Results 41 to 50 of about 2,272,414 (343)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Cysteines and Disulfide-Bridged Macrocyclic Mimics of Teixobactin Analogues and Their Antibacterial Activity Evaluation against Methicillin-Resistant Staphylococcus Aureus (MRSA)

Pharmaceutics, 2018
Teixobactin is a highly potent cyclic depsipeptide which kills a broad range of multi-drug resistant, Gram-positive bacteria, such as Methicillin-resistant Staphylococcus aureus (MRSA) without detectable resistance.
Ruba Malkawi, Abhishek Iyer, Anish Parmar, Daniel G. Lloyd, Eunice Tze Leng Goh, Edward J. Taylor, Sarir Sarmad, Annemieke Madder, Rajamani Lakshminarayanan, Ishwar Singh   +9 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

On Estimating Differential Conductance from Noisy I-V Measurements in Delineating Device Parameters [PDF]

Acta Electrotechnica et Informatica, 2017
Differential conductance is a key to characterizing a solid-state device. Estimation of differential conductance from current-voltage characteristic curve amounts to estimate the first order derivative from a discrete set of current-voltage measurements ...
Indrajit G. ROY
doaj   +1 more source

Fire Watcher by Vivian Demuth [PDF]

, 2014
Review of Fire Watcher by Vivian ...
Banks, Anna
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Galleria mellonella Infection Model Identifies Both High and Low Lethality of Clostridium perfringens Toxigenic Strains and Their Response to Antimicrobials

Frontiers in Microbiology, 2019
Research progress into mechanisms of the anaerobe Clostridium perfringens and associated diseases has been frustrated by the lack of reliable infection models.
Sammy Kay, Sammy Kay, Joseph Edwards, Joseph Edwards, Joseph Brown, Ronald Dixon   +5 more
doaj   +1 more source

Lectures on Holographic Space Time [PDF]

, 2013
Summary of three talks on the Holographic Space Time models of early universe cosmology, particle physics, and the asymptotically de Sitter final state of our universe.Comment: LaTex2e.
Banks, T.
core  

Regulating hate speech online [PDF]

, 2010
The exponential growth in the Internet as a means of communication has been emulated by an increase in far-right and extremist web sites and hate based activity in cyberspace.
Banks, James
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source