Results 251 to 260 of about 60,539 (315)

Hospital‐Based Cross‐Sectional Study of Burkholderia pseudomallei Seroreactivity Among Febrile Patients in Northernmost Vietnam: Near‐Neighbor Bloodstream Isolates, Environmental Correlates, and Spatial Clustering

open access: yesGeoHealth, Volume 10, Issue 6, June 2026.
Abstract Melioidosis is a potentially fatal tropical disease caused by the environmentally mediated bacterium, Burkholderia pseudomallei. In Vietnam, melioidosis is not nationally reportable and little is known regarding its epidemiology and distribution in the northernmost mountainous provinces.
Morgan C. Metrailer   +14 more
wiley   +1 more source

Determining the Character of Subglacial Sediments in the Ice‐Bedrock Interface Zone of Antarctica Using Horizontal‐to‐Vertical Spectral Ratios (HVSRs) of Seismic Ambient Noise

open access: yesJournal of Geophysical Research: Solid Earth, Volume 131, Issue 6, June 2026.
Abstract Interactions between the Antarctic Ice Sheet and the underlying solid Earth occur within the ice‐bedrock interface zone (IBIZ), containing structures of sediments and rocks that strongly influence ice sheet dynamics. Existing insights into the Antarctic IBIZ come primarily from interpretations of airborne geophysical data and active seismic ...
I. D. Kelly   +10 more
wiley   +1 more source

Design, Synthesis of Novel Quinazolinone Derivatives and Evaluation of EGFR Kinase Inhibition Activity via In Vitro and In Silico Studies

open access: yesChemical Biology &Drug Design, Volume 107, Issue 6, June 2026.
Seventeen new quinazolinone derivatives were synthesized in pure form. Compound 4j showed the highest inhibitory activity against the A549 cell line and induced apoptosis via caspase‐3 activation in MCF‐7 cells. 4j inhibited EGFR enzyme twice as effectively as gefitinib.
Aybüke Züleyha Kaya   +3 more
wiley   +1 more source

Biological and In Silico Evaluation of Novel Methoxyphenol–1,2,3‐Triazole Hybrids as Multifunctional Anti‐Alzheimer's and Anticancer Agents

open access: yesChemical Biology &Drug Design, Volume 107, Issue 6, June 2026.
Novel methoxyphenol‐1,2,3‐triazole hybrids were synthesized as multifunctional leads. Compound 5e exhibited potent PC3 cytotoxicity (IC50: 3.57 μM), while 5c showed superior AChE inhibition (IC50: 1.44 μM) and high selectivity (SI: 6.22). DFT and docking studies confirmed their dual‐targeting potential, providing a robust scaffold for Alzheimer's and ...
Sultan Onur   +2 more
wiley   +1 more source

Predictors of Exercise Performance in Type 1 Diabetes: The Role of Hypoglycaemia Fear, Glycaemic Control, and Vascular Health: A Retrospective Cross‐Sectional Study

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 6, Page 5229-5239, June 2026.
ABSTRACT Aim Cardiorespiratory fitness is often impaired in individuals with type 1 diabetes. While physiological determinants have been studied, psychological barriers such as fear of hypoglycaemia remain underexplored. We hypothesised that glycaemic factors including HbA1c, diabetes duration, the presence of microvascular complications, and fear of ...
Arne Kooistra   +6 more
wiley   +1 more source

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