Results 21 to 30 of about 24,812 (221)

Hyperalgesic effect induced by barbiturates, midazolam and ethanol: pharmacological evidence for GABA-A receptor involvement

Brazilian Journal of Medical and Biological Research, 1997
The involvement of GABA-A receptors in the control of nociception was studied using the tail-flick test in rats. Non-hypnotic doses of the barbiturates phenobarbital (5-50 mg/kg), pentobarbital (17-33 mg/kg), and thiopental (7.5-30 mg/kg), of the ...
M.A.K.F. Tatsuo, C.M. Yokoro, J.V. Salgado, S.M.S. Pesquero, M.A.P. Santana, J.N. Francischi   +5 more
doaj   +1 more source

Rectal Thiopental versus Intramuscular Ketamine in Pediatric Procedural Sedation and Analgesia; a Randomized Clinical Trial

Archives of Academic Emergency Medicine, 2018
Introduction: Physicians frequently deal with procedures which require sedation of pediatric patients. Laceration repair is one of them. No study has been performed regarding the comparison between induction of sedation with sodium thiopental and ...
Reza Azizkhani, Mehrdad Esmailian, Azadeh shojaei, Keihan Golshani   +3 more
doaj   +1 more source

The Hydrogen Bonded Structures of Two 5-Bromobarbituric Acids and Analysis of Unequal C5–X and C5–X′ Bond Lengths (X = X′ = F, Cl, Br or Me) in 5,5-Disubstituted Barbituric Acids

Crystals, 2016
The crystal structure of the methanol hemisolvate of 5,5-dibromobarbituric acid (1MH) displays an H-bonded layer structure which is based on N–H∙∙∙O=C, N–H∙∙∙O(MeOH) and (MeOH)O–H∙∙∙O interactions.
Thomas Gelbrich, Doris E. Braun, Stefan Oberparleiter, Herwig Schottenberger, Ulrich J. Griesser   +4 more
doaj   +1 more source

Determination of Barbiturates in Biological Specimens by Flat Membrane-Based Liquid-Phase Microextraction and Liquid Chromatography-Mass Spectrometry

Molecules, 2019
The wide abuse of barbiturates has aroused extensive public concern. Therefore, the determination of such drugs is becoming essential in therapeutic drug monitoring and forensic science.
Ruiqin Zhu, Ying Dong, Xiangyang Cai, Chuixiu Huang   +3 more
doaj   +1 more source

Associations of Adverse Clinical Course and Ingested Substances among Patients with Deliberate Drug Poisoning: A Cohort Study from an Intensive Care Unit in Japan. [PDF]

PLoS ONE, 2016
Some patients with deliberate drug poisoning subsequently have an adverse clinical course. The present study aimed to examine whether the type of drugs ingested and psychiatric diagnoses were related to an adverse clinical course.We conducted a cohort ...
Kanako Ichikura, Yasuyuki Okumura, Takashi Takeuchi   +2 more
doaj   +1 more source

Chemical structures of selected barbiturates.

, 2012
Chemical structures of selected barbiturates.
L. Sangeetha Vedula (184331), Qing Cheng Meng (184336), Weiming Bu (184333), Renyu Liu (184348), Jin Xi (184341), Patrick J. Loll (184358), Simon Oakley (132793), Roderic G. Eckenhoff (160628)   +7 more
core   +1 more source

Larvicidal and Nematicidal Activities of 3-Acylbarbituric Acid Analogues against Asian Tiger Mosquito, Aedes albopictus, and Pine Wood Nematode, Bursaphelenchus xylophilus

Molecules, 2017
Widespread concern for the occurrence of resistant strains, along with the avoidance of the use of highly toxic insecticides and their wide environmental dispersal, highlights the need for the development of new and safer pest control agents.
Seon-Mi Seo, Hyo-Rim Lee, Ji-Eun Lee, Yong-Chul Jeong, Hyung-Wook Kwon, Joon-Kwan Moon, Mark G. Moloney, Il-Kwon Park   +7 more
doaj   +1 more source

Case report: Fatal poisoning caused by additive effects of two barbiturates

Frontiers in Pharmacology, 2023
A case of fatal poisoning involving multiple psychotropic drugs is presented. Quantitative toxicological analysis showed femoral blood concentrations of pentobarbital, phenobarbital, duloxetine, acetaminophen and tramadol were 10.39, 22.57, 0.22, 0.61 ...
Sella Takei, Hiroshi Kinoshita, Mostofa Jamal, Mitsuru Kumihashi, Tadayoshi Yamashita, Etsuko Tanaka, Sachiko Kawahara, Hiroko Abe, Kunihiko Tsutsui, Shoji Kimura   +9 more
doaj   +1 more source

Animal stroke models and outcome evaluation: A review

Animal Models and Experimental Medicine, EarlyView.
Rodents are the preeminent stroke model species. Large animal models exist too, but are poorly standardized. Ischemic and hemorrhagic experimental models are available, with the intraluminal filament model being predominant. Outcomes are evaluated via quantifying subjects' sensorimotor impairment, cognitive memory faculties, degree of cellular ...
Solsa Cariba, Helen M. Atkinson, Anthony K. C. Chan   +2 more
wiley   +1 more source

Analysis of Barbiturates by GC/MS, HPLC and Chemical Ionization [PDF]

, 2012
Barbiturates are derivatives of barbituric acid. They act as central nervous depressants. These drugs are frequently used as sedatives or anesthetics. It is a simple and reproducible method for the analysis of barbiturates.
Ravipati, Deepthi
core   +1 more source