie K., Bernard Malissen, Malissen, Bernard, Frederle Luton, Brocker, Thomas, Frédéric Luton, François Letourneur, Frant :is Letourneur, Letourneur, François, Anne-marie K. Wegener, Thomas Brocker, Letourneur, F., Arnd Hoeveler, Thomas Broeker, Brocker, T., Hoeveler, Arnd, Wegener, Am, Hoeveler, A., Luton, Frédéric, Luton, F.   +19 more
core   +1 more source

Somatic Evolution of a Germline Antibody Expands its Breadth to Neutralize Early SARS‐CoV‐2 Omicron Variants

Advanced Science, EarlyView.
Engineering of the 148‐germline (148‐GL) antibody reveals a roadmap for overcoming SARS‐CoV‐2 viral escape. By introducing four specific somatic hypermutations, the resulting 148‐M4 variant restores potent neutralization against Omicron BA.1 and BA.4/5.
Huibin Lv, Ziqi Feng, Qi Wen Teo, Chunke Chen, Akshita B. Gopal, Danbi Choi, Timothy J. C. Tan, Yun Sang Tang, Lewis Siu, Armita Nourmohammad, Roberto Bruzzone, Ian A. Wilson, Meng Yuan, Nicholas C. Wu, Chris K. P. Mok   +14 more
wiley   +1 more source

Human Vδ2 T Cells and Their Versatility for Immunotherapeutic Approaches

, 2022
Gamma/delta (γδ) T cells are innate-like immune effectors that are a critical component linking innate and adaptive immune responses. They are recognized for their contribution to tumor surveillance and fight against infectious diseases ...
Marta Sanz, Soriano-Sarabia, Natalia, Sanz, Marta, Chitrakar, Alisha, Brendan T. Mann, Natalia Soriano-Sarabia, Alisha Chitrakar, Mann, Brendan T., Mann, Brendan T   +8 more
core   +1 more source