Results 241 to 250 of about 223,337 (312)

Downregulation of dual-specificity phosphatase 1 (DUSP1) in post-mortem brain white matter in progressive multiple sclerosis. [PDF]

Neurol Sci
Oró-Nolla M, Sun MC, Reilly T, Anandarajah J, Otálora-Alcaraz A, Costelloe L, Kearney H, Magee R, Nolan YM, Downer EJ.   +9 more
europepmc   +1 more source

Conformational Snapshots of CydDC in a Native Lipid Bilayer Coupling Heme Transport to Antibiotic Resistance

Advanced Science, EarlyView.
Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang, Changbin Zhang, Mengyuan Lyu, Yongbo Luo, Jierou Zhang, Yujiao Chen, Lintao Luo, Wen Qiao, Xiangyangpeng Li, Yu Zhou, Zhongling Wei, Yuling Xiao, Qian Niu, Juan Zhou, Guanglin He, Binwu Ying, Zhaoming Su, Hao Chen, Xiaodi Tang, Haohao Dong   +19 more
wiley   +1 more source

Identification of Alzheimer's disease subtypes and biomarkers from human multi-omics data using subspace merging algorithm. [PDF]

Alzheimers Dement
Song Z, Huang X, Jannu AJ, Johnson TS, Zhang J, Huang K.   +5 more
europepmc   +1 more source

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, EarlyView.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

Advanced Science, EarlyView.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu, Zhihao Zhan, Xiaoxiang Pan, Xinyue Zhang, Penggang Liu, Jing Sun, Xiulong Xu   +6 more
wiley   +1 more source

Manufacture of Clostridioides difficile Spores for Experimental Infection of Human Volunteers. [PDF]

J Infect Dis
Hensen ADO, Harmanus C, Voorvelt C, Geelen AR, El Hamdioui M, Kuijper EJ, Pattacini L, Schipper P, van Amerongen-Westra IM, Meij P, van der Stoep MYEC, Roestenberg M, Smits WK.   +12 more
europepmc   +1 more source

Game analysis of green finance assisting enterprises in carbon reduction under the participation of four parties. [PDF]

Front Public Health
Wang J, Liu X, Duan H, Wang L.
europepmc   +1 more source

CTCF Regulates Erythroid Differentiation Through Control of Core Erythroid Transcription Factors. [PDF]

Biomolecules
García-Gaipo L, Junco V, García-Gutiérrez L, Torrano V, Blanco R, Wiesinger A, Pradeep R, Arroyo JL, Batlle-López A, León J, Rosa-Garrido M, Delgado MD.   +11 more
europepmc   +1 more source