Results 31 to 40 of about 6,005 (131)

Meningococcal Serogroup Y Meningitis Reveals Inborn Factor B Deficiency

European Journal of Immunology, Volume 56, Issue 2, February 2026.
We report a novel case of complete complement Factor B deficiency revealed by invasive meningococcal disease. Using combined functional and genetic analyses, we demonstrate that loss of Factor B abolishes alternative pathway activity despite detectable protein levels. These findings provide a mechanistic framework relevant to complement diagnostics and
Camille Bougeard, Eléonore Eskander, Paula Vieira Martins, Joan Bitan, Julia Roquigny, Christèle Kyheng, Tamazoust Guiddir, Véronique Frémeaux‐Bacchi, Cécile Gonnin, Carine ElSissy   +9 more
wiley   +1 more source

Exploring the active components and mechanism of Ziziphi Spinosae Semen in treating insomnia by network pharmacology and metabonomics

Journal of Future Foods
Insomnia, a sleep-disordered disease, is characterized by difficulty in falling asleep, decrease of sleep quality and sleep time, decline of memory and attention. Ziziphi Spinosae Semen (ZSS) is one of the important “medicine-food” herbs for insomnia and
Xia Yu, Ziheng Jin, Linzheng Li, Jinmei Wang, Changyang Ma, Xuqiang Liu   +5 more
doaj   +1 more source

Morphine Tolerance Gated through EZH2‐Mediated Suppression of Trpc5 in Spinal GABAergic Interneurons in Male Mice

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan, Mengyao Zhang, Haiyue Guo, Yan Xu, Chenjie Xu, Fan Hu, Yinbing Pan, Xian Wang, Wentao Liu, Chun‐Yi Jiang   +9 more
wiley   +1 more source

MUC4 mutations promote a thrombotic phenotype in patients with paroxysmal nocturnal haemoglobinuria by increasing the deposition of terminal complement

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
1. PNH patients lack the complement regulatory proteins CD55 and CD59, triggering excessive activation of the terminal complement pathway and a prothrombotic state. 2. MUC4 mutation is an independent thrombotic risk factor in PNH. 3. Mutation/down‐regulation of MUC4 promotes the abnormal deposition of excessively activated terminal complement ...
Yingying Chen, Mengting Che, Chaomeng Wang, Qiaoyi Bronte Zhang, Weixin Chen, Hui Liu, Chunyan Liu, Guang Sheng Ling, Rong Fu   +8 more
wiley   +1 more source

Micropogonias furnieri (Desmarest, 1823): estudo quali-quantitativo da variação ontogenética do padrão eletroforético de proteínas gerais do cristalino Micropogonias furnieri (Desmarest, 1823) quali-quantitative studies on ontogenetic variation of the electrophoretic patterns of eye-lens proteins

Brazilian Journal of Oceanography, 1985
Foram analisadas as possíveis variações do padrão eletroforético de proteínas gerais do cristalino de Micropogonias furnieri (Desmarest, 1823), em função do desenvolvimento ontogenetico, do sexo e do ciclo de maturaçao das gonadas, com vistas a sua ...
Anna Emília Amato de Moraes Vazzoler, Van Ngan Phan, Whilar Malgor Thomas Demasi, Hana Suzuki, Vicente Gomes   +4 more
doaj   +1 more source

Passage of Barbital into Cerebrospinal Fluid.

Experimental Biology and Medicine, 1960
SummaryExperiments in dogs have shown that barbital passes slowly into the brain and even more slowly into cerebrospinal fluid. It is possible that the blood cerebrospinal fluid barrier and blood brain barrier are similar for this drug.
L C, MARK, L, BRAND, P G, DAYTON, D, TALLER, E M, PAPPER   +4 more
openaire   +2 more sources

Exploring the Potential Mechanism of Umbilical Cord Mesenchymal Stem Cell Therapy for Chronic Atrophic Gastritis Based on Multi‐Omics Technology

Stem Cells International, Volume 2026, Issue 1, 2026.
Background Chronic atrophic gastritis (CAG), a prevalent gastrointestinal disorder, is characterized by gastric mucosal atrophy and increased cancer risk. Mesenchymal stem cells (MSCs) exhibit immunomodulatory, anti‐inflammatory, and tissue‐regenerative properties; however, their therapeutic potential for CAG remains underexplored.
Pengchao Bai, Qichao Liu, Miaomiao Yin, Yan Liu, Jianliang Sui, Saihan Wang, Ruikang Jia, Huiyun Liu, Feiyue Zhao, Alain Chapel   +9 more
wiley   +1 more source

Sociedad de Estudios de Patología Quirúrgica: Estudio experimental de un nuevo anestésico general. para uso en los animales de laboratorio

Revista de la Facultad de Medicina, 1933
El Amytal, producto norteamericano de síntesis, es un derivado del Barbital, o ácido dietilbarbitúrico, del cual proviene por sustitución en su fórmula química, de uno de los grupos Etil por uno Iso-amil.
Efraim Silva Rebolledo, Alfonso Meisel
doaj  

Photopharmacology beyond azobenzene photoswitches

Responsive Materials, Volume 3, Issue 4, November 2025.
Photopharmacology is advancing beyond traditional azobenzene photoswitches by developing new photoresponsive molecules with improved thermal stability, efficiency, and long‐wavelength activation, enhancing their potential for precise biomedical applications.
Huichao Guo, Jinghong Dai, Long Deng, Zhiwei Zhang, He Tian, Junji Zhang   +5 more
wiley   +1 more source

Age‐Related Involutory Changes in Bursa of Fabricius of Anas crecca: Histomorphometric and Ultrastructural Investigation

Veterinary Medicine and Science, Volume 11, Issue 5, September 2025.
This scientific diagram illustrates age‐related changes in the Bursa of Fabricius (BF) of green‐winged teal (Anas crecca) ducks at two developmental stages. In the 8th week, the BF shows maximum maturation with peak morphometric measurements (body weight, bursal dimensions), the thickness of cortex and medulla layers and well‐developed ultrastructure ...
Zeinab Abdel‐Fattah, Ahlam Mostafa El‐Bakry, Abdelaziz S. A. Abuelsaad, Ayman M. Abdel‐Aziz, Ezzat M. Awad, Hossam Ebaid, Rasha E. H. Abo‐Eleneen   +6 more
wiley   +1 more source