Results 81 to 90 of about 1,714,511 (281)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Modeling and Calculation of Power Consumption of Sahand 68s Combine for Harvesting Wheat (Alvand Variety) [PDF]
Journal of Agricultural Science and Sustainable Production, 2010 Energy is an important input in agriculture and harvesting operation of grain crops constitutes a major part of total energy input. Hence, calculation of power consumption for this operation to minimize power loss is essential.
SH Abdollahpour +2 more
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Teshugang, 2013 In view of the problem of insufficient capacity of cooling bed with increasing output of rolling mill products, the through-water cooling unit for rolled bar is installed. Production results show that for HRB335 Φ16 mm hot-rolled ribbed steel bar (/%: 0.
焦国利, 刘霞, 何文萍
doaj
Utilizing Hybrid RO-OARO Systems as New Methods for Desalination Process
Iraqi Journal of Chemical and Petroleum EngineeringThe scarcity of fresh water and its essential role in sustaining life on Earth have motivated researchers to seek new, low-cost, scalable technologies for water desalination.
Hassanain A. Hassan +2 more
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
THE LABELLING OF THE CONTAINERS FOR STORAGE AND TRANSPORTATION OF MEDICINAL PRODUCTS
Безопасность и риск фармакотерапии, 2018 15-25% of cases of the medicatiom errors caused by the similarity in spelling or pronunciation of their names. The labelling may be a means of protection against such errors.
A. P. Pereverzev, B. K. Romanov
doaj
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source