Bradykinin B2 receptors of dendritic cells, acting as sensors of kinins proteolytically released by Trypanosoma cruzi, are critical for the development of protective type-1 responses [PDF]
, 2007 Although the concept that dendritic cells (DCs) recognize pathogens through the engagement of Toll-like receptors is widely accepted, we recently suggested that immature DCs might sense kinin-releasing strains of Trypanosoma cruzi through the triggering ...
Müller-Esterl Werner +29 more
core +2 more sources
Phenotypic and functional analysis of positive selection in the gamma/delta T cell lineage. [PDF]
, 1993 Recent evidence suggests that T cells expressing gamma/delta antigen receptors (T cell receptor [TCR]) are subject to positive selection during development.
J P Allison +11 more
core +1 more source
Rejection of Experimental Hodgkins Lymphoma by T-cells Engineered with a CD19 Chimeric Antigen Receptor [PDF]
, 2012 T cells engineered to express chimeric receptors combining an external antibody binding domain with the CD3ζ T cell receptor (TCR) internal domain for triggering cell activation are being used for immunotherapeutic targeting of tumour cells in a non-HLA ...
Cheadle, Eleanor +8 more
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Apoptosis Induced via Gamma Delta T Cell Antigen Receptor “Blocking” Antibodies: A Cautionary Tale [PDF]
Frontiers in Immunology, 2017 Mechanistic studies contribute greatly to our understanding of γδ T cell (γδTc) biology, aiding development of these cells as immunotherapeutic agents. The antibody blocking assay is an accepted method to determine the receptors involved in γδTc killing of tumor targets.
Dutta, Indrani +2 more
openaire +3 more sources
Studies on the affinity control of T cell development [PDF]
, 2004 Defined interactions between thymocytes and thymic antigen presenting cells ensure that each T cell found in an individual is both self-restricted and self-tolerant.
Naeher, Dieter
core +1 more source
Preferential usage of the Fc receptor gamma chain in the T cell antigen receptor complex by gamma/delta T cells localized in epithelia. [PDF]
The Journal of experimental medicine, 1994 zeta and eta chains of the T cell antigen receptor (TCR) complex and the gamma chain of Fc receptors (FcR gamma) constitute a family of proteins important for the expression of, and signal transduction through, these receptors in hematopoietic cells. In zeta-deficient mice, TCR expression was reduced in most T cells.
H, Ohno +4 more
openaire +2 more sources
NK and T cells constitute two major, functionally distinct intestinal epithelial lymphocyte subsets in the chicken [PDF]
, 2001 Non-mammalian NK cells have not been characterized in detail; however, their analysis is essential for the understanding of the NK cell receptor phylogeny.
Manfred Stangassinger +5 more
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Differential segregation in a cell-cell contact interface: the dynamics of the immunological synapse [PDF]
, 2002 Receptor-ligand couples in the cell-cell contact interface between a T cell and an antigen-presenting cell form distinct geometric patterns and undergo spatial rearrangement within the contact interface.
Nigel John Burroughs +3 more
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Extrathymic origin of intestinal intraepithelial lymphocytes bearing T-cell antigen receptor gamma delta. [PDF]
Proceedings of the National Academy of Sciences, 1991 The kinetics of postnatal intestinal colonization by T cells carrying gamma delta and alpha beta T-cell antigen receptors were studied in nude and normal mice by flow cytometry and immunohistology. Furthermore, gamma delta and alpha beta T-cell development was analyzed in lethally irradiated mice that were reconstituted by fetal liver precursors with ...
A, Bandeira +6 more
openaire +2 more sources
, 2010 To clarify the difference between gene expression signature of Epstein-Barr virus (EBV)-positive gamma delta T-cell lymphoproliferative disorders (LPD) and those in normal gamma delta T-cells, we set out to determine gene expression profiling using three
Zhang, Yu +7 more
core +1 more source