Results 11 to 20 of about 6,005 (131)

The V-Shaped Hamilton Receptors: A Paradigmatic Multipurpose Scaffold. [PDF]

ChemistryOpen
This manuscript explores the historical context and significance of molecular recognition in relation to Hamilton‐type receptors. It concludes with a discussion on future prospects for the development of novel functionalized Hamilton‐type receptors. It is hoped that this collection will offer new insights and directions for the supramolecular chemistry
Ahmad Wagay S, Ali R.
europepmc   +2 more sources

The fc fragment of IgMs binds C1q to activate the first step of the classical complement pathway, while inhibiting complement-dependent cytotoxicity. [PDF]

FEBS J
Multimeric IgM‐fragment crystallizable region (Fc) fragments retain the ability to bind C1q and initiate the classical complement pathway, leading to C4 activation and deposition in vitro. However, the Fc cores can also inhibit complement‐dependent cytotoxicity by competing with surface‐bound antibodies for C1q engagement.
Pinto AJ, Chouquet A, Bally I, Rossi V, Thielens NM, Dumestre-Pérard C, Kunert R, Gaboriaud C, Ling WL, Reiser JB.   +9 more
europepmc   +2 more sources

Analysis of Illicit Street Heroin Seized in Pakistan by Gas Chromatography-Mass Spectrometry (GC-MS) for Identification of Adulterants and Impurities. [PDF]

Int J Anal Chem
Heroin abuse poses a significant public health and law enforcement challenge globally, with concerns in Pakistan due to the prevalence of illicit street heroin and limited data on its composition. This study analyzed 706 heroin samples seized between 2017 and 2022 using gas chromatography–mass spectrometry (GC‐MS) and Fourier transform infrared ...
Usman M, Baig Y, Naseer A, Nardiello D, Quinto M.   +4 more
europepmc   +2 more sources

Analysis of Reactive Oxygen Species-Induced Cellular Damage in Cervical Cancer. [PDF]

Curr Protoc
Abstract Reactive oxygen species (ROS) are highly reactive oxygen‐based molecules comprising hydrogen peroxide, hydroxyl radicals, superoxide anion, and singlet oxygen. These species are produced intracellularly and play an important role in cellular signaling and metabolism. Their high reactivity damages intracellular macromolecules such as lipids and
Chan HCC, Bhoora S, Zhou E, Marais S, Punchoo R.   +4 more
europepmc   +2 more sources

The Genotypic and Phenotypic Spectrum of GOSR2 Mutations: Clinical and Pathophysiological Insights. [PDF]

J Inherit Metab Dis
ABSTRACT North Sea‐Progressive Myoclonus Epilepsy (NS‐PME) is a progressive neurological disorder, initially only associated with the homozygous GOSR2 founder mutation (c.430G>T; p.Gly144Trp). Clinical symptoms include untreatable early‐onset ataxia, cortical myoclonus and epilepsy.
Polet SS, Siegal EZ, Fuchs SA, Tijssen MAJ, de Koning TJ.   +4 more
europepmc   +2 more sources

In Vitro Calcification of Bioprosthetic Heart Valves: Method Validation by Comparative Heart Valve Calcification Testing. [PDF]

Artif Organs
We have developed a unique method for pre‐clinical heart valve prostheses evaluation of calcification propensity. Results from the test can directly be translated into improvements of prostheses design, materials, and anti‐calcification treatments, and therefore have a significant impact on heart valve prostheses quality and patient care in the future.
Kiesendahl N, Schmitz C, Peters L, Weiler M, Schmitz-Rode T, Steinseifer U, Clauser JC.   +6 more
europepmc   +2 more sources

The Study of Improvement in Sleep Function with Compounded Formulations of Ziziphus jujuba Extract, Longan Lour Extract, γ-Amino Butyric Acid, and Casein Hydrolysate

Shipin gongye ke-ji, 2023
In this paper, through the direct sleep experiment, the experiment of prolonging the sleep time of pentobarbital sodium, the hypnosis experiment of subthreshold dose of pentobarbital sodium and the sleep latency experiment of pentobarbital sodium, the ...
Yujing YAO, Shumin ZHANG, Yanyan REN, Zhao YANG, Jiajia HUANG   +4 more
doaj   +1 more source

Anomalous Solubility Behavior of Several Acidic Drugs

ADMET and DMPK, 2014
The “anomalous solubility behavior at higher pH values” of several acidic drugs originally studied by Higuchi et al. in 1953 [1], but hitherto not fully rationalized, has been re-analyzed using a novel solubility-pH analysis computer program, pDISOL-XTM.
Alex Avdeef
doaj   +1 more source

General anesthetic binding mode via hydration with weak affinity and molecular discrimination: General anesthetic dissolution in interfacial water of the common binding site of GABAA receptor

Biophysics and Physicobiology, 2023
The GABAA receptor (GABAAR) is a target channel for the loss of awareness of general anesthesia. General anesthetic (GA) spans a wide range of chemical structures, such as monatomic molecules, barbital acids, phenols, ethers, and alkanes.
Tomoyoshi Seto
doaj   +1 more source

The Key Role of GSH in Keeping the Redox Balance in Mammalian Cells: Mechanisms and Significance of GSH in Detoxification via Formation of Conjugates

Antioxidants, 2023
Glutathione (GSH) is a ubiquitous tripeptide that is biosynthesized in situ at high concentrations (1–5 mM) and involved in the regulation of cellular homeostasis via multiple mechanisms.
Sofia K. Georgiou-Siafis, Asterios S. Tsiftsoglou   +1 more
doaj   +1 more source