Results 41 to 50 of about 1,081,363 (314)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Size matters: analyzing bank profitability and efficiency under the Basel III framework
Financial Innovation, 2023 The latest regulatory framework, which has been introduced globally in the form of Basel III, and its implementation in the legislation of the member states of the European Union has generated much interest in the impact of regulation on the efficiency ...
Ivan Gržeta +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Bank Guarantee: Significance and Regulation Issues of the solvet et repete Principle
Socialiniai Tyrimai, 2020 Global economic crises, pandemic outbreaks have negative impacts not only on national economic indicators but also on the global economy, forcing businesses to suspend their activities or even close down.
Giedrius Nemeikšis
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
, 1999 This paper presents a model consistent with the business cycle view of the origins of banking panics. As in Allen and Gale [1], bank runs arise endogenously as a consequence of the standard deposit contract in a world with aggregate uncertainty about ...
Samartín Sáenz, Margarita
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Business Cycle and Bank Capital Regulation: Basel II Procyclicality [PDF]
This paper studies the impact of bank capital regulation on business cycle fluctuations. In particular, we study the procyclical nature of Basel II claimed in the literature. To do so, we adopt the Bernanke et al.
Guangling (Dave) Liu, Nkhahle Seeiso
core +3 more sources
Padjadjaran: Jurnal Ilmu Hukum, 2015 ABSTRAK Masyarakat Ekonomi ASEAN akan dimulai akhir tahun 2015 ini. Pada pelaksanaan MEA, kompetisi perbankan Indonesia dengan negara-negara lain dalam merebut investor tidak dapat dihindari lagi.
Tarsisius Murwaji
doaj +1 more source