Results 11 to 20 of about 16,508,333 (245)

Antibody-gamma/delta T cell receptors targeting GPC2 regress neuroblastoma with low antigen density

Cell Reports Medicine
Summary: Chimeric antigen receptor (CAR) T cells have shown promise in hematological cancers but face challenges in solid tumors, partly due to heterogeneous antigen density. Glypican-2 (GPC2) is an oncofetal antigen highly expressed in neuroblastoma and
Alex Quan, Mingyu Huo, Dan Li, Laura E. Hutchins, Constanza Rodriguez, Jangsuk Oh, Hsi-En Tsao, Madeline Spetz, Elijah Edmondson, Dana Ashworth, Rui Zheng, Jing Zhou, Jinyun Chen, Jingbao Liu, Guangyan Xiong, Hongbing Zhang, Cheng Liu, Rosa Nguyen, Nan Li, Mitchell Ho   +19 more
doaj   +4 more sources

Chimeric Antigen Receptor engineered gamma delta T cells for neuroblastoma immunotherapy [PDF]

, 2020
Gamma delta (γδ) T cells are a unique subset of lymphocytes that combine both innate and adaptive immune properties. They are primed for rapid function including tumour cell cytotoxicity, and following activation, have professional antigen presenting ...
Capsomidis, Anna
core   +3 more sources

A class of gamma delta T cell receptors recognize the underside of the antigen-presenting molecule MR1

, 2019
T cell receptors (TCRs) recognize antigens presented by major histocompatibility complex (MHC) and MHC class I-like molecules. We describe a diverse population of human gamma delta T cells isolated from peripheral blood and tissues that exhibit autoreactivity to the monomorphic MHC-related protein 1 (MR1). The crystal structure of a gamma delta TCR-MR1-
Le Nours, Jerome, Gherardin, Nicholas A., Ramarathinam, Sri H., Awad, Wael, Wiede, Florian, Gully, Benjamin S., Khandokar, Yogesh, Praveena, T., Wubben, Jacinta M., Sandow, Jarrod J., Webb, Andrew I., von Borstel, Anouk, Rice, Michael T., Redmond, Samuel J., Seneviratna, Rebecca, Sandoval-Romero, Maria L., Li, Shihan, Souter, Michael N. T., Eckle, Sidonia B. G., Corbett, Alexandra J., Reid, Hugh H., Liu, Ligong, Fairlie, David P., Giles, Edward M., Westall, Glen P., Tothill, Richard W., Davey, Martin S., Berry, Richard, Tiganis, Tony, McCluskey, James, Pellicci, Daniel G., Purcell, Anthony W., Uldrich, Adam P., Godfrey, Dale I., Rossjohn, Jamie   +34 more
openaire   +4 more sources

Selection of gamma delta T cells with canonical T-cell antigen receptors in fetal thymus. [PDF]

Proceedings of the National Academy of Sciences, 1990
Two gamma delta T-cell subsets that are generated in the fetal thymus and selectively localize in epidermis and uterus-vagina-tongue epithelia exhibit remarkable homogeneity in their (T-cell) antigen receptors (TCR). In the present study, we show that cells expressing the canonical gamma delta TCR are also generated in fetal thymus organ cultures ...
S, Itohara, S, Tonegawa
openaire   +2 more sources

A Novel Allogeneic Rituximab-Conjugated Gamma Delta T Cell Therapy for the Treatment of Relapsed/Refractory B-Cell Lymphoma

, 2023
Chimeric antigen receptor T cell (CAR-T) therapy has been applied in the treatment of B-cell lymphoma; however, CAR-T manufacturing requires virus- or non-virus-based genetic modification, which causes high manufacturing costs and potential safety ...
Sen-Han Yang, Ciao-Syuan Chen, Yan-Liang Lin, Yun-Jung Chiang, Hao-Kang Li, Yu-Ju Chen, Li-Yu Chen, Ching-Wen Hsiao, Chia-Yun Lee, Zih-Fei Cheng, Hsiu-Ping Yang, Sai-Wen Tang, Shih-Chia Hsiao, Pei-Ju Leng, Yi-Chiu Kuo, Tai-Sheng Wu   +15 more
core   +1 more source

Chimeric Antigen Receptor-Engineered Human Gamma Delta T Cells: Enhanced Cytotoxicity with Retention of Cross Presentation [PDF]

Molecular Therapy, 2018
Gamma delta T (γδT) lymphocytes are primed for rapid function, including cytotoxicity toward cancer cells, and are a component of the immediate stress response. Following activation, they can function as professional antigen-presenting cells. Chimeric antigen receptors (CARs) work by focusing T cell function on defined cell surface tumor antigens and ...
Capsomidis, A, Benthall, G, Van Acker, HH, Fisher, J, Kramer, AM, Abeln, Z, Majani, Y, Gileadi, T, Wallace, R, Gustafsson, K, Flutter, B, Anderson, J   +11 more
openaire   +3 more sources

Human T cell responses to peptides of the Mycobacterium leprae 45-kD serine-rich antigen. [PDF]

, 2002
In order to identify T cell epitopes within the Mycobacterium leprae 45-kD serine-rich antigen, we analysed responses to overlapping 17-mer peptides encompassing the whole antigen in non-exposed UK controls, Pakistani leprosy patients and tuberculosis ...
Zafar, S, Dawood, G, Drijfhout, JW, Smith, S, Lopez, FV, Bothamley, G, Brahmbhatt, S, Hussain, R, Dockrell, HM, Ottenhoff, THM   +9 more
core   +1 more source

Bovine NK cells can produce gamma interferon in response to the secreted mycobacterial proteins ESAT-6 and MPP14 but not in response to MPB70 [PDF]

, 2005
Bovine NK cells have recently been characterized and the present study describes the interaction between NK cells, antigen-presenting cells, and secreted mycobacteriall proteins.
Jungersen, Gregers, Anne K. Storset, Kulberg, Siri, Kulberg, S., Preben Boysen, Boysen, Preben, Jayne C. Hope, Siri Kulberg, Ingrid Olsen, Boysen, P., Storset, Anne K., Olsen, Ingrid, Storset, A.K., Hope, J.C., Gregers Jungersen, Hope, Jayne; id_orcid   +15 more
core   +1 more source

Mixing signals: Molecular turn ons and turn offs for innate γδ Τ cells

Frontiers in Immunology, 2014
Lymphocytes of the gamma delta (γδ) T cell lineage are evolutionary conserved and although they express rearranged antigen-specific receptors a large proportion respond as innate effectors. γδ T cells are poised to combat infection by responding rapidly
Vasileios eBekiaris, Vasileios eBekiaris, John S Šedý, Carl F Ware   +3 more
doaj   +1 more source

Chimeric Antigen Receptor T-Cells for the Treatment of Gamma-Delta T-Cell Malignancies

Blood, 2018
Abstract Introduction Cancers derived from the malignant transformation of gamma delta T-cells are rare but carry very poor prognosis. Hepatosplenic T-cell lymphoma is a highly aggressive condition characterised by hepatosplenic and bone marrow involvement.
Paul Maciocia, Patrycja Wawrzyniecka, Leo Kassimatis, Martin Pule   +3 more
openaire   +1 more source