Results 11 to 20 of about 8,393 (257)

EGCG-Derivative G28 Shows High Efficacy Inhibiting the Mammosphere-Forming Capacity of Sensitive and Resistant TNBC Models [PDF]

Molecules, 2019
Recent studies showed that Fatty Acid Synthase (FASN), a lipogenic enzyme overexpressed in several carcinomas, plays an important role in drug resistance.
Ariadna Giró-Perafita, Marc Rabionet, Marta Planas   +2 more
exaly   +8 more sources

Galacto-Oligosaccharide RP-G28 Improves Multiple Clinical Outcomes in Lactose-Intolerant Patients [PDF]

Nutrients, 2020
Background and Aims: Lactose intolerance (LI) is a global problem affecting more than half of the world’s population. An ultra-purified, high-concentration galacto-oligosaccharide, RP-G28, is being developed as a treatment for patients with LI. The
William Chey, Dennis A. Savaiano, M. Andrea Azcarate-Peril, William Sandborn, Howard Foyt, Andrew J. Ritter   +5 more
core   +4 more sources

Fatty Acid Synthase Inhibitor G28 Shows Anticancer Activity in EGFR Tyrosine Kinase Inhibitor Resistant Lung Adenocarcinoma Models [PDF]

Cancers, 2020
Epidermal growth factor receptor (EGFR) tyrosine kinases inhibitors (TKIs) are effectivetherapies for non-small cell lung cancer (NSCLC) patients whose tumors harbor an EGFR activatingmutation.
Feliu, Lidia, Lidia Feliu, Sònia Palomeras, Puig i Miquel, Teresa, Polonio Alcalá, Emma, Ciurana, Joaquim, Emma Polonio-Alcalá, Torres Oteros, Daniel, Ruiz-Martínez, Santiago, Marta Planas, Planas i Grabuleda, Marta, Planas, Marta, Teresa Puig, Santiago Ruiz-Martínez, Palomeras Pairet, Sònia, Polonio-Alcalá, Emma, Relat, Joana, Feliu Soley, Lidia, Palomeras, Sonia, Ruiz Martínez, Santiago, Daniel Torres-Oteros, Joana Relat, Ciurana, Quim de, Joaquim Ciurana, Relat Pardo, Joana, Torres-Oteros, Daniel   +25 more
core   +7 more sources

CHI3L1-targeted small molecules as glioblastoma therapies: Virtual screening-based discovery, biophysical validation, pharmacokinetic profiling, and evaluation in glioblastoma spheroids. [PDF]

Eur J Med Chem
Glioblastoma (GBM) remains the most aggressive primary brain malignancy with a 10 % three-year survival rate. Chitinase-3-like protein 1 (CHI3L1) has emerged as a critical factor in the progression of GBM progression, invasion, and treatment resistance ...
Nada H, Zhang L, Kaur B, Gabr MT.
europepmc   +4 more sources

Improving Lactose Digestion and Symptoms of Lactose inTolerance with a Novel Galacto-Oligosaccharide (RP-G28): a Randomized, Double-Blind Clinical Trial. [PDF]

Nutrition Journal, 2013
Background Lactose intolerance (LI) is a common medical problem with limited treatment options. The primary symptoms are abdominal pain, diarrhea, bloating, flatulence, and cramping.
Gareth M James, Walker, W Allan, Savaiano, Dennis, Ritter, Andrew J, Klaenhammer, Todd R, Andrew J Ritter, Justin R Chandler, Longcore, Amy T, Dennis A Savaiano, Todd R Klaenhammer, Amy T Longcore, Foyt, Howard L, W Allan Walker, James, Gareth M, Howard L Foyt, Chandler, Justin R   +15 more
core   +5 more sources

Characterization of 2S albumin allergenic proteins for anaphylaxis in common buckwheat [PDF]

Food Chemistry: Molecular Sciences, 2022
2S albumin (2SA) is responsible for anaphylaxis following consumption of buckwheat in allergic individuals. To reduce allergen incidents, characterization of 2SA polypeptides is prerequisite, thus was analyzed in this study. Of the five 2S albumin genes (
Tomoyuki Katsube-Tanaka, Fakhrul Islam Monshi   +1 more
doaj   +2 more sources

G28 Effective safety netting: an important contribution to avoiding preventable deaths [PDF]

Archives of Disease in Childhood, 2015
Safety netting has conventionally been used during consultations when clinicians are uncertain about the trajectory of an illness to provide patients with guidance about when and where to re-consult (Roland et al 2013). Recent high profile events involving failure to recognise and appropriately safety net children with sepsis highlights this is a ...
S. Neill, C. Jones, D. Roland, Matthew J. Thompson, M. Lakhanpaul   +4 more
semanticscholar   +2 more sources

(−)-Epigallocatechin 3-Gallate Synthetic Analogues Inhibit Fatty Acid Synthase and Show Anticancer Activity in Triple Negative Breast Cancer [PDF]

Molecules, 2018
(−)-Epigallocatechin 3-gallate (EGCG) is a natural polyphenol from green tea with reported anticancer activity and capacity to inhibit the lipogenic enzyme fatty acid synthase (FASN), which is overexpressed in several human carcinomas.
Joan Crous-Masó, Sònia Palomeras, Joana Relat, Cristina Camó, Úrsula Martínez-Garza, Marta Planas, Lidia Feliu, Teresa Puig   +7 more
doaj   +3 more sources

Gynaecology Teaching Associates in Medical Education-A Scoping Review. [PDF]

Clin Teach
ABSTRACT Background Pelvic examination is a core, yet anxiety‐provoking, clinical skill in undergraduate medical education. Traditional teaching approaches—often opportunistic or reliant on simulation—have been criticised for disembodying technical skill from relational and ethical practice. Gynaecology Teaching Associates (GTAs), trained educators who
Kelly C, Bell E, Brown MEL, Stelling H.
europepmc   +2 more sources

Ganymede: very high resolution data from G28 reveal new perspectives on processes and history

, 2001
Recent G28 very high resolution image data provides new insight into five major problem areas and shows evidence for strike-slip faulting and processes perhaps like Europa band ...
Wagner, R., Neukum, G., Nixon, B., Collins, G.C. (Dept. Geol. Sci., Brown Univ., Providence, RI, USA),, Spaun, N.A., Pappalardo. R.,, Giese, B., Head, J.W.   +7 more
core   +2 more sources