Fatty Acid Synthase Inhibitor G28 Shows Anticancer Activity in EGFR Tyrosine Kinase Inhibitor Resistant Lung Adenocarcinoma Models [PDF]
Cancers, 2020 Epidermal growth factor receptor (EGFR) tyrosine kinases inhibitors (TKIs) are effective therapies for non-small cell lung cancer (NSCLC) patients whose tumors harbor an EGFR activating mutation. However, this treatment is not curative due to primary and secondary resistance such as T790M mutation in exon 20.
Emma Polonio +2 more
exaly +5 more sources
Improving lactose digestion and symptoms of lactose intolerance with a novel galacto-oligosaccharide (RP-G28): a randomized, double-blind clinical trial [PDF]
Nutrition Journal, 2013 Lactose intolerance (LI) is a common medical problem with limited treatment options. The primary symptoms are abdominal pain, diarrhea, bloating, flatulence, and cramping. Limiting dairy foods to reduce symptoms contributes to low calcium intake and the risk for chronic disease.
Dennis A Savaiano, Todd R Klaenhammer
exaly +5 more sources
EGCG-Derivative G28 Shows High Efficacy Inhibiting the Mammosphere-Forming Capacity of Sensitive and Resistant TNBC Models [PDF]
Molecules, 2019 Recent studies showed that Fatty Acid Synthase (FASN), a lipogenic enzyme overexpressed in several carcinomas, plays an important role in drug resistance. Furthermore, the enrichment of Breast Cancer Stem Cell (BCSC) features has been found in breast tumors that progressed after chemotherapy. Hence, we used the triple negative breast cancer (TNBC) cell
Ariadna Giro-Perafita +2 more
exaly +6 more sources
Construction, Expression, and Characterization of BD1-G28-5 sFv, a Single-chain Anti-CD40 Immunotoxin Containing the Ribosome-inactivating Protein Bryodin 1 [PDF]
Journal of Biological Chemistry, 1997 The major limitation to the use of immunotoxins in the clinic is the toxicity associated with the toxin moiety. BD1-G28-5 single-chain Fv (sFv) is a single-chain immunotoxin targeted to human CD40 and consists of bryodin 1 (BD1), a plant ribosome-inactivating protein that is 20-30-fold less toxic in animals than commonly used toxins, fused to the sFv ...
J A, Francisco +2 more
exaly +3 more sources
Characterization of 2S albumin allergenic proteins for anaphylaxis in common buckwheat
Food Chemistry: Molecular Sciences, 2022 2S albumin (2SA) is responsible for anaphylaxis following consumption of buckwheat in allergic individuals. To reduce allergen incidents, characterization of 2SA polypeptides is prerequisite, thus was analyzed in this study. Of the five 2S albumin genes (
Tomoyuki Katsube-Tanaka +1 more
doaj +1 more source
Galacto-Oligosaccharide RP-G28 Improves Multiple Clinical Outcomes in Lactose-Intolerant Patients [PDF]
Nutrients, 2020 Background and Aims: Lactose intolerance (LI) is a global problem affecting more than half of the world’s population. An ultra-purified, high-concentration galacto-oligosaccharide, RP-G28, is being developed as a treatment for patients with LI. The efficacy and safety of RP-G28 in reducing symptoms of lactose intolerance were assessed in a blinded ...
William Chey +5 more
openaire +2 more sources
The Impact of Macroprudential Policy on Credit Growth in Nine Euro Area Economies
Naše Gospodarstvo, 2023 In this paper, we investigate the impact of macroprudential policy measures (bundled together into a macroprudential policy index, MPI) on the non-financial corporate sector credit and household credit growth using a one-step system GMM empirical ...
Lorenčič Eva +2 more
doaj +1 more source
Empirical Analysis of Financial Development and Financial Inclusion Nexus in Nigeria
Studia Ekonomiczne i Regionalne, 2022 Subject and purpose of work: The literature on financial development and economic growth is expansive. The proportion of individuals and firms that use or have access to financial services can be referred to as the financially included.
Anthony-Orji Onyinye I. +3 more
doaj +1 more source
Market Structure Development in a Regulated Market: The Case of the EU Rating Agencies
Business Systems Research, 2021 Background: The motivation for this article is the observation of political and private efforts to establish an EU-based rating agency as a counterweight to the three major agencies and observe other approaches to increase competition in the rating ...
Meeh-Bunse Gunther, Schomaker Stefan
doaj +1 more source
How to Design a Bank Levy: The Effect of a Levy Scheme on Bank Performance and its Activities
Central European Management Journal, 2022 One of the regulatory responses to the 2008 financial crisis was to internalize the costs related to banks’ distress by introducing bank levies. More than 23 European banking sectors have been confronted with the new levy regime imposing the additional ...
Hryckiewicz Aneta, Puławska Karolina
doaj +1 more source