Results 171 to 180 of about 1,081,363 (314)

From Hurricane Irma to the Grindavík eruptions: volatility premiums in disaster governance. [PDF]

Disasters
Björnsson T.
europepmc   +1 more source

Capital Regulation and Bank Risk Taking: Completing Blum’s Picture [PDF]

This paper studies the intertemporal effects that capital regulation has on curbing bank risk taking, using the seminal model proposed in Blum (1999). Threshold values of the requirement in each period, for which capital regulation start affecting bank ...
Nancy Silva
core  

An Insulin‐Exosome‐TNFAIP8 Axis Drives Stromal Fibrosis and Therapeutic Resistance in Pancreatic Cancer

Advanced Science, EarlyView.
In pancreatic ductal adenocarcinoma (PDAC), insulin is associated with activation of PI3K/AKT–RAB3A signaling and enhanced secretion of TNFAIP8‐enriched exosomes from tumor cells. Uptake of these exosomes by fibroblasts is linked to TRIM21‐dependent STAT1 degradation and the emergence of myofibroblastic CAF–associated features, accompanied by increased
Zhenyu Li, Li Chen, Tao Wang, Haiyang Jiang, Huijuan Wang, Mengyu Li, Guanpeng Xie, Chunhua Xi, Han Yan, Chunhui Lu, Chenchen Li, Hanyu Zhu, Feihu Sun, Lingdi Yin, Jun Yu, Yi Miao   +15 more
wiley   +1 more source

Digital assets: risks, regulations, mitigation. [PDF]

Financ Innov
Teng HW, Härdle WK, Osterrieder J, Pele DT, Baals LJ, Papavassiliou V, Bolesta K, Kabašinskas A, Filipovska O, Thomaidis NS, Moukas AI, Goundar S, Nasir JA, Weinberg AI, Arakelian V, Truică CO, Akar M, Kabaklarlı E, Apostol ES, Iannario M, Bȩdowska-Sójka B, Skaftadóttir HK, Yildirim O, Shala A, Pisoni G, Coita IF, Korba S, Hafner CM, Schwendner P, Molnár B, Xhumari E.   +30 more
europepmc   +1 more source

Bank Capital, Liquidity and Systemic Risk [PDF]

We analyze the impact of capital adequacy regulation on bank insolvency and aggregate investment. We develop a model of the banking system that is characterized by the interaction of many heterogeneous banks with the real sector, interbank credit ...
Eichberger, Jürgen, Summer, Martin
core  

HSP90AB1‐Mediated Ubiquitin‐Proteasome Degradation of ITGBL1 Promotes Osteosarcoma Progression by Inhibiting Endoplasmic Reticulum Stress‐Induced Autophagy

Advanced Science, EarlyView.
This study delineates a novel HSP90AB1‐ITGBL1 signaling axis governing osteosarcoma. HSP90AB1 promotes K63‐linked ubiquitination and proteasomal degradation of ITGBL1. Restoring ITGBL1 induces reactive oxygen species‐dependent endoplasmic reticulum stress and pro‐death autophagy, suppressing tumor growth and metastasis.
Zhen Wang, Zixuan Guo, Chengwei Cao, Ziying Wang, Zifu Huang, Xiujuan Zhang, Yushu Zheng, Diankun She, Hao Zhu, Lingfeng Yu, Xuelin Zhao, Dongquan Xiang, Song Liao, Xin He, Xintong Ji, Chengsheng Wu, Cheng‐Xiong Xu, Meng Xu   +17 more
wiley   +1 more source

Beyond decriminalization: exploring the legalization of abortion globally. [PDF]

Front Reprod Health
Ambast S, Atay H, Lavelanet A.
europepmc   +1 more source

The regulation and supervision of banks around the world - a new database [PDF]

International consultants on bank regulation, and supervision for developing countries, often base their advice on how their home country does things, for lack of information on practice in other countries.
Barth, James R., Caprio Jr, Gerard, Levine, Ross   +2 more
core  

Real‐Time Visualization of Isoform‐Specific RAF‐KRAS Interactions in Living Cells Using FRET‐BRET Hybrid Biosensors

Advanced Science, EarlyView.
Hybrid FRET–BRET biosensors were developed to monitor RAF–KRAS interactions in living cells. These sensors enable real‐time visualization of interaction dynamics, quantitative spectral analysis, and validation of mutation‐selective inhibitors, providing a versatile platform for probing KRAS regulation and therapeutic responses. ABSTRACT The RAS–RAF–MEK–
Jeong‐Min Go, Dahee Lee, Minji Kim, Kiseok Han, Gyuho Choi, ChanHui Song, Sanghyun Ahn, Yerim Lee, Jinyoung Lee, Yingxiao Wang, Jung‐Soo Suh, Hwayoung Yun, Tae‐Jin Kim   +12 more
wiley   +1 more source

Downregulation of dual-specificity phosphatase 1 (DUSP1) in post-mortem brain white matter in progressive multiple sclerosis. [PDF]

Neurol Sci
Oró-Nolla M, Sun MC, Reilly T, Anandarajah J, Otálora-Alcaraz A, Costelloe L, Kearney H, Magee R, Nolan YM, Downer EJ.   +9 more
europepmc   +1 more source