Construction, Expression, and Characterization of BD1-G28-5 sFv, a Single-chain Anti-CD40 Immunotoxin Containing the Ribosome-inactivating Protein Bryodin 1 [PDF]
Journal of Biological Chemistry, 1997 The major limitation to the use of immunotoxins in the clinic is the toxicity associated with the toxin moiety. BD1-G28-5 single-chain Fv (sFv) is a single-chain immunotoxin targeted to human CD40 and consists of bryodin 1 (BD1), a plant ribosome-inactivating protein that is 20-30-fold less toxic in animals than commonly used toxins, fused to the sFv ...
C B Siegall, Clay B Siegall
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EGCG-Derivative G28 Shows High Efficacy Inhibiting the Mammosphere-Forming Capacity of Sensitive and Resistant TNBC Models [PDF]
Molecules, 2019 Recent studies showed that Fatty Acid Synthase (FASN), a lipogenic enzyme overexpressed in several carcinomas, plays an important role in drug resistance. Furthermore, the enrichment of Breast Cancer Stem Cell (BCSC) features has been found in breast tumors that progressed after chemotherapy. Hence, we used the triple negative breast cancer (TNBC) cell
Lidia Feliu +2 more
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Galacto-Oligosaccharide RP-G28 Improves Multiple Clinical Outcomes in Lactose-Intolerant Patients [PDF]
Nutrients, 2020 Background and Aims: Lactose intolerance (LI) is a global problem affecting more than half of the world’s population. An ultra-purified, high-concentration galacto-oligosaccharide, RP-G28, is being developed as a treatment for patients with LI. The efficacy and safety of RP-G28 in reducing symptoms of lactose intolerance were assessed in a blinded ...
William D. Chey +5 more
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G28 Effective safety netting: an important contribution to avoiding preventable deaths [PDF]
Archives of Disease in Childhood, 2015 Safety netting has conventionally been used during consultations when clinicians are uncertain about the trajectory of an illness to provide patients with guidance about when and where to re-consult (Roland et al 2013). Recent high profile events involving failure to recognise and appropriately safety net children with sepsis highlights this is a ...
SJ Neill +4 more
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Fatty Acid Synthase Inhibitor G28 Shows Anticancer Activity in EGFR Tyrosine Kinase Inhibitor Resistant Lung Adenocarcinoma Models [PDF]
Cancers, 2020 Epidermal growth factor receptor (EGFR) tyrosine kinases inhibitors (TKIs) are effective therapies for non-small cell lung cancer (NSCLC) patients whose tumors harbor an EGFR activating mutation. However, this treatment is not curative due to primary and secondary resistance such as T790M mutation in exon 20.
Emma Polonio‐Alcalá +8 more
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G28(P) How can we improve induction to the paediatric and neonatal intensive care units? [PDF]
British Association for Paediatric Nephrology and Paediatric Intensive Care Society, 2018 Background Our regional Paediatric and Neonatal Intensive Care Units (PICU and NICU) care for 1700 critically unwell children a year. Medical staffing is provided by senior paediatric or anaesthetic trainees, and overseas fellows from diverse professional backgrounds, starting at several different points throughout the year, completing rotations of 3 ...
M Emedo
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G28 A Novel Missense Mutation in Keratin 1 Underlying Clinically Mild Epidermolytic Ichthyosis Mimicking Epidermolysis Bullosa Simplex Superficialis [PDF]
Archives of Disease in Childhood, 2013 Inherited skin peeling may be autosomal recessive (AR) or autosomal dominant (AD). When AR, this can be localised, as in acral peeling skin syndrome (APSS); or generalised, as in peeling skin syndrome (PSS) types A (non-inflammatory) and B (inflammatory).
A. Mackenzie +8 more
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Improving lactose digestion and symptoms of lactose intolerance with a novel galacto-oligosaccharide (RP-G28): a randomized, double-blind clinical trial [PDF]
Nutrition Journal, 2013 Lactose intolerance (LI) is a common medical problem with limited treatment options. The primary symptoms are abdominal pain, diarrhea, bloating, flatulence, and cramping. Limiting dairy foods to reduce symptoms contributes to low calcium intake and the risk for chronic disease.
Dennis A. Savaiano +7 more
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On the formation fo caldera-like features on Ganymede: implicatoins from Galileo-G28 images [PDF]
, 2017 Topographic data are used to find implications for the formation of Caldera-like Features on Ganymede.
B. Giese, Ernst Hauber, Hauke Hußmann
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The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements. They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
Minor Planet Center Staff
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