Results 81 to 90 of about 3,026,344 (368)
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
, 2016 We examine the relation between banks’ corporate social responsibility (CSR) and financial performance in a context of the recent financial crisis.
M. M. Cornett +2 more
semanticscholar +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Aggregate liquidity shortages, idiosyncracic liquidity smoothing and banking regulation [PDF]
, 2005 This paper develops a model of banking fragility driven by aggregate liquidity shortages. Inefficiencies arise because liquidity smoothing across banks breaks down when there is such a shortage, causing unnecessary and value-reducing transfer of assets ...
Wagner, Wolf
core
INSURANCE MARKET DEVELOPMENT BEFORE AND AFTER THE FINANCIAL CRISIS IN THE CONTEXT OF ETHICS AND CORRUPTION [PDF]
Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2017 The financial crisis can generate instability in any field. High levels of perceived corruption, unethical behavior or high unemployment rate can be several relevant examples that can influence well-being.
GABRIEL ARMEAN +1 more
doaj
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source
Molecular Oncology, EarlyView.TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach +8 more
wiley +1 more source
Merging: Contemplations on Farming & Ecology from Horseback by Soren Bondrup-Nielsen [PDF]
, 2015 Anna Banks reviews Merging: Contemplations on Farming & Ecology from Horseback, by Soren Bondrup ...
Banks, Anna
core +1 more source
Animal WelfareParrots (Psittaciformes) are widely kept in captivity, yet their welfare is under-researched in comparison to other captive species. This study aimed to determine key welfare issues affecting parrots through a modified Delphi approach.
Rhianne Chalmers +2 more
doaj +1 more source
Journal of Avian Biology, 2018 Male ornaments function as honest cues of male quality in many species and are subject to intra‐ and intersexual selection. These ornaments are generally studied during peak expression, however their size outside the breeding season may determine ...
Sarah Harris +4 more
doaj +1 more source