Results 41 to 50 of about 9,439,985 (300)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Social Sciences and Humanities OpenThis study contributes to the growing literature on the 8th Sustainable Development Goals by estimating the impacts of the Consumer Price Index, transportation infrastructure, and unemployment on capital stock in Chinese provinces.
Hoa Kim Thi Vu +3 more
doaj +1 more source
A Tale of Two Supervisors: Compliance with Risk Disclosure Regulation in the Banking Sector [PDF]
, 2021 We examine how the presence of multiple supervisory agencies affects firm-level compliance in form and substance with disclosure regulations. This analysis is important because coordination problems among regulators are frequently present in practice but
Jannis Bischof +7 more
core +2 more sources
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
A scalable tool for farm-level carbon accounting: evidence from UK agriculture
Environmental Research LettersAccurately quantifying greenhouse gas (GHG) emissions at the farm level is crucial for agricultural decarbonisation, yet doing so remains challenging—particularly for smaller farming operations that lack resources for comprehensive data collection.
Jasmine Wells +6 more
doaj +1 more source
Can pump-and-dump manipulation and SEO market timing boost zombie firms back to normal?
Borsa Istanbul ReviewWhile prior studies have examined the accessibility of bank credit and government incentives for zombie firms, this paper addresses an important gap by investigating the relationship between pump-and-dump stock price manipulation and the timing of ...
Duong Dang Khoa +3 more
doaj +1 more source
Antea Group Archeologie 2020/159
, 2021 In augustus 2020 – maart 2021 heeft Antea Group een archeologisch bureauonderzoek en inventariserend veldonderzoek uitgevoerd ter voorbereiding op het verleggen van een DN400 drinkwaterleiding in Ewijk, gemeente Beuningen.
Fens, R.L. (Antea Group) +1 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
State of Connecticut Department of Banking
, 2008 Updated irregularly; Began in 2002?; Title from home page (publisher's Web site, viewed Nov. 19, 2010).; At head of title: State of Connecticut.; Harvested from the web on 1/5/11Official website of the Connecticut Department of Banking.
core +1 more source