Results 41 to 50 of about 6,005 (131)

Safety, Efficacy, and Patient‐Reported Outcomes From a Phase 2 Randomized Trial of Pozelimab and Cemdisiran Combination in Patients With Paroxysmal Nocturnal Hemoglobinuria

eJHaem, Volume 6, Issue 4, August 2025.
ABSTRACT Introduction Paroxysmal nocturnal hemoglobinuria (PNH) is an ultra‐rare, life‐threatening disease associated with chronic intravascular hemolysis due to uncontrolled complement activation. PNH results in anemia with an increased risk of thrombosis, and often causes severe fatigue, and decreased physical function and health‐related quality of ...
Jun‐Ho Jang, Raymond Siu Ming Wong, Christopher Hartford, Rodrigo Pavani, Lisa Aurand, Quang Nguyen, Kosalai Mohan, Karoline Meagher, Steven Sherman, Diana Rofail, Lorah Perlee, Amal Souttou, Richard J. Kelly   +12 more
wiley   +1 more source

A short‐term dietary administration of 1,8‐cineole and lactic acid alleviates transportation stress in common carp, Cyprinus carpio

Journal of the World Aquaculture Society, Volume 56, Issue 4, August 2025.
Abstract Fish transportation is stressful, causing metabolic stress, oxidative stress, and immunosuppression. Dietary additives can boost fish antioxidant and immune responses; hence, using functional feeds can alleviate the negative effects of transportation in fish. In the present study, common carp (33.2 ± 1.72 g) were fed diets containing 5 g/kg of
Morteza Yousefi, Seyyed Morteza Hoseini, Seyed Hossein Hoseinifar, Hossein Adineh, Ali Taheri Mirghaed   +4 more
wiley   +1 more source

Drug‐Event Pairs as Indicators for the Detection of Adverse Drug Reactions during Hospitalization in Routinely Collected Electronic Data Sources

Clinical Pharmacology &Therapeutics, Volume 117, Issue 6, Page 1811-1819, June 2025.
Adverse drug reactions (ADRs) are a common cause of morbidity and mortality in hospitalized patients. Identification of ADRs in clinical practice, surveillance and research is essential to prevent further harm. The aim of this study was to assess the likelihood of drugs contributing to clinically important inpatient adverse events, in order to provide ...
Anna Maria Wermund, Annette Haerdtlein, Wolfgang Fehrmann, Clara Weglage, Tobias Dreischulte, Ulrich Jaehde   +5 more
wiley   +1 more source

Vesiculation as potential novel pathogenic mechanism in autoimmune hemolytic anemia

Transfusion, Volume 65, Issue 6, Page 1132-1144, June 2025.
Abstract Background Autoimmune hemolytic anemia (AIHA) is typically mediated by immunoglobulin G (IgG) or immunoglobulin M (IgM) antibodies, and more rarely by immunoglobulin A (IgA). The mechanism of red blood cell (RBC) destruction in IgA‐mediated AIHA is not well understood.
Esther C. W. de Boer, Femke V. M. Mulder, Silvia Neri, Marije Wiskerke ‐ van Stuijvenberg, Janine J. G. Arts, Simon Tol, Boukje Beuger, Matthieu C. J. Bosman, Noortje Thielen, René van der Griend, Claudia C. Folman, Masja de Haas, Robin van Bruggen, Richard B. Pouw, Josephine M. I. Vos   +14 more
wiley   +1 more source

Proteolysis‐Based Biomarker Repertoire of the Neurofilament Proteome

Journal of Neurochemistry, Volume 169, Issue 3, March 2025.
Protein degradation underlies essential biological processes, and its dysfunction can contribute to disease. By systematically charting the neurofilament degradome, this study offers a conceptual framework and methodological blueprint for mapping a complete protein degradome atlas.
Axel Petzold
wiley   +1 more source

Effect of anesthesia and measurement site on baseline blood pressure in rats (2021–2024)

Open Veterinary Journal
Rats are frequently used in laboratory experiments and are suitable animal models for physiology, pharmacology, pathophysiology, or behavioral studies. Since rats are also used in experimental surgery, adequate anesthesia and analgesia must be ensured to
Pavol Švorc, Soňa Grešova, Viktória Novotna   +2 more
doaj   +1 more source

Proximity Effects and Aggregation of Hamilton‐Receptor Barbiturate Host–Guest Complexes Probed by Cross‐Metathesis and ESI MS Analysis

Chemistry – A European Journal, Volume 31, Issue 8, February 6, 2025.
The formation of Hamilton receptor‐barbiturate host–guest complexes (H−B) and their aggregates was studied using a two‐step method, firstly covalent fixation via cross‐metathesis (CM), followed by ESI MS analysis. This approach, using a cyclopentene‐modified Hamilton receptor (H) and allyl‐substituted barbital (B), confirmed the formation of hydrogen ...
Chenming Li, Pascal Mai, Niclas Festag, Anja Marinow, Wolfgang H. Binder   +4 more
wiley   +1 more source

Effect of Sleep-improvement and Mechanism of Yanwo Ejiao Compound in Mice

Shipin gongye ke-ji
Objective: To evaluate improvement of sleep function and mechanism of Yanwo Ejiao compound in mice. Methods: Balb-c mice were randomly assigned to five groups: A blank control group, a positive drug group, and three Yanwo Ejiao compound groups receiving ...
Haiyun ZHENG, Zhigang WANG, Shaonan WANG, Bin WANG   +3 more
doaj   +1 more source

Separación de proteínas sarcoplásmicas por electroforesis en gel de agarosa como método para la identificación de algunas especies de pescado

Revista Científica, 2010
Para la identificación de las especies de pescado se han desarrollado métodos bioquímicos que van desde la determinación de isoenzimas hasta las técnicas de reacción en cadena de polimerasa (PCR) y electroforesis de ácidos nucleicos.
Gabriel Torres Ferrari, Pedro Izquierdo Corser, Enrique Márquez Salas, Yasmina Barboza   +3 more
doaj  

Molecularly Imprinted Polymer Modified with an MWCNT Nanocomposite for the Fabrication of a Barbital Solid-Contact Ion-Selective Electrode. [PDF]

ACS Omega, 2022
Al Shagri LMS, Kamel AH, Abd-Rabboh HSM, Bajaber MA.   +3 more
europepmc   +1 more source