Results 91 to 100 of about 1,714,511 (281)
BMC GastroenterologyBackground Autoimmune liver diseases (AILDs) are associated with systemic rheumatic diseases (SRDs) and their autoantibodies. This study investigates the prevalence of SRDs and related autoantibodies in AILD patients and their prognostic implications ...
Mohammad Egbaria +3 more
doaj +1 more source
A New Method of Geological Modeling for the Hydrocarbon Secondary Migration Research
Applied SciencesReservoir geological modeling plays a crucial role in characterizing the spatial distribution and heterogeneity of subsurface reservoirs. The exploration of deep oil and gas resources is not only a global trend in the oil industry but also an inevitable ...
Yong Zhang +6 more
doaj +1 more source
Unital operads, monoids, monads, and bar constructions
Advances in MathematicsWe give a description of unital operads in a symmetric monoidal category as monoids in a monoidal category of unital $Λ$-sequences. This is a new variant of Kelly's old description of operads as monoids in the monoidal category of symmetric sequences.
May, J. P., Zhang, Ruoqi, Zou, Foling
openaire +2 more sources
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
International Journal of General Medicine, 2022 Tao He,1,* Gang Li,2,* Shoujia Xu,1 Leyun Guo,1 Bing Tang1 1Department of Orthopedics, Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan, Hubei, 442008, People’s Republic of China; 2Department of Sports Medicine, Sinopharm
He T, Li G, Xu S, Guo L, Tang B
doaj
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source