Results 1 to 10 of about 61,678 (252)

Systematic review and meta-analysis of propofol versus barbiturates for controlling refractory status epilepticus

open access: yesBMC Neurology, 2019
Background Several studies have compared the efficacy and safety of propofol and barbiturates in the treatment of refractory status epilepticus (RSE). This study aims to quantitatively assess the advantages and disadvantages of propofol and barbiturates ...
Qing Zhang, Yun Yu, Yu Lu, Hongli Yue
doaj   +2 more sources

Antibacterial, Antiurease, and Antioxidant Activities of Some Arylidene Barbiturates

open access: yesApplied Biochemistry and Biotechnology, 2013
Some series of arylidene barbiturates and thiobarbiturates were evaluated for their antibacterial, antioxidant, and urease inhibition activities. The arylidene barbiturates and thiobarbiturates were tested for antimicrobial activity using the agar well ...
Refiye Yanardag
exaly   +2 more sources

Amphipathic Barbiturates as Mimics of Antimicrobial Peptides and the Marine Natural Products Eusynstyelamides with Activity against Multi-resistant Clinical Isolates.

open access: yesJournal of Medicinal Chemistry, 2021
We report a series of synthetic cationic amphipathic barbiturates inspired by the pharmacophore model of small antimicrobial peptides (AMPs) and the marine antimicrobials eusynstyelamides.
M. Paulsen   +12 more
semanticscholar   +1 more source

Early use of barbiturates is associated with increased mortality in traumatic brain injury patients from a propensity score-based analysis of a prospective cohort.

open access: yesPLoS ONE, 2022
Barbiturates are proposed as a second/third line treatment for intracranial hypertension in traumatic brain injury (TBI) patients, but the literature remains uncertain regarding their benefit/risk balance.
Maxime Léger   +11 more
doaj   +1 more source

Topiramate and other kainate receptor antagonists for depression: A systematic review of randomized controlled trials

open access: yesNeuropsychopharmacology Reports, 2022
Background Depression is a common disorder that affects patients' quality of life and incurs health system costs. Due to the resistance to treat depression, better understanding of neurophysiology was considered; one of the implications is the ...
Ahmad Shamabadi
doaj   +1 more source

Narcotics Addiction and Its Treatment [PDF]

open access: yes, 1957
The ongoing mythologizing of the poet in both criticism and, as recently in a play produced by Wasa teater (Vasa), is reductive, and needs to be confronted.
Winick, Charles
core   +4 more sources

Barbiturates and pyrazolopyridines for the treatment of postpartum depression—repurposing of two drug classes

open access: yesFrontiers in Pharmacology, 2023
Zulresso (brexanolone) is an aqueous formulation of the neurosteroid, allopregnanolone, and the only FDA-approved medication for the treatment of postpartum depression (PPD).
Alexander B. Horwitz   +2 more
doaj   +1 more source

Sedation-Induced Burst Suppression Predicts Positive Outcome Following Traumatic Brain Injury

open access: yesFrontiers in Neurology, 2021
While electroencephalogram (EEG) burst-suppression is often induced therapeutically using sedatives in the intensive care unit (ICU), there is hitherto no evidence with respect to its association to outcome in moderate-to-severe neurological patients. We
Joel Frohlich   +11 more
doaj   +1 more source

Doctor or drug dealer? International legal provisions for the legitimate handling of drugs of abuse [PDF]

open access: yes, 2020
© The Author(s) 2020. The final, definitive version of this paper has been published in: Gallagher, C. T., Atik, S. K., Isse, L., & Mann, S. K. (2020). Doctor or drug dealer?
Atik, Sanaa   +3 more
core   +2 more sources

New Methodology for the Synthesis of Thiobarbiturates Mediated by Manganese(III) Acetate

open access: yesMolecules, 2012
A three step synthesis of various thiobarbiturate derivatives 17–24 was established. The first step is mediated by Mn(OAc)3, in order to generate a carbon-carbon bond between a terminal alkene and malonate.
Patrice Vanelle   +2 more
doaj   +1 more source

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