Results 61 to 70 of about 2,272,414 (343)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

High prevalence of multi-drug-resistant bacteria in faecal samples from UK passerine birds

Scientific Reports
Wild birds are a near ubiquitous sight in gardens, offering pleasure to many people through supplementary feeding, song, or other interactions. However, they are also potential carriers of many bacteria, including Campylobacter spp., Salmonella spp ...
Jenny C. Dunn, Simon R. Clegg
doaj   +1 more source

INSURANCE MARKET DEVELOPMENT BEFORE AND AFTER THE FINANCIAL CRISIS IN THE CONTEXT OF ETHICS AND CORRUPTION [PDF]

Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2017
The financial crisis can generate instability in any field. High levels of perceived corruption, unethical behavior or high unemployment rate can be several relevant examples that can influence well-being.
GABRIEL ARMEAN , GABRIELA-MIHAELA MUREŞAN   +1 more
doaj  

Age, condition and dominance‐related sexual ornament size before and during the breeding season in the black grouse Lyrurus tetrix

Journal of Avian Biology, 2018
Male ornaments function as honest cues of male quality in many species and are subject to intra‐ and intersexual selection. These ornaments are generally studied during peak expression, however their size outside the breeding season may determine ...
Sarah Harris, Matti Kervinen, Christophe Lebigre, Thomas W. Pike, Carl D. Soulsbury   +4 more
doaj   +1 more source

Good Banks and bad Banks, centralised Banks and local Banks and economic Growth

Ekonomiaz. Revista vasca de Economía, 2013
The on-going banking crisis has demonstrated the significance of banking for economic growth. While banks as creators of money are important for the functioning of the economy, bank lending to productive enterprises is necessary for economic activity.
Chick, Victoria, Dow, Sheila, Rodriguez-Fuentes, Carlos J   +2 more
openaire   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Dirac Gluinos in the Pyramid Scheme [PDF]

, 2013
I point out several terms in the low energy effective Lagrangian of the Pyramid Scheme, which were missed in a previous analysis of the phenomenological consequences of the model. They lead to a Dirac contribution to the gluino mass, much larger than the
Banks, T.
core  

Banking Across Borders With Heterogeneous Banks [PDF]

International Finance Discussion Papers, 2013
This paper develops a model of banking across borders where banks differ in their efficiencies that can replicate key patterns in the data. More efficient banks are more likely to have assets, liabilities and affiliates abroad and have larger foreign operations.
openaire   +3 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Dimensions of the company’s efficiency

Annals of Spiru Haret University Economic Series, 2010
The synthetic concept of business activity assessment, effectiveness circumscribe their theoretical and practical, a multi-dimensional configuration, which gives supportive and evaluative irrelevant in the field of business.
Gheorghe MANOLESCU, Marinela GEAMĂNU
doaj