Results 11 to 20 of about 27,293 (229)

Adaptive Immune Responses and Immunity to SARS-CoV-2

Frontiers in Immunology, 2022
Since the onset of the COVID-19 pandemic, the medical field has been forced to apply the basic knowledge of immunology with the most up-to-date SARS-CoV-2 findings and translate it to the population of the whole world in record time.
Dragan Primorac, Dragan Primorac, Dragan Primorac, Dragan Primorac, Dragan Primorac, Dragan Primorac, Dragan Primorac, Dragan Primorac, Kristijan Vrdoljak, Petar Brlek, Eduard Pavelić, Vilim Molnar, Vid Matišić, Ivana Erceg Ivkošić, Ivana Erceg Ivkošić, Marijo Parčina   +15 more
doaj   +1 more source

A novel SARS-CoV-2 Beta RBD DNA vaccine directly targeted to antigen-presenting cells induces strong humoral and T cell responses

Scientific Reports, 2023
Throughout the COVID-19 pandemic, several variants of concern (VoC) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have evolved, affecting the efficacy of the approved COVID-19 vaccines.
Katarzyna Kuczkowska, Louise Bjerkan, Elisabeth Stubsrud, Hannah Cuthbertson Husbyn, Stalin Chellappa, Anette Hauge, Renate Skarshaug, Maria Lyngaas Torgersen, Joel Benjamin Heim, Marthe Jøntvedt Jørgensen, Christian Winther Wold, Mariane Høgsbjerg Schleimann, Martin Tolstrup, Stine Granum, Agnete Brunsvik Fredriksen, Mikkel Wandahl Pedersen, Gunnstein Norheim   +16 more
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Chimeric Antigen Receptor-Engineered Human Gamma Delta T Cells: Enhanced Cytotoxicity with Retention of Cross Presentation [PDF]

Molecular Therapy, 2018
Gamma delta T (γδT) lymphocytes are primed for rapid function, including cytotoxicity toward cancer cells, and are a component of the immediate stress response. Following activation, they can function as professional antigen-presenting cells. Chimeric antigen receptors (CARs) work by focusing T cell function on defined cell surface tumor antigens and ...
Capsomidis, A, Benthall, G, Van Acker, HH, Fisher, J, Kramer, AM, Abeln, Z, Majani, Y, Gileadi, T, Wallace, R, Gustafsson, K, Flutter, B, Anderson, J   +11 more
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Clinical applications of gamma delta T cells with multivalent immunity

Frontiers in Immunology, 2014
Gamma delta T cells hold promise for adoptive immunotherapy because of their reactivity to bacteria, viruses, and tumors. However, these cells represent a small fraction (1-5%) of the peripheral T-cell pool and require activation and propagation to ...
Drew C Deniger, Judy S Moyes, Laurence JN Cooper   +2 more
doaj   +1 more source

Chimeric Antigen Receptor T-Cells for the Treatment of Gamma-Delta T-Cell Malignancies

Blood, 2018
Abstract Introduction Cancers derived from the malignant transformation of gamma delta T-cells are rare but carry very poor prognosis. Hepatosplenic T-cell lymphoma is a highly aggressive condition characterised by hepatosplenic and bone marrow involvement.
Paul Maciocia, Patrycja Wawrzyniecka, Leo Kassimatis, Martin Pule   +3 more
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Mixing signals: Molecular turn ons and turn offs for innate γδ Τ cells

Frontiers in Immunology, 2014
Lymphocytes of the gamma delta (γδ) T cell lineage are evolutionary conserved and although they express rearranged antigen-specific receptors a large proportion respond as innate effectors. γδ T cells are poised to combat infection by responding rapidly
Vasileios eBekiaris, Vasileios eBekiaris, John S Šedý, Carl F Ware   +3 more
doaj   +1 more source

Apoptosis Induced via Gamma Delta T Cell Antigen Receptor “Blocking” Antibodies: A Cautionary Tale [PDF]

Frontiers in Immunology, 2017
Mechanistic studies contribute greatly to our understanding of γδ T cell (γδTc) biology, aiding development of these cells as immunotherapeutic agents. The antibody blocking assay is an accepted method to determine the receptors involved in γδTc killing of tumor targets.
Dutta, Indrani, Postovit, Lynne-Marie, Siegers, Gabrielle M.   +2 more
openaire   +3 more sources

Preferential usage of the Fc receptor gamma chain in the T cell antigen receptor complex by gamma/delta T cells localized in epithelia. [PDF]

The Journal of experimental medicine, 1994
zeta and eta chains of the T cell antigen receptor (TCR) complex and the gamma chain of Fc receptors (FcR gamma) constitute a family of proteins important for the expression of, and signal transduction through, these receptors in hematopoietic cells. In zeta-deficient mice, TCR expression was reduced in most T cells.
H, Ohno, S, Ono, N, Hirayama, S, Shimada, T, Saito   +4 more
openaire   +2 more sources

Extrathymic origin of intestinal intraepithelial lymphocytes bearing T-cell antigen receptor gamma delta. [PDF]

Proceedings of the National Academy of Sciences, 1991
The kinetics of postnatal intestinal colonization by T cells carrying gamma delta and alpha beta T-cell antigen receptors were studied in nude and normal mice by flow cytometry and immunohistology. Furthermore, gamma delta and alpha beta T-cell development was analyzed in lethally irradiated mice that were reconstituted by fetal liver precursors with ...
A, Bandeira, S, Itohara, M, Bonneville, O, Burlen-Defranoux, T, Mota-Santos, A, Coutinho, S, Tonegawa   +6 more
openaire   +2 more sources

Bovine gamma/delta T cells are stimulated by bovine coronavirus antigens identified by a soluble T cells receptor [PDF]

Medycyna Weterynaryjna, 2017
Gamma/delta (γδ) T cells in cattle account for an abundant T cell population. However, little is known regarding the function of γδ T cells as immune cells compared to αβ T cells. Not many pathogen-related antigens have been defined and known to stimulate γδ T cells.
openaire   +1 more source